| Project/Area Number |
20591871
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Hyogo College of Medicine |
|---|
Principal Investigator |
TERAO Shuji Hyogo College of Medicine, 医学部, 助教 (10457103)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
GOTOH Akinobu 兵庫医科大学, 医学部, 教授 (70283885)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUJISAWA Masato 神戸大学, 医学部, 教授 (30243314)
TAGAWA Masatoshi 千葉県がんセンター, 病理研究部, 部長 (20171572)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 膀胱癌 / 遺伝子治療 / AdMKE1a / 導入効率 / バルプロ酸Na / AdMKEla |
|---|
| Research Abstract |
In this study, we examined whether the pre-treatment of valproic acid enhance the therapeutic effect of gene therapy using adenovirus vector for bladder cancer which do not have a significant effect on therapeutic outcome of adenovirus gene therapy. Our data showed the feasibility of the enhancement of adenovirus gene therapy using the pre-treatment of valproic acid in in vitro and in vivo.
|
