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Analysis of genome maintenance of testicular stem cells in DNA deficient mice with impaired spermatogenesis.

Research Project

Project/Area Number 20591898
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTottori University

Principal Investigator

NAKANE Hironobu  Tottori University, 医学部, 助教 (10304205)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsDNA修復欠損マウス / 精子形成 / 精巣幹細胞
Research Abstract

We have showed that xeroderma pigmentosum group A (Xpa) gene-knockout mice [Xpa (-/-) mice] provide a valuable model for growth retardation, internal tumor formation, impaired spermatogenesis as well as for UV-induced skin tumors in XPA patients. Gene expression analysis of each aged Xpa mice testis showed a different expression pattern of DNA repair gene, cell cycle-related gene(checkpoint), apoptosis-related gene compared to control. We found other pathological changes of the aged Xpa mice testis. These data will help us to understand the impaired spermatogenesis in the Xpa mice.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 2 results) Presentation (18 results)

  • [Journal Article] Histopathological analysis of impaired spermatogenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice2011

    • Author(s)
      Hironobu Nakane, Kiyoji Tanaka, Toshio Kameie, Sumire Inaga, Tomonori Naguro
    • Journal Title

      The Journal of Physiological Sciences Vol.61.supple.1

    • Related Report
      2010 Final Research Report
  • [Journal Article] Differential DNA damage signaling accounts for distinct neural apoptotic responses in DNA repair deficient mice of ATLD, NBS, XPA, XPG-Insight from neuropathology of DNA repair-deficiency disorders-2011

    • Author(s)
      Hironobu Nakane
    • Journal Title

      1^<st> RIRBM International Symposium-Genome Damage and Non-Cancerous Diseases-抄録集

      Pages: 16-18

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Histopathological analysis of impaired spermatogenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice2011

    • Author(s)
      Hironobu Nakane, et al.
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 61.supple.1

    • Related Report
      2010 Annual Research Report
  • [Journal Article] コケイン症候群のモデル動物としてのXpgヌルマウスの検討2010

    • Author(s)
      中根裕信, 他
    • Journal Title

      第4回日本エピジェネティクス研究会年会要旨集

      Pages: 94-94

    • Related Report
      2010 Annual Research Report
  • [Journal Article] DNA修復異常症におけるDNA損傷応答の違いによる脳神経病委への関与-ATLD,NBS,XPAの神経病変2010

    • Author(s)
      中根裕信, 他
    • Journal Title

      BMB2010 categ2.workshop.pdf抄録集

      Pages: 134-134

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ヌクレオチド除去修復欠損マウス-転写異常とその病態-2009

    • Author(s)
      中根裕信
    • Journal Title

      医学のあゆみ 228巻

      Pages: 157-158

    • Related Report
      2010 Final Research Report
  • [Journal Article] XP・CSモデルマウスの分子病態2009

    • Author(s)
      中根裕信
    • Journal Title

      色素性乾皮症全国大会(難病指定記念講演会)報告集

      Pages: 5-5

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ヌクレオチド除去修復欠損マウス 転写異常とその病態(解説/特集)2009

    • Author(s)
      中根裕信
    • Journal Title

      医学のあゆみ 1月10日号 228

      Pages: 157-158

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.2008

    • Author(s)
      Hironobu Nakane, Seiichi Hirota, Philip J.Brooks, Yusaku Nakabeppu, Yoshimichi Nakatsu, Yoshitake Nishimune, Akihiro Iino, Kiyoji Tanaka
    • Journal Title

      DNA Repair (Amst). vol.7(No.12)

      Pages: 1938-1950

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice2008

    • Author(s)
      Nakane H., et al.
    • Journal Title

      DNA Repair 7

      Pages: 1938-1950

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Differential DNA damage signaling accounts for distinct neural apoptotic responses in DNA repair deficient mice of ATLD, NBS, XPA, XPG -Insight from neuropathology of DNA repair-deficiency disorders-2011

    • Author(s)
      中根裕信
    • Organizer
      1^<st> RIRBM Intemational Symposium -Genome Damage and Non-Cancerous Diseases- (invited speaker)
    • Place of Presentation
      Koujin Conference Hall on Kasumi Campus, Hiroshima University
    • Related Report
      2010 Final Research Report
  • [Presentation] Differential DNA damage signaling accounts for distinct neural apoptotic responses in DNA repair deficient mice of ATLD, NBS, XPA, XPG-Insight from neuropathology of DNA repair-deficiency disorders-2011

    • Author(s)
      Hironobu Nakane
    • Organizer
      1^<st> RIRBM International Symposium-Genome Damage and Non-Cancerous Diseases-
    • Place of Presentation
      Koujin Conference Hall on Kasumi Campus, Hiroshima University
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA修復異常症におけるDNA損傷応答の違いによる脳神経病変への関与-ATLD, NBS, XPAの神経病変2010

    • Author(s)
      中根裕信、Erin R.P.Shull、Youngsoo Lee、栗政明弘、稲賀すみれ、名黒知徳、田中亀代次、Peter J.McKinnon
    • Organizer
      BMB2010 workshop (招待講演)
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA修復異常症におけるDNA損傷応答の違いによる脳神経病変への関与-ATLD,NBS,XPAの神経病変2010

    • Author(s)
      中根裕信, 他
    • Organizer
      BMB2010
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 色素性乾皮症G群遺伝子欠損マウス(XPG nullマウス)の病理学的解析2010

    • Author(s)
      中根裕信、広田誠一、塩見忠博、大浜栄作、亀家俊夫、稲賀すみれ、名黒知徳
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県民会館(盛岡市)
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 色素性乾皮症G群遺伝子欠損マウス(XPG null マウス)の病理学的解析2010

    • Author(s)
      中根裕信
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県民会館(盛岡市)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] CSモデルマウスの解析2010

    • Author(s)
      中根裕信
    • Organizer
      コケイン症候群(CS)の集い2010
    • Place of Presentation
      ロレアル東京アカデミー(東京都渋谷区代々木)
    • Related Report
      2010 Final Research Report
  • [Presentation] コケイン症候群のモデル動物としてのXpgヌルマウスの検討2010

    • Author(s)
      中根裕信、広田誠一、塩見忠博、大浜栄作、亀家俊夫、稲賀すみれ、名黒知徳
    • Organizer
      第4回日本エピジェネティクス研究会
    • Place of Presentation
      米子市文化ホール(米子市)
    • Related Report
      2010 Final Research Report
  • [Presentation] コケイン症候群のモデル動物としてのXpgヌルマウスの検討2010

    • Author(s)
      中根裕信, 他
    • Organizer
      第4回日本エピジェネティクス研究会
    • Place of Presentation
      米子市文化ホール(鳥取県米子市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] CSモデルマウスの解析2010

    • Author(s)
      中根裕信
    • Organizer
      コケイン症候群(CS)の集い2010
    • Place of Presentation
      ロレアル 東京アカデミー(東京都渋谷区代々木)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice2009

    • Author(s)
      中根裕信, 広田誠一, 田中亀代次
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山理科大学(岡山県)
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice2009

    • Author(s)
      Nakane H., et al.
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山県、岡山理科大学
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] XP・CS モデルマウスの分子病態2008

    • Author(s)
      中根裕信
    • Organizer
      色素性乾皮症全国大会(難病指定記念講演会)
    • Place of Presentation
      愛知県、あいち健康プラザ
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pathological analysis of XPG-deficient mice2008

    • Author(s)
      Nakane H., et al.
    • Organizer
      The 6th 3R Symposium(3R Symposium 2008)
    • Place of Presentation
      Kakegawa, Shizuoka
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hypersensitivity to oxidative damage in the developing nervous system of XPA mice2008

    • Author(s)
      Nakane H., et al.
    • Organizer
      The International Ataxia-Telangiectasia Workshop 2008
    • Place of Presentation
      Ohtsu, Shiga
    • Year and Date
      2008-04-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] XP・CSモデルマウスの分子病態2008

    • Author(s)
      中根裕信
    • Organizer
      色素性乾皮症全国大会(難病指定記念講演会)
    • Place of Presentation
      あいち健康プラザ(愛知県)
    • Related Report
      2010 Final Research Report
  • [Presentation] Pathological analysis of XPG-deficient mice2008

    • Author(s)
      中根裕信, 広田誠一, 塩見忠博, 大浜栄作, 亀家俊夫, 稲賀すみれ, 名黒知徳
    • Organizer
      The 6^<th> 3R Symposium (3R Symposium 2008)
    • Place of Presentation
      Tsumagoi Resort (Kakegawa, Shizuoka)
    • Related Report
      2010 Final Research Report
  • [Presentation] Hypersensitivity to oxidative damage in the developing nervous system of XPA mice2008

    • Author(s)
      中根裕信, 栗政明弘, 田中亀代次
    • Organizer
      The International Ataxia-Telangiectasia Workshop 2008
    • Place of Presentation
      Ohtsu Prince Hotel (Ohtsu, Shiga)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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