Development of anti-TRAIL receptor antibod y in combination with chemotherapeutic therapy against advanced genitourinary cancers : expansion of animal model
| Project/Area Number |
20591858
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
WU Xiu-Xian Kagawa University, 医学部, 助教 (10346645)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUNEMORI Hiroyuki 香川大学, 医学部附属病院, 助教 (20380173)
SUGIMOTO Mikio 香川大学, 医学部附属病院, 准教授 (10243768)
INUI MASASHI 香川大学, 医学部附属病院, 講師 (40314918)
KAKEHI Yoshiyuki 香川大学, 医学部, 教授 (20214273)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | TRAIL-R2 / laxatumumab / アドリアマイシン / 腎癌細胞 / カスパーゼ / アポトーシス / lexatumumab / Laxatumumab |
|---|
| Research Abstract |
Development of anti-TRAIL receptor antibody in combination with chemotherapeutic therapy against advanced genitourinary cancers was performed. We found : (1) anti-TRAIL death receptor 2 antibody lexatumumab in combination with clinically achievable concentrations of adriamycin, cisplastin, epirubicin, or pirarubicin had a synergistic cytotoxic effect ; (2) the synergistic cytotoxicity was significantly inhibited by caspase inhibitors demonstrating caspase cascade, especially caspase-8 plays an important role in the synergy ; (3)PCR array analysis identified 26 genes related with apoptosis.
|
Report
(4 results)
Research Products
(42 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer.2009
Author(s)
Li Y, Li X, Dai H, Sun X, Li J, Yang F, Gu H, Yong Y, Jin Z, Chu Y, Jin X, Kakehi Y, Wu X-X
-
Journal Title
BJU International 103
Pages: 547-552
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Expression of Lysophospholipase D (Autotaxin) and Acylglycerol kinase enzymes in Prostate Cancer cells with relevance to Clinicopathological parameters American Urological2009
Author(s)
Nouh MA, Wu X-X, Okazoe H, Tsunemori H, Abou-Zeid AM, Saleem MD, Inui M, Sugimoto M, Junken Aoki, Kakehi Y
Organizer
Association 2009 Annual Meeting.
Place of Presentation
Chicago, USA
Related Report
-
-
