Cavernous nerve regeneration and recovery of erectile function following cavernous nerve injury

• Project/Area Number: 20591883
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Sapporo Medical University
• Principal Investigator: HISASUE Shin-ichi (2009-2010) Sapporo Medical University, 医学部, 助教 (90404673); 加藤 隆一 (2008) Sapporo Medical University, 医学部, 講師 (10315509)
• Co-Investigator(Kenkyū-buntansha): KATO Ryuichi 札幌医科大学, 医学部, 講師 (10315509) ; KOBAYASHI Kou 札幌医科大学, 医学部, 研究員 (30404669) ; HASHIMOTO Kouhei 札幌医科大学, 医学部, 研究員 (40404678) ; 久末 伸一 札幌医科大学, 医学部, 助教 (90404673)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 再生医学 / アンドロロジー / 海綿体神経 / 勃起障害 / 神経栄養因子 / neurturin / 神経再生 / 神経機能回復 / リハビリテーション / 遺伝子治療

Research Abstract

We successfully induced the cavernous nerve regeneration following cavernous nerve injury via herpes simplex virus vector-mediated delivery of neurturin. We found that cavernous nerve dissection alone caused nerve injury-related erectile dysfunction, and the inflammatory response could play the role. We also found that cohabitation with young female partner enhances the functional recovery. In the study of cavernous nerve distribution around the prostate in human, it is revealed that fiber distribution is decreased in the patients with erectile dysfunction.

Research Products

• [Journal Article] Baseline erectile function alters the cavernous nerve quantity and distribution around the prostate. (2010)
  • Author(s): Hisasue S, Hashimoto K, Kobayashi K, Takeuchi M, Kyoda Y, Sato S, Masumori N, Tsukamoto T
  • Journal Title: J Urol 184 Pages: 2062-2067
  • Peer Reviewed
• [Journal Article] Control of cell number in the bed nucleus of the stria terminalis of mice : Role of testosterone metabolites and estrogen receptor subtypes. (2010)
  • Author(s): Hisasue S, Seney ML, Immerman E, Forger NG
  • Journal Title: J Sex Med 7 Pages: 1401-1409
  • Peer Reviewed
• [Journal Article] Clinical safety and feasibility of a newly developed, simple algorithm for decision-making on neurovascular bundle preservation in radical prostatectomy. (2010)
  • Author(s): Hashimoto K, Hisasue S, Masumori N, Kobayashi K, Kato R, Fukuta F, Takahashi A, Hasegawa T, Tsukamoto T
  • Journal Title: Jpn J Clin Oncol 40 Pages: 343-348
  • Peer Reviewed
• [Journal Article] Experimental models for the study of female and male sexual function. (2010)
  • Author(s): Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, Wallen K
  • Journal Title: J Sex Med 7 Pages: 2970-2995
  • Peer Reviewed
• [Journal Article] Characteristics and management of erectile dysfunction after various treatments for prostate cancer. (2010)
  • Author(s): Soh J, Kaiho Y, Kikuchi E, Oya M, Yoshioka K, Nakagami Y, Hatano T, Ozu C, Horiguchi Y, Namiki K, Tachibana M, Hisasue S, Tanaka N, Asakawa I
  • Journal Title: Int J Urol 17 Pages: 689-697
  • NAID: 10027259507
  • Peer Reviewed
• [Journal Article] EDの基礎と臨床加齢による神経栄養因子受容体の骨盤神経節細胞における遺伝子発現変化 (2010)
  • Author(s): 久末伸一
  • Journal Title: 自律神経 47 Pages: 86-89
• [Journal Article] Baseline erectile function alters the cavernous nerve quantity and Distribution around the prostate (2010)
  • Author(s): Hisasue S
  • Journal Title: Journal of Urology Volume: 184 Pages: 2062-2067
  • Peer Reviewed
• [Journal Article] Control of cell number in the bed nucleus of the stria terminalis of Mice : Role of testosterone metabolites and estrogen receptor subtypes (2010)
  • Author(s): Hisasue S
  • Journal Title: Journal of Sexual Medicine Volume: 7 Pages: 1401-1409
  • Peer Reviewed
• [Journal Article] Clinical safety and feasibility of a newly developed, simple algorithm for decision-making on neurovascular bundle preservation in radical prostatectomy. (2010)
  • Author(s): Hashimoto K, Hisasue S, et al.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 40 Pages: 343-348
  • Peer Reviewed
• [Journal Article] Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury. (2009)
  • Author(s): Kato R, Wolfe D, Coyle CH, Wechuck JB, Tyagi P, Tsukamoto T, Nelson JB, Glorioso JC, Chancellor MB, Yoshimura N.
  • Journal Title: Gene Ther. 16(1) Pages: 26-33
  • Peer Reviewed
• [Journal Article] Nerve injury-related erectile dysfunction following nerve-sparing radical prostatectomy : a novel experimental dissection model. (2009)
  • Author(s): Yamashita S, Kato R, Kobayashi K, Hisasue S, Arai Y, Tsukamoto T
  • Journal Title: Int J Urol. 16(11)(Epub 2009 Sep 22) Pages: 905-911
  • NAID: 10025618580
  • Peer Reviewed
• [Journal Article] 【前立腺全摘除術における海綿体神経温存・再建update】術後陰茎(ED)リハビリテーションの有用性 (2009)
  • Author(s): 加藤隆一, 久末伸一, 小林皇, 橋本浩平, 塚本泰司
  • Journal Title: 泌尿器外科 22 Pages: 139-143
  • Peer Reviewed
• [Journal Article] 根治的子宮摘除術における神経温存の下部尿路機能回復への影響 (2009)
  • Author(s): 久末伸一, 舛森直哉, 橋本浩平, 高橋聡, 伊藤直樹, 鈴木孝浩, 齋藤豪, 塚本泰司
  • Journal Title: 泌尿器外科 22 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Nerve injury-related erectile dysfunction following nerve-sparing radical prostatectomy : a novel experimental dissection model (2009)
  • Author(s): 山下慎一
  • Journal Title: International Journal of Urology 16 Pages: 905-911
  • Peer Reviewed
• [Journal Article] 根治的子宮摘除術における神経温存の下部尿路機能回復への影響 (2009)
  • Author(s): 久末伸一
  • Journal Title: 泌尿器外科 22 Pages: 61-66
• [Journal Article] 術後陰茎(ED)リハビリテーションの有用性 (2009)
  • Author(s): 加藤隆一
  • Journal Title: 泌尿器外科 22 Pages: 139-143
• [Journal Article] Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury (2009)
  • Author(s): 加藤隆一
  • Journal Title: Gene Therapy 16 Pages: 26-33
  • Peer Reviewed
• [Presentation] 海綿体神経損傷ラットモデルを用いたEDリハビリテーションの有用性の検討 (2010)
  • Author(s): 久末伸一
  • Organizer: 第21回日本性機能学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-08-27
• [Presentation] 海綿体神経損傷ラットモデルを用いたEDリハビリテーションの有用性の検討 (2010)
  • Author(s): 久末伸一
  • Organizer: 第21回日本性機能学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-08-27
• [Presentation] The distribution of neuronal NOS-positive nerve fibers around the human prostate (2009)
  • Author(s): 久末伸一
  • Organizer: 3rd International Consultation on Sexual Medicine
  • Place of Presentation: フランス(パリ)
  • Year and Date: 2009-07-10
• [Presentation] The distribution of neuronal NOS-positive nerve fibers around the human prostate (2009)
  • Author(s): 久末伸一
  • Organizer: 3^<rd> International Consultation on Sexual Medicine
  • Place of Presentation: フランス(パリ)
  • Year and Date: 2009-07-10
• [Presentation] 神経栄養因子と海綿体神経再生-ウイルスベクターを用いた研究- (2008)
  • Author(s): 加藤隆一
  • Organizer: 第17回泌尿生殖器における信号物質の局在と役割に関する研究会
  • Place of Presentation: 花巻
  • Year and Date: 2008-12-06
• [Presentation] 神経栄養因子と海綿体神経再生-ウイルスベクターを用いた研究- (2008)
  • Author(s): 加藤隆一
  • Organizer: 第17回泌尿生殖器における信号物質の局在と役割に関する研究会
  • Place of Presentation: 花巻市
  • Year and Date: 2008-12-06