| Project/Area Number |
20591869
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nihon University |
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Principal Investigator |
TAKAHASHI Satoru Nihon University, 医学部, 教授 (50197141)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Satoshi 東京大学, 医学部・附属病院, 特任教授 (40251251)
URANO Tomohiko 東京大学, 医学部・附属病院, 特任助教 (20334386)
HIRANO Daisaku 日本大学, 医学部, 准教授 (40228804)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 腫瘍学 / ゲノム / 前立腺癌 / Androgen / 2011 / 10 / 01 / ACSL3 / ARFGAP3 / 前立腺 / Oct1 / アンドロゲンレセプター / Amyloid Precursor Protein / アンドロゲン / エストロゲン / estrogen-related receptors / estrogen receptor-binding fragment-associated gene 9 / ETS family / Oct-1 / androgen / estrogen / P450 / APP / EBAG9 |
|---|
| Research Abstract |
(1) We demonstrated the differential expression of estrogen receptor-related protein in prostate cancer. (2) We evaluated CYP3A4 expression in human prostrate cancer tissues. (3) We identified amyloid precursor protein and ARFGAP3 as a primary androgen targetandrogen target genes that are directly regulated by AR in LNCaP cells, by combining chromatin immunoprecipitation (ChIP) with tiling micro-arrays (ChIP-chip). (4) We identified Oct1 correlates with the poorer survival prognosis of the prostate cancer patients.
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