| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Research Abstract |
Remodeling of pulmonary vasculature (neointimal formation) is a key pathophysiology of development of pulmonary hypertension. The primary purpose of this research is to establish severe form of pulmonary hypertension model in mice. We observed that three-week-long exposure to hypoxic (FiO2=17%) environment with monocrotaline injection caused severe pulmonary hypertension. Unfortunately, more than 50% of these pulmonary hypertensive mice were too sick to tolerate an experiment of measurement of pulmonary artery pressure, necessitating abandon of this experimental model. Using a large cohort of pregnant women with congenital heart disease, we revealed the presence of pulmonary hypertension is a risk factor for maternal and neonatal poor outcome of pregnancy.
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