| Project/Area Number |
20591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
YASUI Takahiro Nagoya City University, 大学院・医学研究科, 講師 (40326153)
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| Co-Investigator(Kenkyū-buntansha) |
TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
ITOH Yasunori 名古屋市立大学, 大学院・医学研究科, 研究員 (70295608)
OKADA Atsushi 名古屋市立大学, 大学院・医学研究科, 助教 (70444966)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 尿路結石 / ミトコンドリア / オステオポンチン / 酸化ストレス / 透過型電子顕微鏡 / 遺伝子組み換え |
|---|
| Research Abstract |
Renal tubular cell injury, especially mitochondrial damage, and oxidative stress induce the early stage of calcium oxalate crystal formation in mice. We investigated the effects of impaired domains of OPN, the RGD sequence and two calcium-binding sites on crystal formation. Each domain contributes to the mechanism by which OPN stimulates crystal formation.
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