Study on new treatment strategy for bladder storage dysfunction
| Project/Area Number |
20591875
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
IGAWA Yasuhiko Shinshu University, 医学部附属病院, 特任教授 (40159588)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGAWA Teruyuki 信州大学, 医学部, 特任助教 (90467142)
AIZAWA Naoki 東京大学, 医学部附属病院, 特任助教 (80595257)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 排尿学 / 膀胱蓄尿障害 / 求心性神経伝達 / 間質性膀胱炎 / 膀胱再生 |
|---|
| Research Abstract |
Electrophysiological investigation in the rat revealed that beta3-AR agonists and activation of L-arginine/NO inhibit mechanosensitive afferent nerve activities primarily originating from the bladder in response to bladder distension as well as increased afferent nerve activities induced by intravesical instillation of PGE_2 and acrolein, respectively. Freeze-injured mouse bladders implanted with human amniotic mesenchymal cells recovered morphology and function faster than control-injected bladders. CXCL10 in the bladder urothelium and urine increased in ulcer type interstitial cystitis, suggesting its possible use as a biomarker.
|
Report
(4 results)
Research Products
(63 results)
