Can we prevent overactive bladder?

• Project/Area Number: 20591880
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Tottori University
• Principal Investigator: SAITO Motoaki 鳥取大学, 医学部, 准教授 (60273893)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Yukako 鳥取大学, 医学部, 助教 (50032214)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 過活動膀胱 / 虚血 / SHR / 排尿筋過活動 / 膀胱血流 / NGF / 急性尿閉 / K_<ATP>チャンネル開口薬 / 膀胱平滑筋 / プレコンディショニング

Research Abstract

Bladder dysfunction in a rat model caused by acute urinary retention(AUR) needs more than two weeks of recovery period, and within two weeks of induction of AUR these rats may be used as a rat overactive bladder(OAB) model. A radical scavenger, edaravone reduces the oxidative stress and prevents the bladder dysfunction caused by AUR and subsequent catheterization. K_<ATP> channel openers, nicorandil and cromakalim prevent AUR-induced bladder dysfunction via activation of K_<ATP> channels with subsequent decrease in oxidative stress and decreased induction of apoptosis. Chronic administration of a K_<ATP> channel opener, nicorandil, anα_<1A>-blocker, silodosin, and a Rho kinase inhibitor, fasdil ameliorate hypertension-related bladder dysfunction in the SHR via improvement of bladder blood flow.

Research Products

• [Journal Article] Real-time monitoring of blood flow and intravesical pressure in the rat bladder (2011)
  • Author(s): Saito M, Ohmasa F, Tsounapi P, Inoue S, Kinoshita Y, Dimitriadis F, and Satoh K
  • Journal Title: LUTS Volume: 3 Pages: 76-78
  • Peer Reviewed
• [Journal Article] Bladder dysfunction after acute urinary retention in the rats : a novel over active bladder model (2010)
  • Author(s): Saito M, Shimizu S, Kinoshita Y, Satoh I, Shomori K, Dimitriadis F, and Satoh K
  • Journal Title: Mol Cell Biochem Volume: 333 Pages: 109-114
  • NAID: 120002854452
  • Peer Reviewed
• [Journal Article] The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat (2010)
  • Author(s): Ohmasa F, Saito M, Shimizu S, Taniguchi S, Dimitriadis F, Satoh I, Kinoshita Y, and Satoh K
  • Journal Title: Eur J Pharmacol Volume: 635 Pages: 194-197
  • NAID: 120004972621
  • Peer Reviewed
• [Journal Article] Bladder dysfunction after acute urinary retention in the rats : a novel over active bladder model. (2010)
  • Author(s): Saito.M., Shimizu S., Kinoshita, Y., Satoh, I., Shomori, K., Dimitriadis, F., Satoh, K.
  • Journal Title: Mol. Cell. Biochem. 333 Pages: 109-114
  • NAID: 120002854452
  • Peer Reviewed
• [Journal Article] The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat. (2010)
  • Author(s): Ohmasa, F., Saito, M., Shimizu, S., Taniguchi, S., Dimitriadis, F., Satoh, I., Kinoshita, Y., Satoh.K.
  • Journal Title: Eur.J.Pharmacol. 635 Pages: 194-197
  • NAID: 120004972621
  • Peer Reviewed
• [Journal Article] Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder : preventive effect of edaravone, a free-radical scavenger (2009)
  • Author(s): Shimizu S, Saito M, Kinoshita Y, Kazuyama E, Tamamura M, Satoh I, and Satoh K
  • Journal Title: BJU Int Volume: 104 Pages: 713-717
  • Peer Reviewed
• [Journal Article] Nicorandil ameliorates hypertension-related bladder dysfunction in the rat
  • Author(s): Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, and Satoh K
  • Journal Title: Neurourol Urodyn Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat
  • Author(s): Inoue S, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Kinoshita Y, Satoh K, and Takenaka A
  • Journal Title: BJU Int Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention induced bladder dysfunction in the rat
  • Author(s): Ohmasa F, Saito M, Ohiwa H, Tsounapi P, Shomori K, Kitatani K, Dimitriadis F, Kinoshita Y, and Satoh K
  • Journal Title: BJU Int Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Real-time monitoring of blood flow and intravesical pressure in the rat bladder
  • Author(s): Saito, M., et al
  • Journal Title: LUTS Volume: (In press)
  • Peer Reviewed
• [Presentation] Nicorandil ameliorates hypertension-related detrusor overactivity in the SHR (2011)
  • Author(s): Saito M, Ohmasa F, Tsounapi P, Inoue S, Iwata H, Kinoshita Y, and Satoh K
  • Organizer: The 6th Pan-Pacific Continence Society(PPCS) Meeting
  • Place of Presentation: Taipei
• [Presentation] Nicorandil ameliorates detrusor overactivity in the SHR (2011)
  • Author(s): Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, and Satoh K
  • Organizer: International Continence Society 41st Annual Meeting
  • Place of Presentation: Glasgow
• [Presentation] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat (2011)
  • Author(s): Inoue S, Saito M, Tsounapi P, Ohmasa F, Honda M, Kinoshita Y, Satoh K, and Takenaka A
  • Organizer: International Continence Society 41st Annual Meeting
  • Place of Presentation: Glasgow
• [Presentation] SHRにおける膀胱血流量と排尿筋過活動に関する研究 (2011)
  • Author(s): 井上誠也、齊藤源顕、大政史弥、木下ゆか子、ツナピパナイオタ、松本真由子、日向信之、本田正史、佐藤慶祐、武中篤
  • Organizer: 第18回日本排尿機能学会
  • Place of Presentation: 福井市
• [Presentation] 急性尿閉時の膀胱機能障害に対するKATPチャネルへの影響. (2010)
  • Author(s): 大政史弥、齊藤源顕、清水翔吾、佐藤至、木下ゆか子、佐藤慶祐
  • Organizer: 第83回 日本薬理学会年会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-03-16
• [Presentation] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat (2010)
  • Author(s): Inoue S, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Kinoshita Y, Satoh K, and Takenaka A
  • Organizer: The 6th Pan-Pacific Continence Society(PPCS) Meeting
  • Place of Presentation: Taipei
• [Presentation] 急性尿閉時の膀胱機能障害に対するKATPチャネルへの影響 (2010)
  • Author(s): 大政史弥、齊藤源顕、清水翔吾、佐藤至、木下ゆか子、佐藤慶祐
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪市
• [Presentation] Functional and histological changes after acute urinary retention in the rat. (2009)
  • Author(s): Sait, M., Shimizu, S., Kinoshita, Y., Satoh, I., Satoh, K.
  • Organizer: International Continence Society, 39th Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2009-10-01
• [Presentation] Functional and histological changes after acute urinary retention in the rat (2009)
  • Author(s): Saito M, Shimizu S, Kinoshita Y, Satoh I, and Satoh K
  • Organizer: International Continence Society 39th Annual Meeting
  • Place of Presentation: San Francisco
• [Presentation] 急性尿閉時の膀胱機能障害に対するKATPチャネルへの影響 (2009)
  • Author(s): 木下ゆか子、大政史弥、齊藤源顕、清水翔吾、谷口宗輔、佐藤至、佐藤慶祐
  • Organizer: 第62回日本薬理学会西南部会
  • Place of Presentation: 愛媛
• [Presentation] ラット急性尿閉後の膀胱機能の回復の経時変化 (2009)
  • Author(s): 齊藤源顕、清水翔吾、大政史弥、木下ゆか子、佐藤至、佐藤慶祐
  • Organizer: 第62回日本排尿機能学会
  • Place of Presentation: 福岡市
• [Presentation] 急性尿閉時の膀胱機能障害に対するフリーラジカルの役割 (2008)
  • Author(s): 清水翔吾、齊藤源顕、木下ゆか子、和山恵美、玉村繭子、岡田晋一、佐藤至、佐藤慶祐
  • Organizer: 第15回日本排尿機能学会
  • Place of Presentation: 東京
• [Remarks] 上記研究成果は英文雑誌に投稿中および、国際学会に投稿中である。
• [Patent(Industrial Property Rights)] 心房リモデリング治療薬 (2008)
  • Inventor(s): 久留一郎
  • Industrial Property Rights Holder: 久留一郎
  • Industrial Property Number: 2008-148303
  • Filing Date: 2008-06-05