| Project/Area Number |
20591854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OZONO Seiichiro Hamamatsu University School of Medicine, 医学部, 教授 (00183228)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYAMA Tatsuya 浜松医科大学, 医学部附属病院, 講師 (90324350)
TERATANI Takumi 自治医科大学, 医学部, 助教 (70373404)
TAKAOKA Naohisa 浜松医科大学, 医学部, 特任研究員 (30467229)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 腫瘍学 / 腎癌 / 脳型遊離脂肪酸結合蛋白 / S100蛋白 / 低酸素バイオロジー / バイオマーカー |
|---|
| Research Abstract |
We identified brain-type fatty acid binding protein(B-FABP) as a specific biomarker. First of all, we have made up anti-B-FABP antibody, we also determined the expression of B-FABP in the urine. Promoter analysis revealed that Brn-2, NF1 and YY1 affect on the expression of B-FABP. Function determination of B-FABP by metabolome analysis in tumor microenvironment should be lead to the development of tumor biology.
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