Clinical and Genomic Risk Factors for Early Onset of Chronic Allograft Nephropathy
| Project/Area Number |
20591894
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
SATOH Shigeru Akita University, 医学部, 教授 (80187195)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIURA Masatomo 秋田大学, 医学部, 准教授 (30265194)
SAITO Mitsuru 秋田大学, 医学部, 助教 (80400505)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 腎移植 / 慢性移植腎症 / 免疫抑制薬 / 移植後糖尿病 / 遺伝子多型 / 薬物動態 / 画像解析装置 / 線維増生 / 急性拒絶 |
|---|
| Research Abstract |
The previously studies showed that the CYP3A5^*1 allele was associated with the early onset of acute rejection and tacrolimus-related chronic allograft nephropathy. In contrast to those reports, our results showed that the CYP3A5^*3/^*3 genotype was associated with subclinical acute rejection and increasing interstitial fibrosis within one year after transplantation.
|
Report
(4 results)
Research Products
(41 results)
-
[Journal Article] Factors Increasing Quantitative Interstitial Fibrosis from 0-hour to 1-year in Living Kidney Transplant Patients Receiving Tacrolimus.2011
Author(s)
Miura Y, Satoh S, Saito M, Numakura K, Inoue T, Obara T, Tsuruta H, Narita S, Horikawa Y, Tsuchiya N, Komatsuda A, Kagaya H, Miura M, Habuchi T.
-
Journal Title
Transplantation 91
Pages: 78-85
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
佐藤滋
-
Journal Title
拒絶反応の分類-臨床分類、病理分類、拒絶.拒絶診断.腎移植のすべて(メジカルビュー社)
Pages: 254-269
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Clinical risk factors for increased interstitial fibrosis by computerized image analysis after renal transplantation.2010
Author(s)
Miura Y., Satoh S., Saito M., Numakura K., Tsuruta H., Obara T., Inoue T., Narita S., Horikawa Y., Tsuchiya N., Habuchi T.
Organizer
The 104th Annunal Meeting of the American Urological Association(Best of Posters Award.)
Place of Presentation
San Francisco.
Related Report
-
-
[Presentation] No impact of agen on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone one month after renal transplantation.2010
Author(s)
Satoh S., Saito M., Numakura K., Tsuruta H., Obara T., Inoue T., Narita S., Horikawa Y., Tsuchiya N., Habuchi T., Kagaya H., Miura M.
Organizer
The Annunal Meeting of the American Transplant Congress
Place of Presentation
San Diego.
Related Report
-
-
-
-
[Presentation] Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus and mycophenolate mofetil.2008
Author(s)
Shigeru Satoh, Kazuyuki Numakura, Mitsuru Saito, Takamitus Inoue, Kazuyuki Inoue, Masatomo Miura, Hideaki Kagaya, Hiroshi Tsuruta, Takashi Obara, Teruaki Kumazawa, Takeshi Yuasa, Norihiko Tsuchiya, Toshio Suzuki, Tomonori Habuchi
Organizer
The Annunal Meeting of the American Transplant Congress
Place of Presentation
Tolonto, USA
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
