Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage

• Project/Area Number: 20591913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: TANIGUCHI Yukiko Osaka University, 医学系研究科, 助教 (60423175)
• Co-Investigator(Kenkyū-buntansha): TOMIMATSU Takuji 大阪大学, 大学院・医学系研究科, 助教 (30346209) ; KANAGAWA Takeshi 大阪大学, 大学院・医学系研究科, 助教 (40346218) ; MIMURA Kazuya 大阪大学, 医学系研究科, 助教 (50437422)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 低酸素性虚血性脳症 / CRP / 未熟ラット / 低酸素性虚血性脳障害 / 新生児

Research Abstract

In utero exposure to infection or inflammation is a strong and independent predictor of cerebral palsy. Using a rat model of neonatal hypoxic-ischemic encephalopathy, we investigated the hypothesis that C-reactive protein (CRP), which is not specific for infection, aggrabates vulnerability of the immature brain to HI.

Research Products

• [Journal Article] Impaired delivery outcomes in pregnancies following myomectomy compared to myoma-complicated pregnancies. (2011)
  • Author(s): Kinugasa-Taniguchi Y, Ueda Y, Hara-Oyagi C, Enomoto T, Kanagawa T, Kimura T.
  • Journal Title: J Reprod Med 56 Pages: 142-8
  • Peer Reviewed
• [Journal Article] Ceftriaxone preconditioning confers neuroprotection in neonatal rats through glutamate transporter 1 upregulation. (2011)
  • Author(s): Mimura K, Tomimatsu T, Minato K, Taniguchi Y, Kanagawa T, Nozaki M, Yanagihara I, Kimura T
  • Journal Title: Reprod Sci in press
  • Peer Reviewed
• [Journal Article] Current status of negative treatment decision-making for fetuses with a prenatal diagnosis of neonatal surgical disease at a single Japanese institution. (2010)
  • Author(s): Usui N, Kanagawa T, Kamiyama M, Tani G, Kinugasa-Taniguchi Y, Kimura T, Fukuzawa M.
  • Journal Title: J Pediatr Surg 45 Pages: 2328-33
  • Peer Reviewed
• [Journal Article] Maternal blood serum and plasma human tumor- associated antigen RCAS1 during the course of uncomplicated pregnancies : a prospective study. (2010)
  • Author(s): Tskitishvili E, Sharentuya N, Tsubouchi H, Kinugasa-Taniguchi Y, Kanagawa T, Shimoya K, Tomimatsu T, Kimura T.
  • Journal Title: Am J Reprod Immunol 64 Pages: 218-24
  • Peer Reviewed
• [Journal Article] Nicotine suppresses interleukin-6 production from vascular endothelial cells : a possible therapeutic role of nicotine for preeclampsia (2010)
  • Author(s): Sharentuya N, Tomimatsu T, Mimura K, Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T.
  • Journal Title: Reprod Sci 17 Pages: 556-63
  • Peer Reviewed
• [Journal Article] Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in in vitro model of preeclamptic vascular endothelium : apossible therapeutic role of nicotinic acetylcholine receptor (nAChR) agoonists for preeclampsia. (2010)
  • Author(s): Mimura K, Tomimatsu T, Sharentuya N, Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T.
  • Journal Title: Am J Obstet Gynecol 202
  • Peer Reviewed
• [Journal Article] Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage ; a preliminary study (2010)
  • Author(s): Kinugasa-Taniguchi Y, Tomimatsu T, Mimura K, Kanagawa T, Shimoya K, Murata Y, Kimura T
  • Journal Title: Reprod Sci 17 Pages: 419-25
  • Peer Reviewed
• [Journal Article] 出生前に消極的治療方針が選択された新生児外科症例の検討 (2010)
  • Author(s): 臼井規朗, 金川武司, 上山雅史, 谷岳人, 谷口(衣笠)友基子, 木村正, 福澤正洋
  • Journal Title: 日本周産期・新生児医学会誌 46 Pages: 32-8
  • NAID: 10026414098
  • Peer Reviewed
• [Journal Article] Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial (2010)
  • Author(s): Tskitishvili E, Sharentuya N, Temma-Asano K, Mimura K, Kinugasa-Taniguchi Y, Kanagawa T, Fukuda H, Kimura T, Tomimatsu T, Shimoya K
  • Journal Title: cells Mol Hum Reprod 33 Pages: 188-99
  • Peer Reviewed
• [Journal Article] Temporal and spatial expression of tumor-associated antigen RCAS1 in pregnant mouse uterus. (2010)
  • Author(s): Tskitishvili E, Nakamura H, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T, Tomimatsu T, Shimoya K.
  • Journal Title: Am J Reprod Immunol 63 Pages: 137-43
  • Peer Reviewed
• [Journal Article] Impaired delivery outcomes in pregnancies following myomectomy compared to myoma-complicated pregnancies. (2010)
  • Author(s): Kinugasa-Taniguchi Y
  • Journal Title: J Reprod Med Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] 出生前に消極的治療方針が選択された新生児外科症例の検討 (2010)
  • Author(s): 臼井規朗、谷口(衣笠)友基子
  • Journal Title: 日本周産期・新生児医学会誌 Volume: 46 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in in vitro model of preeclamptic vascular endothelium : apossible therapeutic role of nicotinic acetylcholine receptor (nAChR) agoonists for preeclampsia. (2010)
  • Author(s): Mimura K, Kinugasa-Taniguchi Y
  • Journal Title: Am J Obstet Gynecol Volume: 202
  • Peer Reviewed
• [Journal Article] Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage ; a preliminary study. (2010)
  • Author(s): Kinugasa-Taniguchi Y
  • Journal Title: Reprod Sci Volume: 17 Pages: 419-425
  • Peer Reviewed
• [Journal Article] Nicotine suppresses interleukin-6 production from vascular endothelial cells : a possible therapeutic role of nicotine for preeclampsia. (2010)
  • Author(s): Sharentuya N, Kinugasa-Taniguchi Y
  • Journal Title: Reprod Sci Volume: 17 Pages: 556-563
  • Peer Reviewed
• [Journal Article] Current status of negative treatment decision-making for fetuses with a prenatal diagnosis of neonatal surgical disease at a single Japanese institution. (2010)
  • Author(s): Usui N, Kinugasa-Taniguchi Y
  • Journal Title: J Pediatr Surg Volume: 45 Pages: 2328-2333
  • Peer Reviewed
• [Journal Article] Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage ; a preliminary study (2010)
  • Author(s): Kinugasa-Taniguchi Y, et al.
  • Journal Title: Reprod Sci
  • Peer Reviewed
• [Journal Article] 本学におけるActive Management of Labor. (2009)
  • Author(s): 荻田和秀, 冨松拓治, 澤田健二郎, 上田豊, 金川武司, 衣笠友基子, 坂田正博, 木村正
  • Journal Title: 産婦人科の進歩 61 Pages: 101-3
  • NAID: 130000137673
  • Peer Reviewed
• [Journal Article] Amniotic fluid 'sludge' detected in patients with subchorionic hematoma : a report of two cases. (2009)
  • Author(s): Tskitishvili E, Tomimatsu T, Kanagawa T, Sawada K, Kinugasa Y, Mimura K, Kimura T.
  • Journal Title: Ultrasound Obstet Gynecol 33 Pages: 484-6
  • Peer Reviewed
• [Journal Article] 乳汁分泌とホルモン (2009)
  • Author(s): 谷口(衣笠)友基子, 木村正
  • Journal Title: 産婦人科治療 99 Pages: 325-31
  • Peer Reviewed
• [Presentation] 妊娠後期に脳出血を発症し初めてもやもや病の診断がついた妊婦が、同一妊娠期間中に再出血をきたし死亡した1例 (2009)
  • Author(s): 三宅達也, 冨松拓治, 谷口友基子, 香山晋輔, 磯部晶, 金川武司, 澤田健二郎, 木村正, 中村元, 吉矢和久, 荻田和秀
  • Organizer: 第121回近畿産科婦人科学会
  • Place of Presentation: 神戸国際会議場,兵庫
  • Year and Date: 2009-11-01
• [Presentation] 抗Jra抗体陽性の血液型不適合妊娠において新生児貧血を認めた1例 (2009)
  • Author(s): 佐々本尚子, 冨松拓治, 香山晋輔, 谷口友基子, 磯部晶, 金川武司, 澤田健二郎, 木村正
  • Organizer: 第121回近畿産科婦人科学会
  • Place of Presentation: 神戸国際会議場,兵庫
  • Year and Date: 2009-11-01
• [Presentation] β-ラクタム抗生剤でのプレコンディショニングによる新生児脳障害予防の可能性 (2009)
  • Author(s): 味村和哉, 冨松拓治, 谷口友基子, 金川武司, 木村正
  • Organizer: 第45回日本周産期・新生児医学会
  • Place of Presentation: 名古屋国際会議場,愛知
• [Presentation] 当科における前置胎盤の手術成績と大量出血に対する止血法の比較検討 (2009)
  • Author(s): 石井貴子, 澤田健二郎, 衣笠友基子, 香山晋輔, 磯部晶, 金川武司, 富松拓治, 荻田和秀, 木村正
  • Organizer: 第120回近畿産科婦人科学会
  • Place of Presentation: 神戸国際会議場,大阪
• [Presentation] ニコチンは妊娠高血圧症候群の治療薬となりうるか? -基礎的検討- (2009)
  • Author(s): 沙仁吐雅, 手島昭樹, 味村和哉, 金川武司, 衣笠友基子, ツキティシヴィリ・エカテリネ, 木村正
  • Organizer: 第61回日本産科婦人科学会
  • Place of Presentation: 国立京都国際会館,京都
• [Presentation] 分娩第二期遷延後の帝王切開分娩後、次回妊娠時に頸管無力症となった2症例 (2009)
  • Author(s): 香山晋輔, 冨松拓治, 澤田健二郎, 金川武司, 磯部晶, 衣笠友基子, 木村正
  • Organizer: 第61回日本産科婦人科学会
  • Place of Presentation: 国立京都国際会館,京都
• [Presentation] 当科で経験した心筋症合併妊娠の治療経験 (2009)
  • Author(s): 大八木知史, 若林敦子, 澤田健二郎, 衣笠友基子, 金川武司, 冨松拓治, 荻田和秀, 坂田正博, 木村正
  • Organizer: 第61回日本産科婦人科学会
  • Place of Presentation: 国立京都国際会館,京都
• [Presentation] Possible connection between sEndoglin and S100B protein might lead to the development of endothelial disfunction and preeclampsia. (2009)
  • Author(s): Tskitishvili E, Sharentuya N, Temma-Asano K, Tomimatsu T, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T, Shimoya K.
  • Organizer: 第3回世界産婦人科研究機構サミット
  • Place of Presentation: 仙台国際センター,宮城
• [Presentation] Nicotine suppresses interleukin-6 production from vascular endothelial cells. (2009)
  • Author(s): Tomimatsu T, Syarentuya N, Mimura K, Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T.
  • Organizer: 第3回世界産婦人科研究機構サミット
  • Place of Presentation: 仙台国際センター,宮城
• [Presentation] 当科で経験した周産期心筋症(Peripartum cardiomyopathy : PPM)の2症例 (2008)
  • Author(s): 若林敦子, 大八木知史, 澤田健二郎, 衣笠友基子, 香山晋輔, 上田豊, 金川武司, 冨松拓治, 坂田正博, 木村正
  • Organizer: 第119回近畿産婦人科学会
  • Place of Presentation: 千里ライフサイエンスセンター,大阪
  • Year and Date: 2008-11-09
• [Presentation] 当院における出生前診断の適応と帰結 (2008)
  • Author(s): 衣笠友基子, 味村和哉, 香山晋輔, 上田豊, 金川武司, 澤田健二郎, 冨松拓治, 木村正
  • Organizer: 第119回近畿産婦人科学会
  • Place of Presentation: 千里ライフサイエンスセンター,大阪
  • Year and Date: 2008-11-09
• [Presentation] 前置胎盤合併に対して、子宮内胎児死亡誘導後に中期中絶術を施行した2症例 (2008)
  • Author(s): 金川武司, 味村和哉, 香山晋輔, 衣笠友基子, 上田豊, 澤田健二郎, 冨松拓治, 坂田正博, 木村正
  • Organizer: 第119回近畿産婦人科学会
  • Place of Presentation: 千里ライフサイエンスセンター,大阪
  • Year and Date: 2008-11-09
• [Presentation] 産褥期大量出血に対する子宮タンポナーデの有効性の検討Sengtaken-Blakemore tube(SB tube)を用いて (2008)
  • Author(s): 石井貴子, 澤田健二郎, 衣笠友基子, 香山晋輔, 金川武司, 上田豊, 冨松拓治, 荻田和秀, 坂田正博, 木村正
  • Organizer: 第119回近畿産婦人科学会
  • Place of Presentation: 千里ライフサイエンスセンター,大阪
  • Year and Date: 2008-11-09
• [Presentation] 出生前超音波検査で認めた四肢短縮例における鼻骨長計測の有用性 (2008)
  • Author(s): 金川武司, 冨松拓治, 衣笠友基子, 味村和哉, 木村正
  • Organizer: 第48回日本先天異常学会学術会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-29
• [Presentation] 湿布の大量貼付によって引き起こされたと思われる胎児動脈管早期収縮の一例 (2008)
  • Author(s): 金川武司, 冨松拓治, 衣笠友基子, 荻田和秀, 荒堀仁美, 小垣滋豊, 和田和子, 木村正
  • Organizer: 第10回大阪新生児研究
  • Place of Presentation: 大阪薬業年金会館,大阪
  • Year and Date: 2008-06-07
• [Presentation] CRPが新生児低酸素性虚血性脳障害を増悪させる (2008)
  • Author(s): 衣笠友基子 味村和哉 金川武司冨松拓治 下屋浩一郎 木村正
  • Organizer: 日本産婦人科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-12
• [Presentation] ニコチンの妊娠高血圧症候群治療薬としての可能性～HUVECと抗血管新生因子を用いた妊娠高血圧症候群モデルを用いて～ (2008)
  • Author(s): 味村和哉, 冨松拓治, 沙仁吐雅, 衣笠友基子, 金川武司, 木村正
  • Organizer: 第29回日本妊娠高血圧学会
  • Place of Presentation: 福島ビューホテル,福島
• [Presentation] 湿布の大量貼付によって引き起こされたと思われる胎児動脈管早期収縮の一例 (2008)
  • Author(s): 金川武司, 冨松拓治, 衣笠友基子, 荻田和秀, 荒堀仁美, 小垣滋豊, 和田和子, 木村正
  • Organizer: 第44回日本周産期・新生児医学会
  • Place of Presentation: パシフィコ横浜,神奈川
• [Presentation] 本学におけるActive Management of Labor. (2008)
  • Author(s): 荻田和秀, 冨松拓治, 澤田健二郎, 上田豊, 金川武司, 衣笠友基子, 坂田正博, 木村正
  • Organizer: 第118回近畿産科婦人科学会
  • Place of Presentation: 守口ロイヤルパインズホテル,大阪