Role of melanocortin system on psychologioally suppressed masculine sexual behavior

• Project/Area Number: 20591895
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: University of Fukui
• Principal Investigator: MIWA Yosiji University of Fukui, 医学部附属病院, 講師 (10209968)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA Osamu 福井大学, 医学部, 教授 (90242552) ; ITOU Hideaki 福井大学, 医学部, 助教 (00345620) ; MATSUDA Yousuke 福井大学, 医学部, 助教 (90345687)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心理ストレス / アンドロロジー / 生殖行動 / メラノコルチン系 / レプチン / Corticotropin releasing factor受容体 / 性機能障害

Research Abstract

Our study revealed that sexual behavior suppressed by psychological stress could be recovered with a melanocortin receptor agonist or a corticotropin-releasing factor receptor antagonist in male rats. We clarified a part of the mechanism of sexual behavior suppression in response to psychological stress.

Research Products

• [Journal Article] Effect of Corticotropin-Releasing Factor Receptor Antagonist on Psychologically Suppressed Masculine Sexual Behavior in Rats (2011)
  • Author(s): Yoshiji Miwa, Keiko Nagase, Nobuyuki Oyama, Hironobu Akino, Osamu Yokoyama
  • Journal Title: J Sex Med 8 Pages: 688-695
  • Peer Reviewed
• [Journal Article] Effect of Corticotropin-Releasing Factor Receptor Antagonist on Psychologically Suppressed Masculine Sexual Behavior in Rats. (2011)
  • Author(s): Yoshiji Miwa, Keiko Nagase, Nobuyuki Oyama, Hironobu Akino, Osamu Yokoyama
  • Journal Title: J Sex Med Volume: 8 Pages: 688-695
  • Peer Reviewed
• [Journal Article] Association Between Lower Urinary Tract Symptoms and Serum Levels of Sex Hormones in Men (2008)
  • Author(s): Yoshiji Miwa, Taisei Kaneda, Osamu Yokoyama
  • Journal Title: Urology 72 Pages: 552-555
  • Peer Reviewed
• [Journal Article] 性ホルモンとLUTS (2008)
  • Author(s): 三輪吉司, 横山修
  • Journal Title: Urology View 7 Pages: 18-22
• [Journal Article] 向精神薬が投与されているEDの患者です。対処と処方について教えて下さい。 (2008)
  • Author(s): 三輪吉司
  • Journal Title: 臨床泌尿器科 62 Pages: 275-277
• [Presentation] Are sleep disorders and nocturia independent risk factors for erectile dysfunction (2011)
  • Author(s): Yoshiji Miwa, Nobuyuki Oyama, Hironobu Akino, Osamu Yokoyama
  • Organizer: 106th Annual Meeting ofthe American Urological Association
  • Place of Presentation: Washington, DC, USA
• [Presentation] Effect of Corticotropin-Releasing Factor Receptor Antagonist on Sexual Behavior Suppressed by Psychological Stress in Male Rats (2010)
  • Author(s): Yoshiji Miwa, Keiko Nagase, Osamu Yokoyama
  • Organizer: The 4th Greatwall International Andrology Forum
  • Place of Presentation: Shenzhen, China
  • Year and Date: 2010-03-19
• [Presentation] Improvement of detrusor overactivity by alpha-l adrenoceptor antagonist via suppression of atp release from the bladder epithelium in aged spontaneously hypertensive rats (2008)
  • Author(s): Miwa Y, Nagase K, Kaneda T, Oyama N, Akino H, Yokoyama O
  • Organizer: International Continence Society 38th Annual Meeting
  • Place of Presentation: Cairo, EGY
  • Year and Date: 2008-10-20
• [Presentation] Effects of corticotropin-releasing factor receptor antagonists on sexual behavior suppressed by psychological stress in male rats (2008)
  • Author(s): Miwa Y, Nagase K, Kaneda T, Oyama N, Akino H, Yokoyama O
  • Organizer: AUA 2008 Annual Meeting
  • Place of Presentation: Orlando, FL,USA
  • Year and Date: 2008-05-19
• [Presentation] Effects of corticotropin-releasing factor receptor antagonists on sexual behavior suppressed by psychologicalstress in male rats (2008)
  • Author(s): Miwa Y, Nagase K, Kaneda T, Oyama N, Akino H, Yokoyama O
  • Organizer: AUA 2008 Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2008-05-19
• [Book] ED診療ガイドライン(2008) (2010)
  • Author(s): 三輪吉司
  • Publisher: 医学書院
• [Book] 今日の治療指針2010年版 (2010)
  • Author(s): 三輪吉司
  • Total Pages: 4
  • Publisher: 医学書院