| Project/Area Number |
20591914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
KANAGAWA Takeshi Osaka University, 大学院・医学系研究科, 助教 (40346218)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIMATSU Takuji 大阪大学, 大学院・医学系研究科, 助教 (30346209)
TANIGUCHI Yukiko 大阪大学, 大学院・医学系研究科, 助教 (60423175)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 新生児低酸素虚血性脳障害 / 胎児付属物 / 幹細胞 / CRP / β-ラクタム抗生剤 / プレコンディショニング / 臍帯血管内皮細胞 / 新生児脳障害 / 可溶性fms様チロシンキナーゼ(sFltl) / 可溶性エンドグリン(sEng) / NF-κB / STIC法 |
|---|
| Research Abstract |
The Perinatal brain damage due to the fetal distress or neonatal distress remains the most important problem although the perinatal care develops rapidly remarkably.
The aims of this research are the decrease the perinatal damage. In this research, we discovered that C-Reactive protein makes the immature brain susceptible to Hypoxic ischemic insult, even if the insult causes little or no injury by itself. We also clarified that the preconditioning by the beta-lactam antibiosis protects the immature brain damage.
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