| Project/Area Number |
20591894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
|
|---|
| Research Institution | Akita University |
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Principal Investigator |
SATOH Shigeru Akita University, 医学部, 教授 (80187195)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIURA Masatomo 秋田大学, 医学部, 准教授 (30265194)
SAITO Mitsuru 秋田大学, 医学部, 助教 (80400505)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腎移植 / 慢性移植腎症 / 免疫抑制薬 / 移植後糖尿病 / 遺伝子多型 / 薬物動態 / 画像解析装置 / 線維増生 / 急性拒絶 |
|---|
| Research Abstract |
The previously studies showed that the CYP3A5^*1 allele was associated with the early onset of acute rejection and tacrolimus-related chronic allograft nephropathy. In contrast to those reports, our results showed that the CYP3A5^*3/^*3 genotype was associated with subclinical acute rejection and increasing interstitial fibrosis within one year after transplantation.
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