The molecular mechanism of Actinin-4 in proliferation, invasion and metastasis of cancer
| Project/Area Number |
20591857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKATSUJI Hiroyoshi The University of Tokushima, 病院, 助教 (50437638)
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA HiroーOmi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10214446)
TAKAHASHI Masayuki 徳島大学, 病院, 講師 (50325255)
FUKUMORI Tomoharu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10314874)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Actinin4 / 泌尿器癌 / 浸潤 / 転移 / 接着 |
|---|
| Research Abstract |
Actinin-4 mRNA and protein levels are elevated in bladder cancer cells lines that exhibit increased growth and invasion activity. In addition, actinin-4 knockdown inhibited invasion of bladder cancer cells, but did not alter their growth. In conclusion, we hypothesize that the accumulation of actinin-4 in the cell cytoplasm, rather than its recruitment to the cell membrane, is related to an increased susceptibility of tumor invasion and metastasis.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Late Rescurrence of Renal Cell Carcunoma : Retrospective and Collaborative Study of the Japanese Society of Renal Cancer2011
Author(s)
Miyao N, Naito S, Ozono S, Shinohara N, Masumori N, Igarashi T, Nakao M, Tsushima T, Senga Y, Horie S, Kanayama H, Tokuda N, Kobayashi M
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Journal Title
Oncology 77
Pages: 3779-3874
Related Report
Peer Reviewed
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[Journal Article] Late Recurrence of Renal Carcinoma : Retrospective and Collaborative Study of the Japanese Society of Renal Cancer2011
Author(s)
Miyao N, Naito S, Ozono S, Shinohara N, Masumori N, Igarashi T, Nakao M, Tsushima T, Senga Y, Horie S, Kanayama HO, Tokuda N, Kobayashi M
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Journal Title
UROLOGY 77・2
Pages: 379-384
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of serum hepatocyte growth factor in clear cell renal cell carcinoma : comparison with serum vascular endothelial growth factor2008
Author(s)
Tanimoto S, Fukumori T, Gad El-Moula, Shiirevnyamba A, Kinouchi S, Koizumi T, Nakanishi R, Yamamoto Y, Taue R, Yamaguchi K, Nakatsuji H, Kishimoto T, Izaki H, Oka N. Takahashi M, Kanayama H
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Journal Title
The Journal of Medical Investigation 55
Pages: 106-111
NAID
Related Report
Peer Reviewed
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[Journal Article] Effect of aldosterone on isolated human penile corpus cavernosum tissue2008
Author(s)
Muguruma H, Kawanishi Y, Sugiyama H, Kagawa J, Tanimoto S, Yamanaka M, Kojima K, Anzai H, Numata A, Kishimoto T, Kanayama H
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Journal Title
BJU International 102
Pages: 500-503
Related Report
Peer Reviewed
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