Evaluation of urinary stone formation with respect to oxidative stress and analysis of osteopontin function using transgenic mice.
| Project/Area Number |
20591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
YASUI Takahiro Nagoya City University, 大学院・医学研究科, 講師 (40326153)
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| Co-Investigator(Kenkyū-buntansha) |
TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
ITOH Yasunori 名古屋市立大学, 大学院・医学研究科, 研究員 (70295608)
OKADA Atsushi 名古屋市立大学, 大学院・医学研究科, 助教 (70444966)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 尿路結石 / ミトコンドリア / オステオポンチン / 酸化ストレス / 透過型電子顕微鏡 / 遺伝子組み換え |
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| Research Abstract |
Renal tubular cell injury, especially mitochondrial damage, and oxidative stress induce the early stage of calcium oxalate crystal formation in mice. We investigated the effects of impaired domains of OPN, the RGD sequence and two calcium-binding sites on crystal formation. Each domain contributes to the mechanism by which OPN stimulates crystal formation.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice ; detection by association analysis of stone-related gene expression and microstructural observation.2010
Author(s)
Atsushi Okada, Takahiro Yasui, Yasuhiro Fujii, Kazuhiro Niimi, Shuzo Hamamoto, Masahito Hirose, Yoshiyuki Kojima, Yasunori Itoh, Keiichi Tozawa, Yutaro Hayashi, Kenjiro Kohri
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Journal Title
J Bone Miner Res. 25(12)
Pages: 2425-2435
Related Report
Peer Reviewed
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[Presentation] The role of long-term loading of cholesterol in renal crystal formation.2009
Author(s)
伊藤恭典, 吉村麦, 新美和寛, 宇佐美雅之, 浜本周造, 小林隆宏, 広瀬真仁, 岡田淳志, 安井孝周, 戸澤啓一, 郡健二郎
Organizer
6th eULIS Symposium (13th European Symposium on Urolithiasis)
Place of Presentation
Lake of Como/Lecco, in Italy(Oct 15)
Related Report
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[Presentation] The role of NF-κB on renal stone formation.2009
Author(s)
戸澤啓一, 安井孝周, 広瀬真仁, 宇佐美雅之, 浜本周造, 廣瀬泰彦, 岡田淳志, 伊藤恭典, 小林隆宏, 郡健二郎
Organizer
2009 (104^<th>) Annual Meeting of American Urological Association
Place of Presentation
Cicago, Irinoi, USA(4.29)
Related Report
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[Presentation] Osteopontin has an important role in kidney stone formation and elimination via renal macrophage recruitment and activation.2009
Author(s)
岡田淳志, 戸澤啓一, 新美和寛, 廣瀬泰彦, 小林隆宏, 宇佐美雅之, 浜本周造, 広瀬真仁, 伊藤恭典, 安井孝周, 小林隆宏, 郡健二郎
Organizer
2009 (104^<th>) Annual Meeting of American Urological Association
Place of Presentation
Cicago, Irinoi, USA(4.29)
Related Report
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