| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Increased serum cholesterol concentration due to westernized diet may affect mineral corticoids concentration and following changes in sex hormone environment in human. In the present study, we investigated correlation between serum sex hormones and promotion of prostate cancer. A case control study demonstrated that patients diagnosed with prostate cancer had significantly higher serum pregnenolone (P5) level and lower both estradiol and 11-deoxycorticosterone levels in the serum taken several years ago compared with men without clinically manifested prostate cancer. An acceleration of converting enzyme, CYP11A1, may play some role to lead such a specific endocrine feature and following cancer development.
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