| Project/Area Number |
20591855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIMURA Kouji Kyoto University, 医学研究科, 講師 (40397542)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Osamu 京都大学, 医学研究科, 教授 (90260611)
NAKAMURA Eijirou 京都大学, 医学研究科, 講師 (90293878)
KANEMATSU Akihiro 京都大学, 医学研究科, 助教 (90437202)
|
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| Co-Investigator(Renkei-kenkyūsha) |
MINATO Nagahiro 京都大学, 生命科学研究科, 教授 (40137716)
HATTORI Masakazu 京都大学, 生命科学研究科, 准教授 (40211479)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 前立腺癌 / Rap1 / Spa-1 / 転移 / 癌転移 / small G protein / SPA-1 / RAP1 / ECM |
|---|
| Research Abstract |
The expression of SPA-1, one of the Rap1GAPs, was increased in metastatic tissues of human prostate cancer, compared with the primary sites. Based on the results, we found that SPA-1 protein promotes the invasion and metastasis of prostate cancer, by down-regulation of attachment to ECM through Rap1's inactivation and by suppressing transcription of ECM-asscociated genes through translocation of Brd4.
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