Role of bone marrow stromal cells in the bladder with partial outlet obstruction

• Project/Area Number: 20591873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Hokkaido University
• Principal Investigator: MITSUI Takahiko Hokkaido University, 病院, 助教 (90421966)
• Co-Investigator(Kenkyū-buntansha): TANAKA Hiroshi 北海道大学, 病院, 講師 (60344470) ; NONOMURA Katsuya 北海道大学, 大学院・医学研究科, 教授 (60113750)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 骨髄由来細胞 / 下部尿路閉塞 / 下部尿路機能障害 / 膀胱上皮 / GFP

Research Abstract

Using rats with allogenic bone marrow transplants from transgenic rats expressing green fluorescent protein, we investigated the contributions of bone marrow derived stem cells (BMCs) to the regeneration of the bladder with partial bladder outlet obstruction (PBOO). BMCs were homed into the PBOO bladder, and those cells have potential to differentiate into the bladder tissue components such as the uroepithelium cells, the myofibroblast cells, and smooth muscle cells in the bladder with PBOO.

Research Products

• [Journal Article] Construction of neourethra using flipped anterior bladder wall tube in prepubertal girl with complete disruption of urethra. (2010)
  • Author(s): Mitsui T, Tanaka H, Moriya K, Suzuki H, Mouri G, Hashimoto A, Nonomura K.
  • Journal Title: Urology Volume: 76(1) Pages: 112-114
  • NAID: 120002261720
  • Peer Reviewed
• [Journal Article] Long-term outcome of pituitary-gonadal axis and gonadal growth in patients with hvpospadias at puberty. (2010)
  • Author(s): Moriya K, Mitsui T, Tanaka H, Nakamura M, Nonomura K.
  • Journal Title: J Urol. Volume: 184 Pages: 1610-1614
  • Peer Reviewed
• [Journal Article] 神経およびグリア前駆細胞を用いた脊髄損傷後の下部尿路機能障害治療の可能性 (2010)
  • Author(s): 三井貴彦、Birgit Neuhiber, Marian Murray, Itzhak Fiscer
  • Journal Title: 排尿障害プラクティス Volume: 18 Pages: 357-362
• [Journal Article] STROMAL CELL-DERIVED FACTOR 1 α INDUCES HOMING OF MARROW-DERIVED STROMAL CELLS TO THE PARTIALLY OBSTURCTED RAT BLADDER
  • Author(s): Sano H, Mitsui T, et al.
  • Journal Title: submitted.
  • Peer Reviewed
• [Presentation] CONTRIBUTION OF BONE MARROW DERIVED STROMAL CELLS TO THE REGENERATION OF THE BLADDER AFTER PARTIAL OUTLET OBSTRUCTION (2011)
  • Author(s): Kanno Y, Mitsui T, et al.
  • Organizer: AUA,
  • Place of Presentation: Washington DC
  • Year and Date: 2011-05-14
• [Presentation] CONTRIBUTION OF BONE MARROW DERIVED STROMAL CELLS TO THE REGENERATION OF THE BLADDER AFTER PARTIAL OUTLET OBSTRUCTION (2011)
  • Author(s): Yukiko Kanno, Takahiko Mitsui, Hiroshi Sano, Kimihiko Moriya, Hiroshi Tanaka, Katsuya Nano mura
  • Organizer: EAU
  • Place of Presentation: Vienna(Austria)
  • Year and Date: 2011-03-21
• [Presentation] CONTRIBUTION OF BONE MARROW DERIVED STROMAL CELLS TO THE REGENERATION OF THE BLADDER AFTER PARTIAL OUTLET OBSTRUCTION (2011)
  • Author(s): Kanno Y, Mitsui T, et al.
  • Organizer: EAU
  • Place of Presentation: Vienna
  • Year and Date: 2011-03-18
• [Presentation] 慢性期下部尿路閉塞膀胱における骨髄由来細胞の関与について (2008)
  • Author(s): 佐野洋、三井貴彦、他
  • Organizer: 日本排尿機能学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-12
• [Presentation] 慢性期下部尿路閉塞膀胱における骨髄由来細胞の関与について (2008)
  • Author(s): 佐野洋、三井貴彦、守屋仁彦田中博、野々村克也
  • Organizer: 第15回日本排尿機能学会
  • Place of Presentation: 東京
• [Book] 小児泌尿器科手術柿崎秀宏編Medecal View東京 (2010)
  • Author(s): 三井貴彦
  • Publisher: 内視鏡的切開術(尿道弁、尿道狭窄、尿道憩室)