New treatment strategies for vascular endothelial damage due to stress-induced insulin resistance
| Project/Area Number |
20591835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUGITA Michiko 熊本大学, 医学部附属病院, 講師 (70305019)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | インスリン抵抗性 / 血管内皮障害 / 糖尿病 |
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| Research Abstract |
RAS inhibitors(farnesyltransferase inhibitor) on stress-induced insulin resistance and vascular endothelial damage were evaluated for therapeutic potential. Vascular endothelial damage is a major cause of organ failure in critical stress-induced insulin resistance. Meanwhile HMG-CoA reductase inhibitor(statin) lipid-lowering-independent effect is the suppression of protein farnesylation. If you can inhibit the vascular endothelial damage in the security inhibitor of farnesyltrans and more will be expected to spread to statin therapy in vascular endothelial damage. LPS mice as a model for critical disease. C57BL6 mice intraperitoneally administered LPS30mg/kg, FTI RAS inhibitor was administered intraperitoneally and then 18 hours after administration of LPS, experiments were subjected to the ascending aorta were taken down. Observation was continued for six days after the procedure. FTI277 administration has significantly improved the survival rate. Farnesyltransferase inhibitor suppresses oxidative stress in endothelial cells, is suggested to improve survival by maintaining organ blood flow can be expected as a potential therapeutic agent.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice Metabolism2012
Author(s)
Sugita M, Sugita H, Kim M, Mao J, Yasuda Y, Habiro M, Shinozaki S, Yasuhara S, Shimizu N, Martyn JA, Kaneki M.
Volume
61(1)(in press)
Pages
127-36
Related Report
Peer Reviewed
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