| Project/Area Number |
20591861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KAWAMOTO Ken Kagoshima University, 医歯学総合研究科, 研究員 (80363620)
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| Co-Investigator(Kenkyū-buntansha) |
ENOKIDA Hideki 鹿児島大学, 医歯学総合研究科, 講師 (80347103)
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| Research Collaborator |
千代丸 剛 鹿児島大学, 医歯学総合研究科, 大学院生
鑪野 秀一 鹿児島大学, 医歯学総合研究科, 大学院生
吉野 裕史 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | マイクロRNA / 膀胱癌 / 腫瘍マーカー / 癌抑制遺伝子 |
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| Research Abstract |
We screened 157 microRNAs and identified the microRNA profile in clinical bladder cancer. We focused on the down-regulated microRNAs, such as miR-133a, and miR-145, which may have tumor suppressive function. Transfection of the target genes, such as KRT-7, FSCN1, and GST-P1, revealed that these genes might have oncogenic function. On the other hand, the expression levels of the up-regulated microRNAs, such as miR-96, miR-183, were indeed over-expressed in bladder cancer, suggesting that they might be potential biomarkers for bladder cancer.
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