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A novel treatment strategy for gastrointestinal development of extremely low birth weight infants : Administration of micelles derived from pulmonary surfactants in a pregnant rabbit model

Research Project

Project/Area Number 20591909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Fukui

Principal Investigator

NISHIJIMA Koji  University of Fukui, 医学部, 助教 (80334837)

Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Jin  福井大学, 医学部附属病院, 助教 (20467129)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肺サーファクタント / 胎脂 / ミセル / 消化管成熟 / 壊死性腸炎 / 超低出生体重児
Research Abstract

We have shown the presence of micelles derived from pulmonary surfactant in human full-term amniotic nuid. Micellization is also an important step in postnatal lipid absorption because fat is insoluble in the aqueous environment of the small intestinal lumen. Micelles exist in both amniotic fluid swallowed by the fetus and human breast milk ingested by neonates. Our study aimed to develop a new treatment strategy for gastrointestinal development of extremely low birth weight infants with a focus on the presence of micelles in the environment of fetus and neonates. We previously showed that continuous administration of micelles derived from pulmonary surfactants and vernix caseosa enhanced the development of the small intestine of the rabbit fetus.
In our study, we used fluorescently labeled liposomes to show that micelles derived from pulmonary surfactant and vernix caseosa complex might directly and locally contribute to gastrointestinal development of the fetus. In addition, we developed a neonatal rat model to determine the potential beneficial effects of these micelles against necrotizing enterocolitis. Although further studies are required, our findings provide greater understanding of the physiologic interactions between the pulmonary, dermal-epidermal, and gastrointestinal development. One of the most critical issues in the early development of premature infants is the prevention and treatment of necrotizing enterocolitis. We expect that our study may contribute in improving the prognosis of premature infants.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 新生児壊死性腸炎に対する新たな治療戦略:肺サーファクタントを用いた動物実験2010

    • Author(s)
      西島浩二、三浦潤一郎、高橋仁、塚原宏一、小辻文和
    • Journal Title

      福井大学重点研究成果集

      Pages: 126-127

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新生児壊死性腸炎に対する新たな治療戦略:肺サーファクタントを用いた動物実験2010

    • Author(s)
      西島浩二
    • Journal Title

      福井大学重点研究成果集2010-明日への挑戦-

      Pages: 126-127

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 超低出生体重児の消化管成熟に向けた治療戦略:肺サーファクタントを用いた動物実験2009

    • Author(s)
      西島浩二、三浦潤一郎、高橋仁、塚原宏一、小辻文和
    • Journal Title

      福井大学重点研究成果集

      Pages: 66-67

    • NAID

      10023969156

    • Related Report
      2010 Final Research Report
  • [Journal Article] 超低出生体重児の消化管成熟に向けた治療戦略:肺サーファクタントを用いた動物実験2009

    • Author(s)
      西島浩二
    • Journal Title

      福井大学重点研究成果集2009-明日への挑戦-

      Pages: 66-67

    • NAID

      10023969156

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood.2008

    • Author(s)
      Tsukahara H, Ohta N, Tokuriki S, Nishijima K, Kotsuji F, Kawakami H, Ohta N, Sekine K, Nagasaka H, Mayumi M.
    • Journal Title

      Metabolism 57

      Pages: 215-220

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 超低出生体重児の消化管成熟に向けた治療戦略:肺サーファクタントを用いた動物実験2008

    • Author(s)
      西島浩二、宿南憲一、高橋仁、塚原宏一、小辻文和
    • Journal Title

      日本周産期・新生児医学会雑誌 44

      Pages: 978-981

    • NAID

      10023969156

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 超低出生体重児の消化管成熟に向けた治療戦略 : 肺サーフアクタントを用いた動物実験2008

    • Author(s)
      西島浩二, 他
    • Journal Title

      日本周産期・新生児医学会雑誌 44

      Pages: 978-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超低出生体重児の消化管成熟に向けた治療戦略:肺サーファクタントを用いた動物実験2008

    • Author(s)
      西島浩二、宿南憲一、高橋仁、塚原宏一、小辻文和
    • Organizer
      第44回日本周産期・新生児医学会学術集会ワークショップ
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 超低出生体重児の消化管成熟に向けた治療戦略 : 肺サーフアクタントを用いた動物実験2008

    • Author(s)
      西島浩二, 他
    • Organizer
      第44回日本周産期・新生児医学会学術集会ワークショップ2
    • Place of Presentation
      横浜市パシフイコ横浜
    • Year and Date
      2008-07-14
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 腸管機能亢進剤とこれを用いた壊死性腸炎の治療または予防方法2009

    • Inventor(s)
      西島浩二、小辻文和、宿南憲一
    • Industrial Property Rights Holder
      国立大学法人福井大学
    • Acquisition Date
      2009-08-19
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 腸管機能亢進剤とこれを用いた壊死性腸炎の防止方法2009

    • Inventor(s)
      西島浩二, 小辻文和, 宿南憲一
    • Industrial Property Rights Holder
      福井大学
    • Filing Date
      2009-10-02
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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