Development of new therapeutic strategies for severe sepsis by blood purification therapy targeting at elimination of HMGB1.

• Project/Area Number: 20591836
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Oita University
• Principal Investigator: HIDAKA Seigo Oita University, 医学部, 助教 (00404385)
• Co-Investigator(Kenkyū-buntansha): IWASAKA Hideo 大分大学, 医学部, 准教授 (90175216)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 感染症 / 敗血症

Research Abstract

Severe sepsis can result in multiple organ dysfunction syndrome (MODS), a potentially life-threatening condition. In the process, high mobility group box 1 protein (HMGB1) was found to be a key mediator of exacerbating organ injury. Although sepsis is the common cause of mortality in intensive care units, few therapies have established sufficient evidence. In the present study, we evaluated the effects of blood purification therapy targeting at elimination of HMGB1 in a LPS-induced systemic inflammatory rat model. As a result, we showed that blood purification therapy (hemodiafiltration, leukocytapheresis) reduced serum HMGB1 levels and prevented organ injury, and increased survival in our model.

Research Products

• [Journal Article] Continuous Hemodiafiltration Therapy Ameliorates LPS-Induced Systemic Inflammation in a Rat Model. (2010)
  • Author(s): Satoshi Hagiwara, Hideo Iwasaka, Akira Hasegawa, Seigo Hidaka, Aya Uno, Ueo Kaori, Tomohisa Uchida, Takayuki Noguchi.
  • Journal Title: J Surg Res. 29
  • Peer Reviewed
• [Journal Article] Filtration leukocytapheresis therapy ameliorates LPS-induced systemic inflammation in a rat model. (2010)
  • Author(s): Satoshi Hagiwara, Hideo Iwasaka, Akira Hasegawa, Seigo Hidaka, Aya Uno, Kaori Ueo, Tomohisa Uchida, Takayuki Noguchi.
  • Journal Title: J Surg Res. 8
  • Peer Reviewed
• [Journal Article] Continuous hemodiafiltration therapy ameliorates LPS-induced systemic inflammation in a rat model. (2010)
  • Author(s): 萩原聡
  • Journal Title: J Surg Res Volume: 29
  • Peer Reviewed
• [Journal Article] Filtration leukocytapheresis therapy ameliorates LPS-induced systemic inflammation in a rat model. (2010)
  • Author(s): 萩原聡
  • Journal Title: J Surg Res Volume: 8
  • Peer Reviewed