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Development of anti-TRAIL receptor antibod y in combination with chemotherapeutic therapy against advanced genitourinary cancers : expansion of animal model

Research Project

Project/Area Number 20591858
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKagawa University

Principal Investigator

WU Xiu-Xian  Kagawa University, 医学部, 助教 (10346645)

Co-Investigator(Kenkyū-buntansha) TSUNEMORI Hiroyuki  香川大学, 医学部附属病院, 助教 (20380173)
SUGIMOTO Mikio  香川大学, 医学部附属病院, 准教授 (10243768)
INUI MASASHI  香川大学, 医学部附属病院, 講師 (40314918)
KAKEHI Yoshiyuki  香川大学, 医学部, 教授 (20214273)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsTRAIL-R2 / laxatumumab / アドリアマイシン / 腎癌細胞 / カスパーゼ / アポトーシス / lexatumumab / Laxatumumab
Research Abstract

Development of anti-TRAIL receptor antibody in combination with chemotherapeutic therapy against advanced genitourinary cancers was performed. We found : (1) anti-TRAIL death receptor 2 antibody lexatumumab in combination with clinically achievable concentrations of adriamycin, cisplastin, epirubicin, or pirarubicin had a synergistic cytotoxic effect ; (2) the synergistic cytotoxicity was significantly inhibited by caspase inhibitors demonstrating caspase cascade, especially caspase-8 plays an important role in the synergy ; (3)PCR array analysis identified 26 genes related with apoptosis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009 2008 Other

All Journal Article (25 results) (of which Peer Reviewed: 20 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Effect of a phytotherapeutic agent, Eviprostat^<【○!R】>R, on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis.2011

    • Author(s)
      Sugimoto M, Oka M, Tsunemori H, Yamashita M, Kakehi Y
    • Journal Title

      Prostate 71

      Pages: 438-444

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] View and present status of personnel involved in clinical trials : a survey of participants from the First Symposium of the Shikoku Collaborative Group for Promotion of Clinical Trials.2011

    • Author(s)
      Yanagawa H, Irahara M, Houchi H, Kakehi Y, Moritoyo T, Nomoto M, Miyamura M, Shuin T.
    • Journal Title

      J Med Invest 58

      Pages: 81-85

    • NAID

      130004465249

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a phytotherapeutic agent, Eviprostat[○!R], on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis.2011

    • Author(s)
      Sugimoto M, et al.
    • Journal Title

      Prostate

      Volume: 71 Pages: 438-444

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bladder Cancer Working Group report.2011

    • Author(s)
      Kakehi Y, et al.
    • Journal Title

      Jim J Clin Oncol

      Volume: 40 Pages: 157-164

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bladder Cancer Working Group report.2010

    • Author(s)
      Kakehi Y, Hirao Y, Kim WJ, Ozono S, Masumori N, Miyanaga N, Nasu Y, Yokomizo A.
    • Journal Title

      Jpn J Clin Oncol 40

      Pages: 157-164

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography with 18F-fluorodeoxyglucose is a useful tool for the diagnosis of pheochromocytomas without distant metastasis, where malignancy is suspected on the basis of histopathologic analysis.2010

    • Author(s)
      Kikuchi F, Imachi H, Murao K, Ohyama T, Miyai Y, Kushida Y, Haba R, Kakehi Y, Ishida T.
    • Journal Title

      Am J Med Sci 340

      Pages: 160-163

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 転移性腎細胞癌に対する薬物療法の新たな展開2010

    • Author(s)
      筧善行
    • Journal Title

      臨床腫瘍プラクティス 6

      Pages: 342-352

    • Related Report
      2010 Final Research Report
  • [Journal Article] II.膀胱癌基礎研究総論膀胱癌基礎研究の歴史と現状-将来展望も含めて-.腎・泌尿器癌-基礎・臨床研究のアップデート-2010

    • Author(s)
      筧善行, 呉秀賢
    • Journal Title

      日本臨床 68

      Pages: 197-202

    • Related Report
      2010 Final Research Report
  • [Journal Article] Positron emission tomography with 18F-fluorodeoxyglucose is a useful tool for the diagnosis of pheochromocytomas without distant metastasis, where malignancy is suspected on the basis of histopathologic analysis.2010

    • Author(s)
      Kikuchi F, Kakehi Y, et al.
    • Journal Title

      Am J Med Sci

      Volume: 340 Pages: 160-163

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Apoptosis in Human Renal Cell Carcinoma Cells by Vitamin E Succinate in A Caspase-Independent Manner.2009

    • Author(s)
      Wu X-X, Kakehi Y, Jin X-H, Inui M, Sugimoto M.
    • Journal Title

      Urology 73

      Pages: 193-199

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo.2009

    • Author(s)
      Niu YC, Liu JC, Zhao XM, Wu X-X
    • Journal Title

      Oncol Rep 21

      Pages: 145-152

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer.2009

    • Author(s)
      Li Y, Li X, Dai H, Sun X, Li J, Yang F, Gu H, Yong Y, Jin Z, Chu Y, Jin X, Kakehi Y, Wu X-X
    • Journal Title

      BJU International 103

      Pages: 547-552

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of verapamil on the expression of EGFR and nm23 in lung cancer cells.2009

    • Author(s)
      Zhang C, Lv F, Zhou L, Li X, Wu XX, Hoffman RM.
    • Journal Title

      Anticancer Research 29

      Pages: 27-32

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Lexatumumab-induced Apoptosis in Human Solid Cancer Cells by Cisplatin.2009

    • Author(s)
      呉秀賢, 筧善行
    • Journal Title

      Clin Cancer Res 15

      Pages: 2039-2047

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of lysophospholipase D (autotaxin) and acylglycerol kinase enzymes in prostate cancer with relevance to clinicopathological parameters.2009

    • Author(s)
      Nouh MA, Wu X-X, Okazoe H, Tsunemori H, Ahmed MA, Abou-Zeid AM, Inui M, Sugimoto M, Kakehi Y
    • Journal Title

      Cancer Sci 100

      Pages: 1631-1638

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 分子標的薬を用いた腎細胞がん著効例2009

    • Author(s)
      杉元幹史
    • Journal Title

      臨床腫瘍プラクティス 5

      Pages: 414-417

    • Related Report
      2010 Final Research Report
  • [Journal Article] Agonistic antibodies to tumor necrosis factor related apoptosis-inducing ligand death receptors and cancer therapy.2009

    • Author(s)
      呉秀賢, 筧善行
    • Journal Title

      中華外科雑誌 47(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【抗体を用いたがん治療の現状と問題点】腎癌(Bevacizumab)2009

    • Author(s)
      筧善行, 呉秀賢
    • Journal Title

      腫瘍内科 3

      Pages: 56-61

    • Related Report
      2010 Final Research Report
  • [Journal Article] 腎臓がんの分子標的治療-現状と問題点-2009

    • Author(s)
      筧善行
    • Journal Title

      腫瘍内科 4

      Pages: 155-161

    • Related Report
      2010 Final Research Report
  • [Journal Article] hymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer2009

    • Author(s)
      Xiuxian Wu
    • Journal Title

      BJU International 103

      Pages: 547-552

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Lexatumumab-induced Apoptosis in Human Solid Cancer Cells by Cisplatin2009

    • Author(s)
      Xiuxian Wu
    • Journal Title

      Clinical Cancer Research 15

      Pages: 2039-2047

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Apoptosis in Human Renal Cell Carcinoma Cells by Vitamin E Succinate in A Caspase-Independent Manner2009

    • Author(s)
      Xiu-Xian Wu
    • Journal Title

      Urology 73

      Pages: 193-199

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Apoptosis in Human Renal Cell Carcinoma Cells by Vitamin E Succinate in A Caspase-Independent Manner2009

    • Author(s)
      Xiu-Xian Wu, Yoshiyuki Kakehi, Xing-hua Jin, Masashi Inui, Mikio Sugimoto
    • Journal Title

      Urology 73

      Pages: 193-199

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and secretion of N-acylethanolamine-hydrolyzing acidamidase in human prostate cancer cells2008

    • Author(s)
      Jun Wang, Li-Ying Zhao, Toru Uyama, Kazuhito Tsuboi, Xiu-Xian Wu, Yoshiyuki Kakehi, Natsuo Ueda
    • Journal Title

      The Journal of Biochemistry 144

      Pages: 685-690

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile of lysophosphatidic acids-relating molecules in prostate cancer and benign prostatic hyperplasia2008

    • Author(s)
      Yu Zeng, Yoshiyuki Kakehi, Mohammed Ahmed Abmed Abdel Muneem Nouh, Hiroyuki Tsunemori, Mikio Sugimoto, Xiu-xian Wu
    • Journal Title

      Prostate 69

      Pages: 283-295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット非細菌性前立腺炎モデルにおける前立腺および尿中サイトカイン・ケモカイン濃度の解析-エビプロスタット^<【○!R】>R投与の影響-2010

    • Author(s)
      常森寛行, 杉元幹史, 末永武寛, 矢野敏史, 加藤琢磨, 平間裕美, 山下資樹, 乾政志, 筧善行
    • Organizer
      第3回排尿障害モデル動物研究会
    • Place of Presentation
      静岡市
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 早期前立腺がんに対するPSA監視療法:患者選択と経過観察方法の標準化を目指して2010

    • Author(s)
      杉元幹史, 常森寛行, 筧善行
    • Organizer
      第48回日本癌治療学会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] StageT1c前立腺癌に対するPSA監視療法 厚生省研究班(11-10)における全摘症例の検討2010

    • Author(s)
      杉元幹史, 常森寛行, 神波大己, 賀本敏行, 白石泰三, 小川修, 筧善行
    • Organizer
      第48回日本癌治療学会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Synergistic apoptosis of lexatumumab and cisplatin against human renal cell carcinoma cells in a caspase-dependent manner.2010

    • Author(s)
      Wu X-X, Kato T, Hirama H, Tsunemori H, Zhang X, Yamashita M, Inui M, Sugimoto M, Kakehi Y
    • Organizer
      4^<st> Chinese-Japanese Urological Association Meeting.
    • Place of Presentation
      Xian, China
    • Year and Date
      2010-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Synergistic apoptosis of lexatumumab and cisplatin against human renal cell carcinoma cells in a caspase-dependent manner2010

    • Author(s)
      Wu X-X, et al.
    • Organizer
      4^<th> Chinese-Japanese Urological Association Meeting
    • Place of Presentation
      Xian, China
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト固形癌細胞におけるシスプラチンによるCaspase依存症のLexatumumab誘導アポトーシスの増強2010

    • Author(s)
      呉秀賢, 常森寛行, 乾政志, 杉元幹史, 筧善行
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト固形癌細胞におけるシスプラチンによるカスパーゼ依存性のLexatumumab誘導アポトーシスの増強2010

    • Author(s)
      呉秀賢, 常森寛行, 植月祐次, 山下資樹, 平間裕美, 乾政志, 杉元幹史, 筧善行
    • Organizer
      第19回泌尿器科分子・細胞研究会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Synergistic induction of apoptosis in human solid cancer cells by Lexatumumab and cisplatin in a caspase-dependent manner.2010

    • Author(s)
      呉秀賢, 乾政志, 杉元幹史, 筧善行
    • Organizer
      The 101th Annual Meeting for AACR.
    • Place of Presentation
      Washington, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Synergistic induction of apoptosis in human solid cancer cells by Lexatumumab and cisplatin in a caspase-dependent manner2010

    • Author(s)
      Wu X-X, et al.
    • Organizer
      The 101th Annual Meeting for AACR
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎細胞癌に対する分子標的治療・現状と課題2009

    • Author(s)
      筧善行
    • Organizer
      第59回日本泌尿器科学会中部総会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of Lysophospholipase D (Autotaxin) and Acylglycerol kinase enzymes in Prostate Cancer cells with relevance to Clinicopathological parameters2009

    • Author(s)
      Mohammed Ahmed Abdel Muneem Nouh
    • Organizer
      American Urological Association 2009 Annual Meeting
    • Place of Presentation
      Chicago, IN, USA(マコーミックプレイス)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎癌の新規分子マーカーとしてのU7メッセンジャーRNA2009

    • Author(s)
      呉秀賢, アハメドハメド, 常森寛行, 乾政志, 杉元幹史, 影山進, 吉貴達寛, 筧善行
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 固形癌細胞に対する低濃度アドリアマイシンと抗DR5モノクロナル抗体Lexatumumabによるアポトーシス増強効果2009

    • Author(s)
      呉秀賢, 常森寛行, 植月祐次, 山下資樹, 上田修史, 乾政志, 杉元幹史, 筧善行
    • Organizer
      第18回泌尿器科分子・細胞研究会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2009-02-13
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Expression of Lysophospholipase D (Autotaxin) and Acylglycerol kinase enzymes in Prostate Cancer cells with relevance to Clinicopathological parameters.2009

    • Author(s)
      Nouh MA, Wu X-X, Okazoe H, Tsunemori H, Abou-Zeid AM, Saleem MD, Inui M, Sugimoto M, Aoki J, Kakehi Y
    • Organizer
      第18回泌尿器科分子・細胞研究会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2009-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of Lysophospholipase D (Autotaxin) and Acylglycerol kinase enzymes in Prostate Cancer cells with relevance to Clinicopathological parameters American Urological2009

    • Author(s)
      Nouh MA, Wu X-X, Okazoe H, Tsunemori H, Abou-Zeid AM, Saleem MD, Inui M, Sugimoto M, Junken Aoki, Kakehi Y
    • Organizer
      Association 2009 Annual Meeting.
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 固形癌細胞におけるDR4、DR5を標的とした腫瘍壊死因子関連アポトーシス誘導リガンド受容体抗体と低濃度アドリアマイシンとの併用によるアポトーシス増強2008

    • Author(s)
      呉 秀賢, アハメドマムドアプデリ ハメド, 乾 政志, 杉本 幹史, 筧 善行
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-27
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.kms.ac.jp/~uro/links.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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