| Project/Area Number |
20591883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HISASUE Shin-ichi (2009-2010) Sapporo Medical University, 医学部, 助教 (90404673)
加藤 隆一 (2008) Sapporo Medical University, 医学部, 講師 (10315509)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Ryuichi 札幌医科大学, 医学部, 講師 (10315509)
KOBAYASHI Kou 札幌医科大学, 医学部, 研究員 (30404669)
HASHIMOTO Kouhei 札幌医科大学, 医学部, 研究員 (40404678)
久末 伸一 札幌医科大学, 医学部, 助教 (90404673)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 再生医学 / アンドロロジー / 海綿体神経 / 勃起障害 / 神経栄養因子 / neurturin / 神経再生 / 神経機能回復 / リハビリテーション / 遺伝子治療 |
|---|
| Research Abstract |
We successfully induced the cavernous nerve regeneration following cavernous nerve injury via herpes simplex virus vector-mediated delivery of neurturin. We found that cavernous nerve dissection alone caused nerve injury-related erectile dysfunction, and the inflammatory response could play the role. We also found that cohabitation with young female partner enhances the functional recovery. In the study of cavernous nerve distribution around the prostate in human, it is revealed that fiber distribution is decreased in the patients with erectile dysfunction.
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