| Project/Area Number |
20591860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
ENOKIDA Hideki Kagoshima University, 医歯学総合研究科, 講師 (80347103)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Masayuki 鹿児島大学, 医歯学総合研究科, 教授 (90164144)
KAWAMOTO Ken 鹿児島大学, 医歯学総合研究科, 研究員 (80363620)
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| Research Collaborator |
千代丸 剛 鹿児島大学, 医歯学総合研究科, 大学院生
鑪野 秀一 鹿児島大学, 医歯学総合研究科, 大学院生
吉野 裕史 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 前立腺癌 / 尿 / メチル化 / 診断 / 腫瘍マーカー |
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| Research Abstract |
We screened methylated DNA by using oligomicroarray analyses of prostate cancer cell lines treated by a demethylating agent and focused on APC, GSTP1, and MT1G. Prostate tissues and urine samples were used for extracting their DNA, which were subjected to methylation specific PCR. The methylation status of MT1G was significantly associated with tumor stage. These markers may have potential abilities to distinguish prostate cancer from benign prostate hypertrophy.
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