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The contribution of the checkpoint genes to prostate cancer hormone resistant

Research Project

Project/Area Number 20591863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

HASHIMOTO Yoshihiro  Nagoya City University, 大学院・医学研究科, 研究員 (40244561)

Co-Investigator(Kenkyū-buntansha) TOZAWA Keiichi  名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
NAKANISHI Makoto  名古屋市立大学, 大学院・医学研究科, 教授 (40217774)
OKADA Shinsuke  名古屋市立大学, 大学院・医学研究科, 研究員 (40381818)
KOHRI Kenjiro  名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords前立腺癌 / ホルモン耐性 / チェックポイントキナーゼ / 細胞周期 / チェックポイント機構 / Chk1 / Nek6 / RNR
Research Abstract

The checkpoint mechanism of the cell cycle that surrounded the transcript of the androgen receptor to the hormone resistance of the prostate cancer was analyzed. Nek6 appeared in the peculiarity in the prostate tissue, and was located in 33-34 chromosome. The amount of the Nek6 appearance decreases in androgen non-dependency prostate cancer cell LNCaP-HR with about 80% of LNCaP by 50% or less of LNCaP. The amount of appearance of Chk1 has decreased in the hormone resistance prostate cancer tissues. Moreover, it was a gene that Nek6 is located in the upstream of Chk1 because Nek6 induced the appearance of Chk1 and the phosphorylation of Chk1 with in vitro, and the possibility of controlling S period by the appearance of RNR was suggested.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (7 results)

  • [Journal Article] Embryonal rhabdomyosarcoma of the prostate.2010

    • Author(s)
      Niimi K, Hashimoto Y, Kurokawa S, Okada A, Tozawa K, Kohri K
    • Journal Title

      Int J Clin Oncol. 15

      Pages: 93-96

    • NAID

      10027201799

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo.2010

    • Author(s)
      Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Nakanishi M
    • Journal Title

      EMBO J. 29(20)

      Pages: 3558-3570

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.2010

    • Author(s)
      Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M
    • Journal Title

      Genes Dev. 24

      Pages: 333-338

    • NAID

      130007000033

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Embryonal rhabdomyosarcoma of the prostate.2010

    • Author(s)
      Niimi K, Hashimoto Y, et al.
    • Journal Title

      Int J Clin Oncol.

      Volume: 15 Pages: 93-96

    • NAID

      10027201799

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Embryonal rhabdomyosarcoma of the prostate2010

    • Author(s)
      Niimi K, Hashimoto Y, et al.
    • Journal Title

      Int J Clin Oncol. 15

      Pages: 93-96

    • NAID

      10027201799

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantages of second line estramustine for overall survival of hormone-refractory prostate cancer(HRPC)patients2009

    • Author(s)
      Naiki T, Hashimoto Y, et al.
    • Journal Title

      Asian Pac J Cancer Prev. 10

      Pages: 71-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer.2008

    • Author(s)
      Nagata D, Hashimoto Y, Nakanishi M, Naruyama H, Okada S, Ando R, Tozawa K, Kohri K
    • Journal Title

      Cancer Detect Prev. 32

      Pages: 259-266

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Chk1 in S phase progression through regulation of RNR2 expression.2008

    • Author(s)
      Naruyama H, Hashimoto Y, Shimada M, Niida H, Zineldeen DH, Kohri K, Nakanishi M
    • Journal Title

      Biochem Biophys Res Commun. 374

      Pages: 79-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inverse relationship between obesity and serum prostate-specific antigen level in healthy Japanese men : a hospital-based cross-sectional survey, 2004-2006.2008

    • Author(s)
      Ando R, Hashimoto Y, Itoh Y, Umemoto Y, Ikeda N, Tozawa K, Kohri K, Tokudome S
    • Journal Title

      Urology. 72

      Pages: 561-565

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.2008

    • Author(s)
      Shimada M, Niida H, Zineldeen DH, Tagami H, Tanaka M, Saito H, Nakanishi M
    • Journal Title

      Cell. 132

      Pages: 221-232

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.2008

    • Author(s)
      Shimada M, Yamada-Namikawa C, Murakami-Tonami Y, Yoshida T, Nakanishi M, Urano T, Murakami H
    • Journal Title

      EMBO J. 27

      Pages: 132-142

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Chk1 in S phase progression through regulation of RNR2 expression.2008

    • Author(s)
      Naruyama H, Hashimotoy, et al.
    • Journal Title

      Biochem Biophys Res Commun. 374

      Pages: 79-83

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverse relationship between obesity and serum prostate-specific antigen level in healthy Japanese men : a hospital-based cross-sectional survey, 2004-2006.2008

    • Author(s)
      Ando R, Hashimoto y, etal.
    • Journal Title

      Urology. 72

      Pages: 561-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma and growth in hibition by its ligands in prostate cancer.2008

    • Author(s)
      Hashimoto y, Nagata D, et al.
    • Journal Title

      Cancer Detect Prev. 32

      Pages: 259-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 再発転移性尿路上皮癌に対するGemicitabine/Pacritaxel併用療法の役割2010

    • Author(s)
      河合憲康、戸澤啓一、永田大介、黒川覚史、丸山哲史、橋本良博、郡健二郎
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      岩手県盛岡市・いわて県民情報交流センター
    • Related Report
      2010 Final Research Report
  • [Presentation] Overexpression of Cdc25A, an Androgen Receptor Coactivator, in Prostate Cancer2009

    • Author(s)
      Hashimoto Yoshihiro
    • Organizer
      第104回米国泌尿器科学会議(AUA)
    • Place of Presentation
      Chicago
    • Year and Date
      2009-04-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 尿路上皮癌に対するセカンドライン化学療法としてのGemcitabine-Docetaxel療法の検討2009

    • Author(s)
      橋本良博、戸澤啓一、安藤亮介、池上要介、岡田真介、内木拓、河合憲康、岡村武彦、郡健二郎
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜市・パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Overexpress of Cdc25A, an androgen receptor coactivator, in human prostage cancer.2009

    • Author(s)
      橋本良博, 戸澤啓一, 林祐太郎, 郡健二郎
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      McCormick Place Convention Center, Chicago (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] 進行性尿路上皮癌に対するセカンドライン化学療法としてのGemcitabine-Docetaxel (GD)療法の経験2009

    • Author(s)
      橋本良博、戸澤啓一、安藤亮介、池上要介、岡田真介、林祐太郎、郡健二郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山市・岡山コンベンションセンター
    • Related Report
      2010 Final Research Report
  • [Presentation] 前立腺癌におけるSteroid Receptor Co-activatorファミリーの役割2008

    • Author(s)
      橋本 良博
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 前立腺癌におけるSteroid Receptor Co-activatorファミリーの役割2008

    • Author(s)
      橋本良博、成山泰道、安藤亮介、岡田真介、戸澤啓一、郡健二郎
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市・パシフィコ横浜
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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