Study for interaction between D-serine synthesis and development of morphine tolerance
| Project/Area Number |
20591843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokai University |
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Principal Investigator |
ITO Kenji Tokai University, 医学部, 講師 (10317779)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 疼痛管理学 / モルヒネ / 麻薬 / ケタミン / Dセリン / セリンラセマーゼ / Dアミノ酸酸化酵素 / 鎮痛 / 耐性 / in situ hybridization / 免疫組織化学 / NMDA受容体 |
|---|
| Research Abstract |
Repeated administration of morphine for 30 days produced a significant augmentations of both the mRNA and protein expressions of serine racemase in all the brain regions, and caused a slight but significant elevation in the elevated D-seirne revel in the cortex, striatum and hippocampus. The antinociception induced by the intracerebroventricular (i.c.v.) administration of D-serine was attenuated by i.c.v. administration of midazolam. These results indicate the elevated D-serine level following the chronic morphine treatment could at least in part be involved in the activation of NMDA receptors via the glycine site.
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Report
(4 results)
Research Products
(23 results)
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[Presentation]2008
Author(s)
吉川正信,四宮敬史,小林智美,赤堀一仁,橋本篤司,小林広幸,川口充
Organizer
第81回日本薬理学会年会
Year and Date
2008-03-17
Related Report
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