The role of immune cells in endometriosis

• Project/Area Number: 20591908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: OSUGA Yutaka 東京大学, 医学部・附属病院, 准教授 (80260496)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 子宮内膜症 / 免疫 / 炎症 / Th17細胞 / IL-17 / ケモカイン / TGF-β / proteinase-activated receptor 2 / interleukin-6 / Th17 / CCR6 / CCL20

Research Abstract

(1) In a novel paradigm of T cell differentiation, type 17 T helper(Th17) cells may play a significant role in endometriosis, a chronic inflammatory disease. Our findings suggested that the CCL20/CCR6 system is involved in the migration of Th17 cells to endometriotic tissues and that proinflammatory cytokines contribute to the development of endometriosis via up-regulation of CCL20 secretion from endometriotic stromal cells.(2) Proteinase-activated receptor 2(PAR2) is a G-protein-coupled receptor that is activated by several serine proteases. PAR2 activation in endometriotic stromal cells(ESCs) has been implicated in the development of endometriosis but the regulatory mechanism of PAR2 expression in ESC is unknown. In view of significant roles of PAR2 and IL-6 in endometriosis, our finding that TGF-β1 induced increase in PAR2 expression in ESC may be an elaborate mechanism that augments the progression of the disease.(3) IL-17F increased the secretion of IL-8 from ESCs, and the effect was inhibited by antibodies for IL-17 receptor A and IL-17 receptor C. Tumor necrosis factorα(TNF-α) synergistically enhanced IL-17F-induced increase in IL-8 secretion from ESCs. The IL-17F increased the gene expression of IL-8 and COX2 in ESCs. These findings suggest that IL-17F may stimulate the development of endometriosis by up-regulation of IL-8 and COX2.(4) Inflammatory stimuli, interleukin(IL)-1β, and tumor necrosis factor(TNF)-αinduced inhibin/activin-βA subunit mRNA and activin-A protein expression in EoSC. Additionally, activin-A enhanced EoSC proliferation and increased the expression of IL-6 and protease-activated receptor(PAR)-2 mRNA. An in vitro study revealed that activin-A, which is induced by IL-1βor TNF-α, might promote endometriosis by stimulating IL-6 and PAR-2 mRNA expression and increasing the proliferation of EoSC.

Research Products

• [Journal Article] Myomectomy decreases abnormal uterine peristalsis and increases pregnancy rate (2012)
  • Author(s): Yoshino O., Nishii O., Osuga Y., Asada H., Okuda S., Orisaka M., Hori M., Fujiwara T., Hayashi T.
  • Journal Title: J Minim Invasive Gynecol Volume: 19 Pages: 63-67
  • Peer Reviewed
• [Journal Article] Activin-A is induced by interleukin-1beta and tumor necrosis factor-alpha and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma (2011)
  • Author(s): Yoshino O., Izumi G., Shi J., Osuga Y., Hirota Y., Hirata T., Harada M., Nishii O., Koga K., Taketani Y.
  • Journal Title: Fertil Steril Volume: 96 Pages: 118-121
  • Peer Reviewed
• [Journal Article] Myomectomy reduces endometrial T2 relaxation times (2011)
  • Author(s): Yoshino O., Hori M., Osuga Y., Hayashi T., Sadoshima Y., Tsuchiya H., Nishii O., Taketani Y.
  • Journal Title: Fertil Steril Volume: 95 Pages: 2781-2783
  • Peer Reviewed
• [Journal Article] Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis (2011)
  • Author(s): Hirata T., Osuga Y., Takamura M., Saito A., Hasegawa A., Koga K., Yoshino O., Hirota Y., Harada M., Taketani Y.
  • Journal Title: Fertil Steril Volume: 96 Pages: 113-117
  • Peer Reviewed
• [Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis : a pilot study (2011)
  • Author(s): Harada M., Osuga Y., Izumi G., Takamura M., Takemura Y., Hirata T., Yoshino O., Koga K., Yano T., Taketani Y.
  • Journal Title: Gynecol Endocrinol Volume: 27 Pages: 717-20
  • Peer Reviewed
• [Journal Article] High mobility group box 1(HMGB1) levels in the placenta and in serum in preeclampsia (2011)
  • Author(s): Wang B., Koga K., Osuga Y., Hirata T., Saito A., Yoshino O., Hirota Y., Harada M., Takemura Y., Fujii T., Taketani Y.
  • Journal Title: Am J Reprod Immunol Volume: 66 Pages: 143-148
  • Peer Reviewed
• [Journal Article] Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts (2011)
  • Author(s): Wang B., Koga K., Osuga Y., Cardenas I., Izumi G., Takamura M., Hirata T., Yoshino O., Hirota Y., Harada M., Mor G., Taketani Y.
  • Journal Title: Endocrinology Volume: 152 Pages: 4984-4992
  • Peer Reviewed
• [Journal Article] Sessile polyps and pedunculated polyps respond differently to oral contraceptives (2011)
  • Author(s): Wada-Hiraike O., Osuga Y., Hiroi H., Fujimoto A., Maruyama M., Yano T., Taketani Y.
  • Journal Title: Gynecol Endocrinol Volume: 27 Pages: 351-5
  • Peer Reviewed
• [Journal Article] Successful management of a ruptured endometrial cyst in acute leukemia (2011)
  • Author(s): Taguchi A., Koga K., Osuga Y., Fujimoto A., Miyasaka A., Yano T., Kurokawa M., Taketani Y.
  • Journal Title: Fertil Steril Volume: 95
  • Peer Reviewed
• [Journal Article] Bone Morphogenetic Protein-2(BMP-2) Increases Gene Expression of FSH Receptor and Aromatase and Decreases Gene Expression of LH Receptor and StAR in Human Granulosa Cells (2011)
  • Author(s): Shi J., Yoshino O., Osuga Y., Koga K., Hirota Y., Nose E., Nishii O., Yano T., Taketani Y.
  • Journal Title: Am J Reprod Immunol Volume: 65 Pages: 421-7
  • Peer Reviewed
• [Journal Article] GF-beta1 induces proteinase-activated receptor 2(PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 (2011)
  • Author(s): Saito A., Osuga Y., Yoshino O., Takamura M., Hirata T., Hirota Y., Koga K., Harada M., Takemura Y., Yano T., Taketani Y.
  • Journal Title: Hum Reprod Volume: 26 Pages: 1892-1898
  • Peer Reviewed
• [Journal Article] Death effector domain-containing protein(DEDD) is required for uterine decidualization during early pregnancy in mice (2011)
  • Author(s): Mori M., Kitazume M., Ose R., Kurokawa J., Koga K., Osuga Y., Arai S., Miyazaki T.
  • Journal Title: J Clin Invest Volume: 121 Pages: 318-327
• [Journal Article] Y : Bone morphogenetic protein 7(BMP-7) increases the expression of follicle-stimulating hormone(FSH) receptor in human granulosa cells (2010)
  • Author(s): Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 93 Pages: 1273-9
  • Peer Reviewed
• [Journal Article] Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids (2010)
  • Author(s): Yoshino O., Hayashi T., Osuga Y., Orisaka M., Asada H., Okuda S., Hori M., Furuya M., Onuki H., Sadoshima Y., Hiroi H., Fujiwara T., Kotsuji F., Yoshimura Y., Nishii O., Taketani Y.
  • Journal Title: Hum Reprod Volume: 25 Pages: 2475-2479
  • Peer Reviewed
• [Journal Article] Expression and regulation of cholesterol sulfotransferase(SULT2B1b) in human endometrium (2010)
  • Author(s): Koizumi M, Momoeda M, Hiroi H, Hosokawa Y, Tsutsumi R, Osuga Y, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 93 Pages: 1538-44
  • Peer Reviewed
• [Journal Article] Elevated serum soluble fms-like tyrosine kinase 1(sFlt1) level in women with hydatidiform mole (2010)
  • Author(s): Koga K, Osuga Y, Tajima T, Hirota Y, Igarashi T, Fujii T, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 94 Pages: 305-308
  • Peer Reviewed
• [Journal Article] Interleukin-4 induces expression of eotaxin in endometriotic stromal cells (2010)
  • Author(s): Ouyang Z, Osuga Y, Hirota Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y
  • Journal Title: Fertil Steril Fertil Steril Volume: 94 Pages: 58-62
  • Peer Reviewed
• [Journal Article] Autoamputated adnexa presents as a peritoneal loose body (2010)
  • Author(s): Koga K, Hiroi H, Osuga Y, Nagai M, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 93 Pages: 967-968
  • Peer Reviewed
• [Journal Article] Progesterone decreases bone morphogenetic protein(BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells (2010)
  • Author(s): Kodama A, Yoshino O, Osuga Y, Harada M, Hasegawa A, Hamasaki K, Takamura M, Koga K, Hirota Y, Hirata T, Takemura Y, Yano T, Taketani Y
  • Journal Title: Hum Reprod Volume: 25 Pages: 751-756
  • Peer Reviewed
• [Journal Article] Uterine artery pseudoaneurysm after cesarean section : case report and literature review (2010)
  • Author(s): Isono W., Tsutsumi R., Wada-Hiraike O., Fujimoto A., Osuga Y., Yano T., Taketani Y.
  • Journal Title: J Minim Invasive Gynecol Volume: 17 Pages: 687-691
  • Peer Reviewed
• [Journal Article] Uterine FK506-binding protein 52(FKBP52)-peroxiredoxin-6(PRDX6) signaling protects pregnancy from overt oxidative stress (2010)
  • Author(s): Hirota Y., Acar N., Tranguch S., Burnum K. E., Xie H., Kodama A., Osuga Y., Ustunel I., Friedman D. B., Caprioli R. M., Daikoku T., Dey S. K.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Pages: 15577-15582
  • Peer Reviewed
• [Journal Article] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells (2010)
  • Author(s): Hirata T., Osuga Y., Takamura M., Kodama A., Hirota Y., Koga K., Yoshino O., Harada M., Takemura Y., Yano T., Taketani Y.
  • Journal Title: Endocrinology Volume: 151 Pages: 5468-5476
  • Peer Reviewed
• [Journal Article] Hyaluronic acid reagent suppressed endometriotic lesion formation in a mouse model (2010)
  • Author(s): Hasegawa A., Yoshino O., Osuga Y., Kodama A., Takamura M., Nishii O., Taketani Y.
  • Journal Title: Fertil Steril Volume: 93 Pages: 2757-2759
  • Peer Reviewed
• [Journal Article] Case of chronic ectopic pregnancy diagnosed in which the complete shape of the fetus was visible by ultrasonography (2010)
  • Author(s): Harada M., Hiroi H., Fujiwara T., Fujimoto A., Kikuchi A., Osuga Y., Momoeda M., Kugu K., Yano T., Taketani Y.
  • Journal Title: J Obstet Gynaecol Res Volume: 36 Pages: 462-465
  • Peer Reviewed
• [Journal Article] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells (2010)
  • Author(s): Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, Yano T, Taketani Y
  • Journal Title: Endocrinology Volume: 151 Pages: 5468-76
  • Peer Reviewed
• [Journal Article] Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells. (2010)
  • Author(s): Kodama A, Yoshino O, Osuga Y, Harada M, Hasegawa A, Hamasaki K, Takamura M, Koga K, Hirota Y, Hirota T, Takemura Y, Yano T, Taketani Y
  • Journal Title: Hum Reprod Volume: 25 Pages: 751-6
  • Peer Reviewed
• [Journal Article] Aberrant implantation and growth of uterine leiomyoma in the abdominal wall after laparoscopically assisted myomectomy (2009)
  • Author(s): Wada-Hiraike O, Yamamoto N, Osuga Y, Yano T, Kozuma S, Taketani Y
  • Journal Title: Fertil Steril Volume: 92 Pages: 1747-1747
  • Peer Reviewed
• [Journal Article] Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision (2009)
  • Author(s): Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Hum Reprod Volume: 24 Pages: 3042-3048
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells (2009)
  • Author(s): Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Yano T, Nishii O, Taketani Y
  • Journal Title: Fertil Steril Volume: 92 Pages: 1794-1798
  • Peer Reviewed
• [Journal Article] Expression and possible implication of growth hormone-releasing hormone receptor splice variant 1 in endometriosis (2009)
  • Author(s): Fu L, Osuga Y, Yano T, Takemura Y, Morimoto C, Hirota Y, Schally AV, Taketani Y
  • Journal Title: Fertil Steril Volume: 92 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells. (2009)
  • Author(s): Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Yano T, Nishii O, Taketani Y.
  • Journal Title: Fertil Steril. Volume: 92 Pages: 1794-8
  • Peer Reviewed
• [Journal Article] Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision. (2009)
  • Author(s): Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y.
  • Journal Title: Hum Reprod Volume: 24 Pages: 3042-8
  • Peer Reviewed
• [Journal Article] Aberrant implantation and growth of uterine leiomyoma in the abdominal wall after laparoscopically assisted myomectomy. (2009)
  • Author(s): Wada-Hiraike O, Yamamoto N, Osuga Y, Yano T, Kozuma S, Taketani Y.
  • Journal Title: Fertil Steril Volume: 92 Pages: 1747-1747
  • Peer Reviewed
• [Journal Article] Expression and possible implication of growth hormone releasing hormone receptor splice variant 1 in endometriosis. (2009)
  • Author(s): Fu L, Osuga Y, Yano T, Takemura Y, Morimoto C, Hirota Y, Schally AV, Taketani Y.
  • Journal Title: Fertil Steril Volume: 92 Pages: 47-63
  • Peer Reviewed
• [Journal Article] Interleukin(IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8 (2009)
  • Author(s): Hirota Y, Osuga Y, Hasegawa A, Kodama A, Tajima T, Hamasaki K, Koga K, Yoshino O, Hirata T, Harada M, Takemura Y, Yano T, Tsutsumi O, Taketani Y
  • Journal Title: Endocrinology 150 Pages: 350-356
  • Peer Reviewed
• [Journal Article] Conjoined twins in a triplet pregnancy after intracytoplasmic sperm injection and blastocyst transfer : case report and review of the literature (2009)
  • Author(s): Hirata T, Osuga Y, Fujimoto A, Oishi H, Hiroi H, Fujiwara T, Yano T, Taketani Y
  • Journal Title: Fertil Steril 91 Pages: 933-933
  • Peer Reviewed
• [Journal Article] Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells (2009)
  • Author(s): Hasegawa A, Osuga Y, Hirota Y, Hamasaki K, Kodama A, Harada M, Tajima T, Takemura Y, Hirate T, Yoshino O, Koga K, Yano T, Taketani Y.
  • Journal Title: Hum Reprod 24 Pages: 408-414
  • Peer Reviewed
• [Journal Article] Interleukin-4 stimulates proliferation of endometriotic stromal cells (2008)
  • Author(s): OuYang Z, Hirota Y, Osuga Y, Hamasaki K, Hasegawa A, Tajima T, Hirata T, Koga K, Yoshino O, Harada M, Takemura Y, Nose E, Yano T, Taketani Y
  • Journal Title: Am J Pathol 173 Pages: 463-469
  • Peer Reviewed
• [Journal Article] Androgen insensitivity syndrome with serous gonadal cyst (2008)
  • Author(s): Yanai Y, Hiroi H, Osuga Y, Fujimoto A, Momoeda M, Yano T, Taketani Y.
  • Journal Title: Fertil Steril 90 Pages: 2018-2018
  • Peer Reviewed
• [Journal Article] Deficiency of immunophilin FKBP52 promotes endometriosis (2008)
  • Author(s): Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK.
  • Journal Title: Am J Pathol 173 Pages: 1747-1757
  • Peer Reviewed
• [Journal Article] Basic and translational research on proteinase-activated receptors : prateinase-activated receptors in female reproductive tissues and endometriosis (2008)
  • Author(s): Osuga Y, Hirota Y, Taketani Y.
  • Journal Title: J Pharmacol Sci 150 Pages: 422-425
  • Peer Reviewed
• [Presentation] 子宮内膜症の病態と治療 (2011)
  • Author(s): 大須賀穣
  • Organizer: 第16回日本生殖内分泌学会
  • Place of Presentation: 東京都
  • Year and Date: 2011-11-19
• [Presentation] 筋層内子宮筋腫(intramural myoma : IM)により誘導される子宮内膜の異常蠕動は妊娠率を低下させる (2011)
  • Author(s): 吉野修,浅田弘法,折坂誠,大須賀穣,土屋裕子,佐渡島陽子,古谷正敬,小辻文和,吉村泰典,西井修,武谷雄二
  • Organizer: 第63回産科婦人科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-08-29
• [Presentation] 子宮内膜のFKBP52-PRDX6経路が酸化ストレス防御に作用し妊娠成立に寄与する (2011)
  • Author(s): 広田泰,大須賀穣,上妻志郎,武谷雄二
  • Organizer: 第63回産科婦人科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-08-29
• [Presentation] 子宮内膜症進展におけるIL-17、GRO(Growth Related Oncogene)αを介したvicious cycleの形成 (2011)
  • Author(s): 高村将司,大須賀穣,泉玄太郎,齊藤亜子,長谷川亜希子,竹村由里,原田美由紀,平田哲也,広田泰,吉野修,甲賀かをり,武谷雄二
  • Organizer: 第63回産科婦人科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-08-29
• [Presentation] (2011)
  • Author(s): 泉玄太郎,甲賀かをり,大須賀穣,永井美和子,浦田陽子,高村将司,齊藤亜子,竹村由里,原田美由紀,吉野修,矢野哲,武谷雄二
  • Organizer: 第63回産科婦人科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-08-29
• [Presentation] 不妊症合併子宮内膜症療と再発予防 (2011)
  • Author(s): 大須賀穣
  • Organizer: 第51回日本産科婦人科内視鏡学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-08-05
• [Presentation] 鎌状赤血球症合併妊娠の一例 (2010)
  • Author(s): 大橋奈尾子,嘉本寛江,永松健,吉田志朗,兵藤博信,大知行,上妻志郎,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 水腎症をきたして発見された特異部位子宮内膜症の一例 (2010)
  • Author(s): 齊藤泉,磯野渉,土谷聡,甲賀かをり,川名敬,中川野哲,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 当科式腹腔鏡下手術の現況 (2010)
  • Author(s): 長坂貴顕,中江華子,藤本晃久,大須賀穣,矢野哲,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 当科における過去5年間の腹腔鏡下手術に伴う合併症の検討 (2010)
  • Author(s): 宮下真理子,原田美由紀,藤本晃久,大須賀穣,矢野哲,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 遠隔転移をきたした卵巣粘液性腺癌pT1a期の2例 (2010)
  • Author(s): 荒川敬一,松本陽子,有本貴英,土谷聡,織田克利,川名敬,百枝幹雄,矢野哲,上妻志郎,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 診断に苦盧した卵巣外子宮内膜症性嚢胞の2症例 (2010)
  • Author(s): 高橋千波,小泉美奈子,藤本晃久,中澤明里,中尾美木,大須賀穣,百枝幹雄,矢野哲,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] ハプトグロビン欠損症合併妊娠の分娩管理に対する考察 (2010)
  • Author(s): 松本玲央奈,保谷茉莉,梁井葉子,永松健,兵藤博信,大須賀穣,亀井良政,藤井知行,上妻志郎,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 妊娠後期に合失調症が増悪し,電気けいれん療法で改善を認め満期産に至った一例 (2010)
  • Author(s): 神尊貴裕,北麻里子,兵藤博信,小松篤史,吉田志朗,大須賀穣,亀井良政,藤井知之,上妻志朗,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 卵管采原発の卵管症の1例 (2010)
  • Author(s): 井上恵莉,土屋聡,織田克利,川名敬,中川俊介,大須賀穣,百枝幹雄,矢野哲,武谷雄二
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば市
  • Year and Date: 2010-11-28
• [Presentation] 子宮のp53欠損は早産を誘導する (2010)
  • Author(s): 広田泰, DeyS. K.,大須賀穣,上妻志郎,武谷雄二
  • Organizer: 第15回生殖内分泌学会
  • Place of Presentation: 豊中市
  • Year and Date: 2010-11-21
• [Presentation] The role of interleukin-17 in the pathogenesis of endometriosis (2010)
  • Author(s): Osuga Y
  • Organizer: 1^<st> Asian Conference on Endometriosis
  • Place of Presentation: Shanghai, China
  • Year and Date: 2010-10-16
• [Presentation] 鼠径部腫瘍を発症した真性半陰陽の一例 (2010)
  • Author(s): 鶴賀哲史,川名敬,有本貴英,土谷聡,中川俊介,大須賀穣,矢谷雄二
  • Organizer: 第119回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-13
• [Presentation] 術前断に苦慮した妊娠初期に脱落膜変化した子宮内膜症性卵巣嚢胞の1例 (2010)
  • Author(s): 宮坂亞希,川名敬,藤井知行,大須賀穣,中川俊介,上妻志郎,武谷雄二
  • Organizer: 第119回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-13
• [Presentation] ヒト卵巣におけるbonmorphogenetic proteins 2(BMP2)の役割に関する検討 (2010)
  • Author(s): 吉野修,大須賀穣,矢野哲,西井修,武谷雄二
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] 腹腔鏡下子宮内膜症性卵巣嚢胞摘出術後の再発率低下に低用量ピル(OC)は有益である (2010)
  • Author(s): 高村将司,甲賀かをり,泉玄太郎,児玉亜子,田島敏樹,長谷川亜里,原田美由紀,吉野修,大須賀穣,武谷雄二
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] TGFβは子宮内膜症細胞においてPAR2の発現ならびに機能を増強する (2010)
  • Author(s): 児玉亜子,大須賀穣,吉野修,泉玄太郎,高村将司,長谷川亜哲也,甲賀かをり,矢野哲,武谷雄二
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] 子宮腺筋症に対するDienogestの効果 (2010)
  • Author(s): 泉玄太郎,平田哲也,甲賀かをり,大須賀穣,高村将司,小倉さやか,児玉亜北麻里子,竹村由里,森本千恵子,矢野哲,武谷雄二
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] 子宮内膜ポリープに対する黄体・卵胞ホルモン混合製剤の効果についての検討 (2010)
  • Author(s): 平池修,大須賀穣,竹村由里,小泉美奈子,甲賀かをり,山正統,百枝幹雄,久具宏司,矢野哲,武谷雄二
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] レボノルゲストレル(LNG)単独投与による緊急避妊の作用機序の検討 (2010)
  • Author(s): 矢野直美,大須賀穣,矢野哲,藤本晃久,北村邦夫,武谷雄二
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-24
• [Presentation] Immune and Inflammatory Aspects of Endometriosis : the implication of T cells in endometriosis (2010)
  • Author(s): Yutaka Osuga
  • Organizer: 14th World Congress of Gynecological Endocrinology
  • Place of Presentation: Firenze, Italy
  • Year and Date: 2010-03-04
• [Presentation] TGFβは子宮内膜症細胞においてPAR2の発現・機能を促進する (2009)
  • Author(s): 児玉亜子,大須賀穣,吉野修,泉玄太郎高村将司,長谷川亜希子,竹村由里,原田美由紀,平田哲也,広田泰,甲賀かをり,矢野哲,武谷雄二
  • Organizer: 第14回生殖内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-28
• [Presentation] ART妊娠と一般不妊妊娠の周産期予後の検討 (2009)
  • Author(s): 堤亮,藤本晃久,竹村由里,小泉美奈子,渡辺裕子,大井なぎさ,田中慧,張士青,廣井久彦,大須賀穣,矢野哲,武谷雄二
  • Organizer: 第54回日本生殖医学会
  • Place of Presentation: 金沢
  • Year and Date: 2009-11-22
• [Presentation] 低用量ピルは腹腔鏡下子宮内膜症性卵巣嚢胞摘出術の術後再発を低下させる (2009)
  • Author(s): 崎かほり,田島敏樹,長谷川亜希子,竹村由里,原田美由紀,森本千恵子,平田哲也,廣田泰,吉野修,大須賀穣,武谷雄二
  • Organizer: 第54回日本生殖医学会
  • Place of Presentation: 金沢
  • Year and Date: 2009-11-22
• [Presentation] 婦人科がんの妊孕性温存治療子宮内膜症の妊孕性温存治療 (2009)
  • Author(s): 大須賀穣
  • Organizer: 第54回日本生殖医学会
  • Place of Presentation: 金沢
  • Year and Date: 2009-11-22
• [Presentation] Planned treatment delayにより生児を得た子宮頸部浸潤癌合併妊娠の一例 (2009)
  • Author(s): 鶴賀哲敬,中川俊介,大須賀穣,矢野哲,上妻志郎,武谷雄二
  • Organizer: 第118回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: さいたま市
  • Year and Date: 2009-11-08
• [Presentation] 子宮動脈バルーン留置併用子宮全摘術にて治療し得た子宮動静脈奇形の一例 (2009)
  • Author(s): 山本直子,甲賀かをり,藤本晃久,丸山正統,稲生信一,赤羽正章,大須賀穣,矢野哲,武谷雄二
  • Organizer: 第118回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: さいたま市
  • Year and Date: 2009-11-08
• [Presentation] 卵巣癌明細胞腺癌I・II期の予後因子の検討子宮内膜症との関連から (2009)
  • Author(s): 鶴英,土谷聡,清木孝之,中川俊介,八杉利治,大須賀穣,矢野哲,上妻志郎,武谷雄二
  • Organizer: 第47回日本癌治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-22
• [Presentation] 診断的腹腔鏡検査で左付属器欠損と腹腔内遊離体を発見した一例 (2009)
  • Author(s): 永井美和子,甲賀かをり,平田哲也,平池修,藤本晃久,廣井久彦,大須賀穣,矢野哲,上妻志郎,武谷雄二,福嶋敬宜
  • Organizer: 第117回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-14
• [Presentation] Pseudo-Meigs症候群を合併した骨盤内腫瘍の2例 (2009)
  • Author(s): 森住佑本貴英,砂川空広,川名敬,織田克利,中川俊介,大須賀穣,矢野哲,上妻志郎,武谷雄二
  • Organizer: 第117回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-14
• [Presentation] 子宮内膜症間質細胞(ESC)におけるIL-17Fの作用について (2009)
  • Author(s): 平田哲也,大須賀穣,高村将司,児玉亜子,甲賀か村由里,長谷川亜希子,田島敏樹,矢野哲,武谷雄二
  • Organizer: 第61回日本産科婦人科学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-03
• [Presentation] Tunicamycin(TM)は子宮内膜症間質細胞におけるTRAIL誘導性アポトーシスを特異的に増強する (2009)
  • Author(s): 長谷川亜希子,大須賀穣,広田泰,濱崎かほり,児玉亜子,原田美由紀,竹村由里,平田哲也,森本千恵子,吉野修,矢野哲,武谷雄二
  • Organizer: 第61回日本産科婦人科学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-03
• [Presentation] ヒト子宮内膜におけるBMP-7の発現および機能に関する検討 (2009)
  • Author(s): 児玉亜子,大須賀穣,吉野修,長谷川亜希子,高村将司,原田美由紀,平田濱崎かほり,矢野哲,武谷雄二
  • Organizer: 第61回日本産科婦人科学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-03
• [Presentation] ヒアルロン酸の子宮内膜症への治療効果に関する基礎的検討 (2009)
  • Author(s): 吉野修,長谷川亜希子,大須賀穣,武谷雄二,西井修
  • Organizer: 第61回日本産科婦人科学会
  • Year and Date: 2009-04-03
• [Presentation] Progress in the management of endometriosis (2008)
  • Author(s): Osuga Y
  • Organizer: 94^<th> Annual Meeting of the Korean Society of Obstetrics and Gynecology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-09-27
• [Presentation] Current understanding of the pathogenesis of endometriosis (2008)
  • Author(s): Osuga Y
  • Organizer: 13^<th> Seoul International Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-09-25
• [Presentation] 体外受精後にPIDを発症した2症例
  • Author(s): 小泉美奈子,廣井久彦,藤本晃久,清木孝之,大井なぎさ,大須賀穣,百枝幹雄,矢野哲,武谷雄二
  • Organizer: 第54回日本生殖医学会
  • Place of Presentation: 金沢
• [Presentation] ART妊娠における前置胎盤のリスクについての検討
  • Author(s): 竹村由里,藤本晃久,堤亮,大井なぎさ,小泉美奈子,大須賀穣,矢野哲,武谷雄二
  • Organizer: 第54回日本生殖医学会
  • Place of Presentation: 金沢