| Project/Area Number |
20591850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
MATSUI Hiroshi Gunma University, 大学院・医学系研究科, 助教 (40450374)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kazuhiro 群馬大学, 大学院・医学系研究科, 教授 (80312891)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 前立腺癌 / 家族歴 / 遺伝子多型 / 一塩基多型 / マイクロサテライト |
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| Research Abstract |
This study included probands from 134 familis with familial prostate cancer, 158 with sporadic prostate cancer and 120 with benign prostatic hyperplasia as the control subjects. The SNP marker rs1447295 was genotyped by real-time PCR using Taq-Man^[○!R] SNP genotyping assay. And the microsatellite marker DG8S737 was genotyped using a PCR based assay. There was a significant positive association between the DG8S737-12 allele and familial prostate cancer risk (OR 1.86, 95% CI 1.11-3.00, p=0.02) and a significant association of risk with the rs1447295 A allele (OR 2.36, 95% CI 1.41-3.94, p=0.002). Significant associations were noted for each marker in men with a high Gleason score. Two alleles at 8q24 are genetic risk factors for familial prostate cancer and high grade disease in Japanese population.
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