• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A study of chemoprevention of prostate cancer with statins in a knock-in mouse prostate cancer model

Research Project

Project/Area Number 20591859
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagasaki University

Principal Investigator

SAKAI Hideki  Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (40235122)

Co-Investigator(Kenkyū-buntansha) IGAWA Tsukasa  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (40295069)
Research Collaborator MIYATA Yasuyoshi  長崎大学, 病院, 講師 (60380888)
MARUTA Sugure  長崎大学, 大学院
WATANABE Shin-ichi  長崎大学, 大学院
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords前立腺癌 / ノックインマウス / PSP94 / c-Fes / Fes / 経直腸的超音波断層法 / スタチン
Research Abstract

Transrectal ultrasonography with an endovascular ultrasound probe allowed longitudinal monitoring of in situ tumor growth in the genetically engineered mouse prostate cancer model, PSP-KIMAP. Although preventative effects of statins in prostate cancer were not successfully analyzed, our data suggest that a non-receptor protein-tyrosine kinase, c-Fes may be involved in the development and progression of prostate cancer via cell proliferation. We speculate that c-Fes is a possible target in the treatment and chemoprevention of prostate cancer.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal therapy2010

    • Author(s)
      Watanabe S, Miyata Y, Kanda S, Iwata T, Hayashi T, Kanetake H, Sakai H
    • Journal Title

      J Cancer Res Clin Oncol Vol.136, No.5

      Pages: 787-793

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌の化学予防2010

    • Author(s)
      酒井英樹
    • Journal Title

      癌と化学療法 37巻、1号

      Pages: 35-38

    • Related Report
      2010 Final Research Report
  • [Journal Article] E1AF expression is associated with extra-prostatic growth and matrix metalloproteinase-7 expression in prostate cancer2009

    • Author(s)
      Maruta S, Sakai H, Kanda S, Hayashi T, Kanetake H, Miyata Y
    • Journal Title

      APMIS Vol.117, No.11

      Pages: 791-796

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 前立腺癌におけるc-Fesの発現と臨床病理学的特徴や増殖、アポトーシスとの関連2010

    • Author(s)
      宮田康好
    • Organizer
      第26回前立腺シンポジウム
    • Place of Presentation
      東京コンファレンスセンター(東京都)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 前立腺癌におけるc-Fesの発現と臨床病理学的特徴や増殖、アポトーシスとの関連2010

    • Author(s)
      渡邉慎一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 前立腺癌におけるFesの臨床病理学的意義2010

    • Author(s)
      渡邉慎一
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      ホテルメトロポリタン盛岡(岩手県)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 前立腺癌発症ノックインマウスにおける血管内超音波プローブを用いた経直腸的超音波断層法の有用性2008

    • Author(s)
      丸田大
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2008-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 前立腺癌発症ノックインマウスにおける血管内超音波プローブを用いた経直腸的超音波断層法の有用性2008

    • Author(s)
      丸田 大
    • Organizer
      第9 6回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-25
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi