The contribution of the checkpoint genes to prostate cancer hormone resistant
| Project/Area Number |
20591863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHIMOTO Yoshihiro Nagoya City University, 大学院・医学研究科, 研究員 (40244561)
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| Co-Investigator(Kenkyū-buntansha) |
TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
NAKANISHI Makoto 名古屋市立大学, 大学院・医学研究科, 教授 (40217774)
OKADA Shinsuke 名古屋市立大学, 大学院・医学研究科, 研究員 (40381818)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 前立腺癌 / ホルモン耐性 / チェックポイントキナーゼ / 細胞周期 / チェックポイント機構 / Chk1 / Nek6 / RNR |
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| Research Abstract |
The checkpoint mechanism of the cell cycle that surrounded the transcript of the androgen receptor to the hormone resistance of the prostate cancer was analyzed. Nek6 appeared in the peculiarity in the prostate tissue, and was located in 33-34 chromosome. The amount of the Nek6 appearance decreases in androgen non-dependency prostate cancer cell LNCaP-HR with about 80% of LNCaP by 50% or less of LNCaP. The amount of appearance of Chk1 has decreased in the hormone resistance prostate cancer tissues. Moreover, it was a gene that Nek6 is located in the upstream of Chk1 because Nek6 induced the appearance of Chk1 and the phosphorylation of Chk1 with in vitro, and the possibility of controlling S period by the appearance of RNR was suggested.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.2010
Author(s)
Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M
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Journal Title
Genes Dev. 24
Pages: 333-338
NAID
Related Report
Peer Reviewed
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