Proteomic study of novel biomarkers for bladder cancer

• Project/Area Number: 20591865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kitasato University
• Principal Investigator: BABA Shiro Kitasato University, 医学部, 教授 (00051889)
• Co-Investigator(Kenkyū-buntansha): TUMURA Hideyasu 北里大学, 医学部, 助教 (20348569) ; MATSUMOTO Kazumasa 北里大学, 医学部, 講師 (70306603) ; TABATA Kenichi 北里大学, 医学部, 助教 (20327414) ; KODERA Yoshio 北里大学, 理学部, 准教授 (60265733) ; MAEDA Tadakazu 北里大学, 理学部, 教授 (90265728) ; OKUSA Hiroshi 北里大学, 医学部, 助教 (70337963)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 膀胱癌 / プロテオミクス / 腫瘍マーカー / 腎細胞癌

Research Abstract

Seven new biomarkers specific for bladder cancer were found, and the sensitivity was tested by immunohistochemistry. The diagnostic accuracy of conventional urine cytology can be increased by adding immunostaining of ant-SMC3.

Research Products

• [Journal Article] Proteomic study of sera from patients with bladder cancer-Usefulness of S100A8 and S100A9 proteins (2010)
  • Author(s): Minami S, Sato Y, Matsumoto T, Kageyama T, Kawashima Y, Yoshio K, Ishii J, Matsumoto K, Nagashio R, Okayasu T
  • Journal Title: Cancer Genomics Proteomics 7巻 Pages: 181-189
• [Journal Article] 尿のプロテオ-ム解析法開発から診断マーカー獲得に向けて (2010)
  • Author(s): 小寺義男、大草洋
  • Journal Title: 日本腎臓学会誌 52巻 Pages: 480-484
  • NAID: 10026409248
  • Peer Reviewed
• [Journal Article] Prognostic Role of Lymphovascular Invasion in Patients with Urothelial Carcinoma of the Upper Urinary Tract : An International Validation Study (2010)
  • Author(s): Novara G, Matsumoto K, Kassouf W, Walton TJ, Fritsche HM, Bastian PJ, Martinez-Salamanca JI, Seitz C, Lemberger RJ, Burger M, El-Hakim A, Baba S, Martignoni G, Gupta A, Karakiewicz PI, Ficarra V, Shariat SF.
  • Journal Title: EUROPEAN UROLOGY 57巻 Pages: 1064-1071
• [Journal Article] Proteomic study of sera from patients with bladder cancer-Usefulness of S100A8 and S100A9 proteins (2010)
  • Author(s): Minami S, ほか4名, Kodera Y
  • Journal Title: Cancer Genomics Proteomics Volume: 7 Pages: 181-189
  • Peer Reviewed
• [Journal Article] 尿のプロテオーム解析法開発から診断マーカー獲得に向けて (2010)
  • Author(s): 小寺義男、大草洋
  • Journal Title: 日本腎臓学会誌 Volume: 52 Pages: 480-484
  • NAID: 10026409248
  • Peer Reviewed
• [Journal Article] Prognostic Role of Lymphovascular Invasion in Patients with Urothelial Carcinoma of the Upper Urinary Tract : An International Validation Study. (2010)
  • Author(s): Giacomo Novara, Kazumasa Matsumoto, ほか16名
  • Journal Title: EUROPEAN UROLOGY Volume: 57 Pages: 1064-1071
  • Peer Reviewed
• [Journal Article] Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer (2009)
  • Author(s): Kazumasa Matsumoto, Shiro Baba
  • Journal Title: UROLOGY 72巻 Pages: 444-449
  • Peer Reviewed
• [Journal Article] Caveol in-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells (2009)
  • Author(s): Li L, Tabata K, Thompson TC
  • Journal Title: Mol Cancer Res 7巻 Pages: 1781-1791
  • Peer Reviewed
• [Journal Article] Distribution of lymphatic Vessel Network in Normal Urinary Bladder (2009)
  • Author(s): Matsumoto K, Baba S.
  • Journal Title: UROLOGY 72 Pages: 706-710
  • Peer Reviewed
• [Journal Article] Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer. (2009)
  • Author(s): Kazumasa Matsumoto, Shiro Baba
  • Journal Title: UROLOGY 72 Pages: 444-449
  • Peer Reviewed
• [Journal Article] Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells. (2009)
  • Author(s): Li L, Tabata K, Thompson TC.
  • Journal Title: Mol Cancer Res. 7 Pages: 1781-1791
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 松本和将、岩村正嗣、馬場志郎
  • Journal Title: 腎細胞癌および上部尿路癌の手術 新Urologic Surgeryシリーズ3(株式会社メジカルビュー社) Pages: 167-173
• [Journal Article] Current gene therapy for bladder cancer. (2008)
  • Author(s): Matsumoto K, Irie A, Satoh T, Iwamura M, Baba S
  • Journal Title: New Gene Therapy and Cancer Researchlnc Pages: 183-204
  • Peer Reviewed
• [Journal Article] Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer (2008)
  • Author(s): Matsumoto K, Satoh T, Irie A, Ishii J, Kuwao S, Iwamura M, Baba S.
  • Journal Title: UROLOGY 72巻 Pages: 440-449
  • Peer Reviewed
• [Journal Article] Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry (2008)
  • Author(s): Oh-Ishi M, Kodera Y, Furudate S, Maeda T.
  • Journal Title: Proteomics Clin Appl 2巻 Pages: 327-337
  • Peer Reviewed
• [Journal Article] Searching for new biomarekers of bladder cancer based on proteomic analysis (2008)
  • Author(s): Okusa H, Kodera Y, Oh-Ishi M, Minamida S, Tsuchida M, Kavoussi N, Matsumoto K, Sato T, Iwamura M, Maeda T, Baba S.
  • Journal Title: Journal of electorophoresis 52巻 Pages: 19-24
  • Peer Reviewed
• [Journal Article] Current gene therapy for bladder cancer (2008)
  • Author(s): Matsumoto K, et al.
  • Journal Title: New Gene Therapy and Cancer Research 無 Pages: 183-204
  • Peer Reviewed
• [Journal Article] Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer (2008)
  • Author(s): Kazumasa Matsumoto, et al
  • Journal Title: UROLOGY 72 Pages: 444-449
  • Peer Reviewed
• [Journal Article] Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry (2008)
  • Author(s): Oh-Ishi M, Kodera Y, et al
  • Journal Title: Proteomics Clin Appl 2 Pages: 327-337
  • Peer Reviewed
• [Presentation] 当院における経尿道的膀胱腫瘍切除術クリニカルパスの有用性の検討 (2010)
  • Author(s): 大草洋、藤城貴教、杉田敦、前山良太、後藤弘江、佐藤瑞穂、高野靖悟
  • Organizer: 第11回日本クリニカルパス学会
  • Place of Presentation: 松山
  • Year and Date: 2010-12-03
• [Presentation] Structual maintenance of Chromsomes 3の膀胱癌新規腫瘍マーカーとしての有用性の検討 (2010)
  • Author(s): 大草洋、松本和将、服部学、小寺義男、佐藤江梨奈、南田諭、佐藤威文、前田忠計、馬場志郎
  • Organizer: 第75回日本泌尿器科学会東部総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2010-09-16
• [Presentation] PROTEOMIC RESEARCH FOR DIAGNOSTIC MARKERS : INCREASED EXPRESSION OF S100A8/9 IS ASSOCIATED WITH DISEASE PROGRESSION AND CANCER-SPECIFIC SURVIVAL IN BLADDER CANCER (2010)
  • Author(s): 松本和将
  • Organizer: Annual Meeting American Urological Association
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2010-05-30
• [Presentation] PROTEOMIC RESEARCH FOR DIAGNOSTIC MARKERS : INCREASED EXPRESSION OF S100A8/9 IS ASSOCIATED WITH DISEASE PROGRESSION AND CANCER-SPECIFIC SURVIVAL IN BLADDER CANCER. (2010)
  • Author(s): 松本和将
  • Organizer: Annual Meeting American Urological Association
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2010-05-30
• [Presentation] Structual maintenance of Chromsomes 3の膀胱癌腫瘍マーカーとしての有用性の検討 (2010)
  • Author(s): 大草洋、松本和将、服部学、小寺義男、南田諭、大橋和也、川島佑介、佐藤絵梨奈、藤田哲夫、岩村正嗣、大石正道、前田忠計、馬場志郎
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-30
• [Presentation] 前立腺がん治療とLUTS (2009)
  • Author(s): 馬場志郎
  • Organizer: 第74回日本泌尿器科学会東部総会
  • Place of Presentation: 長野県松本文化会館(長野)
  • Year and Date: 2009-10-29
• [Presentation] DPCからみた代表的な入院泌尿器科手術の医療経済解析 (2008)
  • Author(s): 馬場志郎、岩村正嗣
  • Organizer: 第22回日本Endourology・ESWL学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-11
• [Book] 今日の治療指針2010年版 (2010)
  • Author(s): 馬場志郎
  • Publisher: 医学書院
• [Book] 今日の治療指針 2010年版 (2010)
  • Author(s): 馬場志郎
  • Publisher: 医学書院
• [Book] 腎細胞癌および上部尿路癌の手術 新Urologic Surgeryシリーズ3 (2009)
  • Author(s): 松本和将、岩村正嗣、馬場志郎
  • Publisher: 株式会社メジカルビュー社
• [Patent(Industrial Property Rights)] 体液試料における、低分子量タンパク質及びペプチドの濃縮方法 (2010)
  • Inventor(s): 小寺義男,前田忠計,川島祐介
  • Industrial Property Rights Holder: 学校法人北里研究所
  • Filing Date: 2010-08-20