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Research for signal mechanism of the KIT-positive interstitial cells and development of the new molecular target treatment for the over active bladder

Research Project

Project/Area Number 20591886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

SASAKI Shoichi  Nagoya City University, 大学院・医学研究科, 准教授 (50225869)

Co-Investigator(Kenkyū-buntansha) KUBOTA Yasue  名古屋市立大学, 大学院・医学研究科, 講師 (00381830)
KOJIMA Yoshiyuki  名古屋市立大学, 大学院・医学研究科, 講師 (60305539)
OKADA Shinsuke  名古屋市立大学, 大学院・医学研究科, 研究員 (40381818)
TAKADA Masa  名古屋市立大学, 大学院・医学研究科, 研究員 (60468254)
KOHRI Kenjiro  名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsKIT陽性間質細胞 / 細胞増殖 / Glivec / Bcr-Abl / マウス / BOO(膀胱流出路閉塞)モデル / 過活動膀胱 / KIT変異ラット / サイクロフォスファミド / ラット / SCF / Bcr-Ab1
Research Abstract

KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Research into the effect of c-kit receptor inhibitor, imatinib mesylate, on bladder function implies that KIT-positive ICCs may be therapeutic target cells to reduce bladder overactivity and that the blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (74 results)

All 2011 2010 2009 2008

All Journal Article (21 results) (of which Peer Reviewed: 13 results) Presentation (51 results) Book (2 results)

  • [Journal Article] TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats.2011

    • Author(s)
      Shibata Yasuhiro, Ugawa Shinya, Imura Makoto, Kubota Yasue, Ueda Takashi, Kojima Yoshiyuki, Ishida Yusuke, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Shimada Shoichi
    • Journal Title

      NeuroReport 185

      Pages: 1053-1057

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between expression of α1-adrenoceptor subtype mRNA and severity of lower urinary tract symptoms or bladder outlet obstruction in benign prostatic hyperplasia patients.2011

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      BJU International 104

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of α(1)-adrenoceptor Subtypes Mediating Contraction in Human Isolated Ureters.2011

    • Author(s)
      Sasaki S, Tomiyama Y, Kobayashi S, Kojima Y, Kubota Y, Kohri K
    • Journal Title

      Urology 762

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats.2011

    • Author(s)
      Shibata Yasuhiro, Ugawa Shinya, Imura Makoto, Kubota Yasue, Ueda Takashi, Kojima Yoshiyuki, Ishida Yusuke, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Shimada Shoichi
    • Journal Title

      NeuroReport

      Volume: 185 Pages: 1053-1057

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between expression of α 1-adrenoceptor subtype mRNA and severity of lower urinary tract symptoms or bladder outlet obstruction in benign prostatic hyperplasia patients2011

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      BJU International

      Volume: 107

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of α (1)-adrenoceptor Subtypes Mediating Contraction in Human Isolated Ureters2011

    • Author(s)
      Sasaki S, Tomiyama Y, Kobayashi S, Kojima Y, Kubota Y, Kohri K
    • Journal Title

      Urology

      Volume: 762

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New pharmacologic horizons in the treatment of benign prostatic hyperplasia2011

    • Author(s)
      Kojima Yoshiyuki, Hayase Masa, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      Current Drug Therapy

      Volume: 5 Pages: 262-270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 過活動膀胱患者に対するイミダフェナシンの早期治療効果の検討2010

    • Author(s)
      窪田泰江、佐々木昌一、小島祥敬、早瀬麻沙、井村誠、柴田泰宏、郡健二郎
    • Journal Title

      泌尿器外科 23

      Pages: 827-832

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膀胱排尿筋収縮とNO.2010

    • Author(s)
      矢内良昌、佐々木昌一、窪田泰江、橋谷光、郡健二郎
    • Journal Title

      排尿障害プラクティス 18

      Pages: 21-24

    • Related Report
      2010 Final Research Report
  • [Journal Article] 膀胱排尿筋収縮とNO2010

    • Author(s)
      矢内良昌、佐々木昌一、窪田泰江、橋谷光、郡健二郎
    • Journal Title

      排尿障害プラクティス

      Volume: 18 Pages: 21-24

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 過活動膀胱患者に対するイミダフェナシンの早期治療効果の検討2010

    • Author(s)
      窪田泰江、佐々木昌一、小島祥敬、早瀬麻沙、井村誠、柴田泰宏、郡健二郎
    • Journal Title

      泌尿器外科

      Volume: 23 Pages: 827-832

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with altered connexin-43 expression in the urinary bladder.2009

    • Author(s)
      Okada Shinsuke, Kojima Yoshiyuki, Hamamoto Shuzo, Mizuno Kentaro, Sasaki Shoichi, Kohri Kenjiro
    • Journal Title

      BJU International 103

      Pages: 1429-1435

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] LUTSの遺伝子診断2009

    • Author(s)
      佐々木昌一、窪田泰江、小島祥敬、郡健二郎
    • Journal Title

      Urology View 17

      Pages: 103-107

    • Related Report
      2010 Final Research Report
  • [Journal Article] 中高年女性の尿失禁2009

    • Author(s)
      窪田泰江、佐々木昌一、郡健二郎
    • Journal Title

      日本医師会雑誌 138

      Pages: 925-925

    • Related Report
      2010 Final Research Report
  • [Journal Article] α_1遮断薬の過活動膀胱への効果2009

    • Author(s)
      佐々木昌一、小島祥敬、窪田泰江
    • Journal Title

      泌尿器外科 22

      Pages: 1512-1513

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with altered connexin-43 expression in the urinary bladder2009

    • Author(s)
      Okada Shinsuke, Kojima Yoshiyuki, Hamamoto Shuzo, Mizuno Kentaro, Sasaki Shoichi, Kohri Kenjiro
    • Journal Title

      BJU International 103

      Pages: 1429-1435

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中高年女性の尿失禁2009

    • Author(s)
      窪田泰江, 佐々木昌一, 郡健二郎
    • Journal Title

      日本医師会雑誌 138

      Pages: 925-925

    • Related Report
      2009 Annual Research Report
  • [Journal Article] α_1遮断薬の過活動膀胱への効果2009

    • Author(s)
      佐々木昌一, 小島祥敬, 窪田泰江
    • Journal Title

      泌尿器外科 22

      Pages: 1512-1513

    • Related Report
      2009 Annual Research Report
  • [Journal Article] LUTSの遺伝子診断2009

    • Author(s)
      佐々木 昌一, 窪田 泰江, 小島 祥敬, 郡 健二郎
    • Journal Title

      Urology View 17

      Pages: 103-107

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction.2008

    • Author(s)
      窪田泰江, 橋谷光, Shirasawa Nobuyuki, 小島祥敬, 佐々木昌一, Mabuchi Yoshio, Soji Tsuyoshi, Suzuki Hikaru, 郡健二郎
    • Journal Title

      Neurourol Urodyn 27

      Pages: 330-340

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction.2008

    • Author(s)
      Kubota Yasue. Hashitani Hikaru, Shirasawa Nobuyuki, Kojima Yoshiyuki, Sasaki Shoichi. Mabuchi Yoshio, Soji Tsuyoshi, Suzuki Hikaru, Kohri Keniiro
    • Journal Title

      Neurourol Urodyn 27

      Pages: 330-340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of T type Ca channel expressed in bladder primary sensory neurons in the rat.2010

    • Author(s)
      柴田泰宏, 井村誠, 早瀬麻沙, 窪田泰江, 小島祥敬, 佐々木昌一, 郡健二郎
    • Organizer
      Nagoya Shinshu Forum 2010
    • Related Report
      2010 Final Research Report
  • [Presentation] 膀胱支配一次知覚神経上のT型Caチャンネルの役割と過活動膀胱に対する新規治療ターゲットの可能性2010

    • Author(s)
      柴田泰宏、小島祥敬、井村誠、早瀬麻沙、窪田泰江、佐々木昌一、林祐太郎、郡健二郎
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      甲府市
    • Related Report
      2010 Final Research Report
  • [Presentation] Convergence of bladder and skin primary sensory neuron expressing TRPM8.2010

    • Author(s)
      Shibata Yasuhiro, Kojima Yoshiyuki, Hamakawa Takashi, Imura Makoto, Hayase Masa, Kubota Yasue, Ueda T, Sasaki Shoichi, Ugawa S, Kohri Kenjiro
    • Organizer
      Annual Meeting of the International Continence Society
    • Place of Presentation
      Toronto(Canada)
    • Related Report
      2010 Final Research Report
  • [Presentation] Attenuation of bladder overactivity in kit (WS/WS)mutant rats.2010

    • Author(s)
      佐々木昌一, 小島祥敬, 窪田泰江, 岡田真介, 井村誠, 早瀬麻沙, 柴田泰宏, 濱川隆, 郡健二郎
    • Organizer
      Annual Meeting of the International Continence Society
    • Place of Presentation
      Toronto(Canada)
    • Related Report
      2010 Final Research Report
  • [Presentation] Attenuation fo the bladder overactivity in kit(WS/WS) mutant rats.2010

    • Author(s)
      佐々木昌一, 小島祥敬, 岡田真介, 柴田泰宏, 井村誠, 早瀬麻沙, 窪田泰江
    • Organizer
      AUA 2010 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] A kit ligan, stem cell factor as a possible mediator inducing overactive bladder.2010

    • Author(s)
      窪田泰江, 小島祥敬, 早瀬麻沙, 佐々木昌一, 郡健二郎
    • Organizer
      AUA 2010 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 膀胱支配一次知覚神経上のT型Caチャンネルの発現2010

    • Author(s)
      柴田泰宏、小島祥敬、水野健太郎、井村誠、最上徹、佐々木昌一、林祐太郎、郡健二郎
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction.2010

    • Author(s)
      窪田泰江, 橋谷光, 小島祥敬, 佐々木昌一, 早瀬麻沙, 鈴木光, 郡健二郎
    • Organizer
      The 6^<th> International Symposium on ICC
    • Place of Presentation
      Miyazaki
    • Related Report
      2010 Final Research Report
  • [Presentation] 膀胱支配一次知覚神経上のT型Caチャンネルの発現2010

    • Author(s)
      柴田泰宏、小島祥敬、水野健太郎、井村誠、最上徹、佐々木昌一、林祐太郎、郡健二郎
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      岩手県盛岡市・いわて県民情報交流センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺肥大症に対する薬剤投与前後のα1受容体サブタイプ発現量の変化-タムスロシンとナフトピジルのサブタイプ選択性と薬剤耐性に関する考察2010

    • Author(s)
      小島祥敬、佐々木昌一、柴田泰宏、井村誠、林祐太郎、郡健二郎
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      岩手県盛岡市・いわて県民情報交流センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] A kit ligan, stem cell factor as a possible mediator inducing overactive bladder2010

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Hayase Masa, Sasaki Shoichi, Kohri Kenjiro
    • Organizer
      AUA 2010 Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlation between expression of α 1-adrenoceptor subtype mRNA and severity of lower urinary tract sympotoms or bladder outlet obstruction in benign prostatic hyperplasia patients2010

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Kubota Yasue, Hayashi, Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2010 Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Change of expression levels of α 1-adrenoceptor subtypes by administration of subtype-selective α 1-adrenoceptor antagonist tamsulosin in benign prostatic hyperplasia patients2010

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2010 Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Attenuation of the bladder overactivity in kit(WS/WS) mutant rats2010

    • Author(s)
      Sasaki Shoichi, Kojima Yoshiyuki, Okada Shinsuke, Shibata Yasuhiro, Imura Makoto, Hayase Masa, Kubota Yasue
    • Organizer
      AUA 2010 Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlation between expression of alphal-adrenoceptor subtype mRNA and severity of lower urinary tract symptoms or bladder outlet obstruction in benign prostatic hyperplasia patients2010

    • Author(s)
      Kojima Yoshiyuki, Shibata Yasunori, Imura Makoto, Hayase Masa, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      Annual Meeting of the International Continence Society
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto(Canada)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Attenuation of bladder overactivity in kit(WS/WS)mutant rats2010

    • Author(s)
      Sasaki Shoichi, Kojima Yoshiyuki, Kubota Yasue, Okada Shinsuki, Imura Makoto, Hayase Masa, Shibato Yasuhiro, Hamakawa Takashi, Kohri Kenjiro
    • Organizer
      Annual Meeting of the International Continence Society
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto(Canada)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Convergence of bladder and skin primary sensory neuron expressing TRPM82010

    • Author(s)
      Shibata Yasuhiro, Kojima Yoshiyuki, Hamakawa Takashi, Imura Makoto, Hayase Mass, Kubota Yasue, Uada T, Sasaki Shoichi, Ugawa S, Kohri Kenjiro
    • Organizer
      Annual Meeting of the International Continence Society
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto(Canada)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膀胱支配一次知覚神経上のT型Caチャンネルの役割と過活動膀胱に対する新規治療ターゲットの可能性2010

    • Author(s)
      柴田泰宏、小島祥敬、井村誠、早瀬麻沙、窪田泰江、佐々木昌一、林祐太郎、郡健二郎
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      山梨県甲府市・甲府富士屋ホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] Freqhency Volume Chartからみた前立腺肥大症に対する塩酸タムスロシンの長期成績2010

    • Author(s)
      小島祥敬、井村誠、柴田泰宏、佐々木昌一、林祐太郎、郡健二郎
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      山梨県甲府市・甲府富士屋ホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺肥大症におけるカルシウム活性化カリウムチャネル阻害薬の効果2010

    • Author(s)
      丹羽里実、大矢進、小島祥敬、佐々木昌一、櫻木求、郡健二郎、今泉祐治
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      山梨県甲府市・甲府富士屋ホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of T type Ca channel expressed in bladder primary sensory neuruns in the rat2010

    • Author(s)
      Shibata Yasuhiro, Imura Makoto, Hayase Masa, Kubota Yasue, Kojima Yoshiyuki, Sasaki Shoichi, Kohri Kenjiro
    • Organizer
      Nagoya Shinshu Forum 2010
    • Place of Presentation
      松本市・信州大学医学部付属病院
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺肥大症に対するα1遮断薬の長期有効性の予測因子2010

    • Author(s)
      小島祥敬、柴田泰宏、井村誠、早瀬麻沙、窪田泰江、佐々木昌一、林祐太郎、郡健二郎
    • Organizer
      第60回日本泌尿器科学会中部総会
    • Place of Presentation
      名古屋市・名古屋マリオットアソシアホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction2010

    • Author(s)
      Kubota Yasue, Hashitani Hikaru, Kojima Yoshiyuki, Sasaki Shoichi, Hayase Masa, Suzuki Hikaru, Kohri Kenjiro
    • Organizer
      The 6^<th> International Symposium on ICC
    • Place of Presentation
      シーガイヤリゾート(宮崎市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢と夜間頻尿 -夜間頻尿の危険性と臨床におけるチェックポイント-2009

    • Author(s)
      佐々木昌一
    • Organizer
      第3回加齢と下部尿路疾患を考える会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス膀胱平滑筋の自発活動におけるK channelの役割2009

    • Author(s)
      早瀬麻沙、橋谷光、柴田泰宏、井村誠、窪田泰江、小島祥敬、伊藤恭典、佐々木昌一、鈴木光、郡健二郎
    • Organizer
      第16回日本排尿機能学会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] 過活動膀胱におけるKit陽性間質細胞の役割2009

    • Author(s)
      窪田泰江、小島祥敬、早瀬麻沙、佐々木昌一、橋谷光、鈴木光、郡健二郎
    • Organizer
      第51回日本平滑筋学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス膀胱平滑筋の自発活動制御におけるK channelの役割2009

    • Author(s)
      早瀬麻沙、橋谷光、山田健司、窪田泰江、小島祥敬、伊藤恭典、佐々木昌一、郡健二郎、鈴木光
    • Organizer
      第51回日本平滑筋学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with alteration of connexin-43 expression in the urinary bladder.2009

    • Author(s)
      岡田真介, 小島祥敬, 濱本周造, 水野健太郎, 窪田泰江, 佐々木昌一, 津ヶ谷正行, 郡健二郎
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] cyclophosphamide誘発膀胱炎モデルラットにおけるKIT陽性間質細胞の役割2009

    • Author(s)
      岡田真介、小島祥敬、濱川隆、伊藤尊一郎、柴田泰宏、井村誠、早瀬麻沙、窪田泰江、佐々木昌一、津ヶ谷正行、郡健二郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山市
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス膀胱平滑筋の自発活動制御におけるK channelの役割2009

    • Author(s)
      早瀬麻沙、橋谷光、窪田泰江、小島祥敬、加藤誠、佐々木昌一、鈴木光、郡健二郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山市
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス膀胱平滑筋の自発活動制御におけるK channel の役割2009

    • Author(s)
      早瀬麻沙, 橋谷光, 窪田泰江, 小島祥敬, 加藤誠, 佐々木昌一, 鈴木光, 郡健二郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] cyclophosphamide 誘発膀胱炎モデルラットにおけるKIT陽性間質細胞の役割2009

    • Author(s)
      岡田真介, 小島祥敬, 濱川隆, 伊藤尊一郎, 柴田泰宏, 井村誠, 早瀬麻沙, 窪田泰江, 佐々木昌一, 津ヶ谷正行, 郡健二郎
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with alteration of connexin-43 expression in the urinary bladder2009

    • Author(s)
      Okada Shinsuke, Kojima Yoshiyuki, Hamamoto Shuzo, Mizuno Kentaro, Kubota Yasue, Sasaki Shoichi, Tsugaya Masayuki, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス膀胱平滑筋の自発活動制御におけるK channel の役割2009

    • Author(s)
      早瀬麻沙, 橋谷光, 山田健司, 窪田泰江, 小島祥敬, 伊藤恭典, 佐々木昌一, 郡健二郎, 鈴木光
    • Organizer
      第51回日本平滑筋学会総会
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 過活動膀胱における Kit 陽性間質細胞の役割2009

    • Author(s)
      窪田泰江, 小島祥敬, 早瀬麻沙, 佐々木昌一, 橋谷光, 鈴木光, 郡健二郎
    • Organizer
      第51回日本平滑筋学会総会
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス膀胱平滑筋の自発活動におけるK channel の役割2009

    • Author(s)
      早瀬麻沙, 橋谷光, 柴田泰宏, 井村誠, 窪田泰江, 小島祥敬, 伊藤恭典, 佐々木昌一, 鈴木光, 郡健二郎
    • Organizer
      第16回日本排尿機能学会
    • Place of Presentation
      シーホークホテル福岡(福岡市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 過活動膀胱におけるKit陽性間質細胞の役割2008

    • Author(s)
      窪田泰江、橋谷光、小島祥敬、早瀬麻沙、佐々木昌一、鈴木光、郡健二郎
    • Organizer
      第59回名古屋市立大学医学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-12-07
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 卵巣摘除ラットの排尿状態におけるisoflavone 投与の影響2008

    • Author(s)
      岡田真介、小島祥敬、濱川隆、伊藤尊一郎、柴田泰宏、井村誠、早瀬麻沙、濱本周造、水野健太郎、窪田泰江、佐々木昌一、津ヶ谷正行、郡健二郎
    • Organizer
      第58回日本泌尿器科学会中部総会
    • Place of Presentation
      大津市
    • Year and Date
      2008-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 過活動膀胱におけるイミダフェナシンの有用性の検討2008

    • Author(s)
      窪田泰江、佐々木昌一、小島祥敬、早瀬麻沙、池内隆人、山田泰之、石黒良彦、新美明達、田貫浩之、河合徹也、平尾寛昭、郡健二郎
    • Organizer
      第58回日本泌尿器科学会中部総会
    • Place of Presentation
      大津市
    • Year and Date
      2008-11-15
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] クエン酸アルベリンのモルモット膀胱平滑筋に対する作用2008

    • Author(s)
      早瀬麻沙、橋谷光、矢内良昌、窪田泰江、小島祥敬、加藤誠、佐々木昌一、鈴木光、郡健二郎
    • Organizer
      第58回日本泌尿器科学会中部総会
    • Place of Presentation
      大津市
    • Year and Date
      2008-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] クェン酸アルベリンのモルモット膀胱平滑筋に対する作用2008

    • Author(s)
      早瀬麻沙, 橋谷光, 矢内良昌, 窪田泰江, 小島祥敬, 加藤誠, 佐々木昌一, 鈴木光, 郡健二郎
    • Organizer
      第58回日本泌尿器科学会中部総会
    • Place of Presentation
      大津市
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 卵巣摘除ラットの排尿状態におけるisoflavone投与の影響2008

    • Author(s)
      岡田真介, 小島祥敬, 濱川隆, 伊藤尊一郎, 柴田泰宏, 井村誠, 早瀬麻沙, 濱本周造, 水野健太郎, 窪田泰江, 佐々木昌一, 津ヶ谷正行, 郡健二郎
    • Organizer
      第58回日本泌尿器科学会中部総会
    • Place of Presentation
      大津市
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 卵巣摘除ラット膀胱におけるisoflavone投与の影響とconnexin-43発現の変化2008

    • Author(s)
      岡田真介、小島祥敬、濱川隆、柴田泰宏、井村誠、早瀬麻沙、水野健太郎、窪田泰江、伊藤尊一郎、佐々木昌一、津ヶ谷正行、郡健二郎
    • Organizer
      第15回日本排尿機能学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Expression level and role in ureteral contraction of alpha1-adrenoceptor subtypes in human ureter.2008

    • Author(s)
      Sasaki Shoichi, Itoh Yasunori, Kojima Yoshiyuki, Kubota Yasue, Hayase Masa, Tomiyama Yoshitaka, Kobayashi Shinya, Hoyano Yuji, Yamazaki Yoshinobu, Kohri Kenjiro
    • Organizer
      AUA 2008 Annual Meeting
    • Place of Presentation
      Orland(Florida USA)
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction.2008

    • Author(s)
      窪田泰江, 小島祥敬, 佐々木昌一, 早瀬麻沙, 岡田真介, 郡健二郎
    • Organizer
      AUA 2008 Annual Meeting
    • Place of Presentation
      Orland(Florida USA)
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction.2008

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Sasaki Shoichi, Hayase Masa, Okada Shinsuke, Kohri Kenjiro
    • Organizer
      AUA 2008 Annual Meeting
    • Place of Presentation
      Orland (Florida USA)
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression level and role in ureteral contraction of alpha1-adrenoceptor subtypes in human ureter2008

    • Author(s)
      Sasaki Shoichi, Itoh Yasunori, Kojima Yoshiyuki, Kubota Yasue, Hayase Masa, Tomiyama Yoshitaka, Kobayashi Shinya, Hoyano Yuji, Yamazaki Yoshinobu, Kohri Keniiro
    • Organizer
      AUA 2008 Annual Meeting
    • Place of Presentation
      Orland (Florida USA)
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] モルモット膀胱平滑筋におけるクエン酸アルベリンの作用機序の検討2008

    • Author(s)
      早瀬麻沙、橋谷光、矢内良昌、池内隆人、佐々木昌一、鈴木光、郡健二郎
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト尿管における部位別に見た収縮力とα1-アドレナリン受容体遮断薬の効果2008

    • Author(s)
      佐々木昌一、伊藤恭典、小島祥敬、早瀬麻沙、窪田泰江、富山愛隆、小林真也、保屋野雄志、山崎芳伸、郡健二郎
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 過活動膀胱に対するKitチロシンキナーゼ阻害薬の作用機序の解明と治療薬への可能性2008

    • Author(s)
      窪田泰江、岡田淳志、佐々木昌一、郡健二郎
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] モルモット膀胱平滑筋におけるクェン酸アルベリンの作用機序の検討2008

    • Author(s)
      早瀬麻沙, 橋谷光, 矢内良昌, 池内隆人, 佐々木昌一, 鈴木光, 郡健二郎
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-26
    • Related Report
      2008 Annual Research Report
  • [Book] Horizons in Cancer Research.(New Insights into Alpha1-Adrenoceptor sobtypes and pharmacogenomics of benign prostatic hyperplasia.)(Morrison EP(eds))2010

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2010 Final Research Report
  • [Book] New Insights into Alphal-Adrenoceptor sobtypes and pharmacogenomics of benign prostatic hyperplasia2010

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Publisher
      Horizons in Cancer Research(Morrison EP(eds))(Nova Science Publishers, Inc.)
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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