Development of novel gene therapy for hormone refractory prostate cancer

• Project/Area Number: 20591868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: KIYOTA Hiroshi Jikei University School of Medicine, 医学部, 准教授 (30153240)
• Co-Investigator(Kenkyū-buntansha): KIMURA Takahiro 東京慈恵会医科大学, 医学部, 助教 (00307430) ; MIKI Jun 東京慈恵会医科大学, 医学部, 助教 (00328361)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 癌 / 泌尿器科 / 前立腺癌 / 遺伝子治療

Research Abstract

The aim of this study is to develop the new gene therapy using lentiviral vector with prostate-specific promoter that induces therapeutic gene to prostate cancer specifically. Lentiviral vectors with prostate-specific promoters were constructed and the efficiency was observed in vitro and in vivo models.