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Can we prevent overactive bladder?

Research Project

Project/Area Number 20591880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTottori University

Principal Investigator

SAITO Motoaki  鳥取大学, 医学部, 准教授 (60273893)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Yukako  鳥取大学, 医学部, 助教 (50032214)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords過活動膀胱 / 虚血 / SHR / 排尿筋過活動 / 膀胱血流 / NGF / 急性尿閉 / K_<ATP>チャンネル開口薬 / 膀胱平滑筋 / プレコンディショニング
Research Abstract

Bladder dysfunction in a rat model caused by acute urinary retention(AUR) needs more than two weeks of recovery period, and within two weeks of induction of AUR these rats may be used as a rat overactive bladder(OAB) model. A radical scavenger, edaravone reduces the oxidative stress and prevents the bladder dysfunction caused by AUR and subsequent catheterization. K_<ATP> channel openers, nicorandil and cromakalim prevent AUR-induced bladder dysfunction via activation of K_<ATP> channels with subsequent decrease in oxidative stress and decreased induction of apoptosis. Chronic administration of a K_<ATP> channel opener, nicorandil, anα_<1A>-blocker, silodosin, and a Rho kinase inhibitor, fasdil ameliorate hypertension-related bladder dysfunction in the SHR via improvement of bladder blood flow.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (12 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Real-time monitoring of blood flow and intravesical pressure in the rat bladder2011

    • Author(s)
      Saito M, Ohmasa F, Tsounapi P, Inoue S, Kinoshita Y, Dimitriadis F, and Satoh K
    • Journal Title

      LUTS

      Volume: 3 Pages: 76-78

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bladder dysfunction after acute urinary retention in the rats : a novel over active bladder model2010

    • Author(s)
      Saito M, Shimizu S, Kinoshita Y, Satoh I, Shomori K, Dimitriadis F, and Satoh K
    • Journal Title

      Mol Cell Biochem

      Volume: 333 Pages: 109-114

    • NAID

      120002854452

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat2010

    • Author(s)
      Ohmasa F, Saito M, Shimizu S, Taniguchi S, Dimitriadis F, Satoh I, Kinoshita Y, and Satoh K
    • Journal Title

      Eur J Pharmacol

      Volume: 635 Pages: 194-197

    • NAID

      120004972621

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bladder dysfunction after acute urinary retention in the rats : a novel over active bladder model.2010

    • Author(s)
      Saito.M., Shimizu S., Kinoshita, Y., Satoh, I., Shomori, K., Dimitriadis, F., Satoh, K.
    • Journal Title

      Mol. Cell. Biochem. 333

      Pages: 109-114

    • NAID

      120002854452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.2010

    • Author(s)
      Ohmasa, F., Saito, M., Shimizu, S., Taniguchi, S., Dimitriadis, F., Satoh, I., Kinoshita, Y., Satoh.K.
    • Journal Title

      Eur.J.Pharmacol. 635

      Pages: 194-197

    • NAID

      120004972621

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder : preventive effect of edaravone, a free-radical scavenger2009

    • Author(s)
      Shimizu S, Saito M, Kinoshita Y, Kazuyama E, Tamamura M, Satoh I, and Satoh K
    • Journal Title

      BJU Int

      Volume: 104 Pages: 713-717

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicorandil ameliorates hypertension-related bladder dysfunction in the rat

    • Author(s)
      Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, and Satoh K
    • Journal Title

      Neurourol Urodyn

      Volume: (In Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat

    • Author(s)
      Inoue S, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Kinoshita Y, Satoh K, and Takenaka A
    • Journal Title

      BJU Int

      Volume: (In Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention induced bladder dysfunction in the rat

    • Author(s)
      Ohmasa F, Saito M, Ohiwa H, Tsounapi P, Shomori K, Kitatani K, Dimitriadis F, Kinoshita Y, and Satoh K
    • Journal Title

      BJU Int

      Volume: (In Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time monitoring of blood flow and intravesical pressure in the rat bladder

    • Author(s)
      Saito, M., et al
    • Journal Title

      LUTS

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Nicorandil ameliorates hypertension-related detrusor overactivity in the SHR2011

    • Author(s)
      Saito M, Ohmasa F, Tsounapi P, Inoue S, Iwata H, Kinoshita Y, and Satoh K
    • Organizer
      The 6th Pan-Pacific Continence Society(PPCS) Meeting
    • Place of Presentation
      Taipei
    • Related Report
      2010 Final Research Report
  • [Presentation] Nicorandil ameliorates detrusor overactivity in the SHR2011

    • Author(s)
      Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, and Satoh K
    • Organizer
      International Continence Society 41st Annual Meeting
    • Place of Presentation
      Glasgow
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat2011

    • Author(s)
      Inoue S, Saito M, Tsounapi P, Ohmasa F, Honda M, Kinoshita Y, Satoh K, and Takenaka A
    • Organizer
      International Continence Society 41st Annual Meeting
    • Place of Presentation
      Glasgow
    • Related Report
      2010 Final Research Report
  • [Presentation] SHRにおける膀胱血流量と排尿筋過活動に関する研究2011

    • Author(s)
      井上誠也、齊藤源顕、大政史弥、木下ゆか子、ツナピパナイオタ、松本真由子、日向信之、本田正史、佐藤慶祐、武中篤
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性尿閉時の膀胱機能障害に対するKATPチャネルへの影響.2010

    • Author(s)
      大政史弥、齊藤源顕、清水翔吾、佐藤至、木下ゆか子、佐藤慶祐
    • Organizer
      第83回 日本薬理学会年会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat2010

    • Author(s)
      Inoue S, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Kinoshita Y, Satoh K, and Takenaka A
    • Organizer
      The 6th Pan-Pacific Continence Society(PPCS) Meeting
    • Place of Presentation
      Taipei
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性尿閉時の膀胱機能障害に対するKATPチャネルへの影響2010

    • Author(s)
      大政史弥、齊藤源顕、清水翔吾、佐藤至、木下ゆか子、佐藤慶祐
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪市
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional and histological changes after acute urinary retention in the rat.2009

    • Author(s)
      Sait, M., Shimizu, S., Kinoshita, Y., Satoh, I., Satoh, K.
    • Organizer
      International Continence Society, 39th Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional and histological changes after acute urinary retention in the rat2009

    • Author(s)
      Saito M, Shimizu S, Kinoshita Y, Satoh I, and Satoh K
    • Organizer
      International Continence Society 39th Annual Meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性尿閉時の膀胱機能障害に対するKATPチャネルへの影響2009

    • Author(s)
      木下ゆか子、大政史弥、齊藤源顕、清水翔吾、谷口宗輔、佐藤至、佐藤慶祐
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      愛媛
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット急性尿閉後の膀胱機能の回復の経時変化2009

    • Author(s)
      齊藤源顕、清水翔吾、大政史弥、木下ゆか子、佐藤至、佐藤慶祐
    • Organizer
      第62回日本排尿機能学会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 急性尿閉時の膀胱機能障害に対するフリーラジカルの役割2008

    • Author(s)
      清水翔吾、齊藤源顕、木下ゆか子、和山恵美、玉村繭子、岡田晋一、佐藤至、佐藤慶祐
    • Organizer
      第15回日本排尿機能学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Remarks] 上記研究成果は英文雑誌に投稿中および、国際学会に投稿中である。

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 心房リモデリング治療薬2008

    • Inventor(s)
      久留一郎
    • Industrial Property Rights Holder
      久留一郎
    • Industrial Property Number
      2008-148303
    • Filing Date
      2008-06-05
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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