| Project/Area Number |
20591925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUGIURA Mayumi Nagoya City University, 大学院・医学研究科, 教授 (30264740)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Yasuhiko 名古屋市立大学, 大学院・医学研究科, 准教授 (50254280)
SUZUMORI Nobuhiro 名古屋市立大学, 大学院・医学研究科, 准教授 (70326148)
MIYOSHI Ichiro 名古屋市立大学, 大学院・医学研究科, 教授 (10183972)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 習慣流産 / 不育症 / LIF / SYCP3 / Leukemia Inhibitory Factor / GFPマウス / 骨髄移植 / 子宮内膜幹細胞 |
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| Research Abstract |
Leukaemia inhibitory factor (LIF) was found to exist in the decidua tissue by Western blot. There was no difference of the concentration of LIF between the aborted and artificial aborted decidua and also no difference of the concentration of LIF derived from cervical fluid at 4-5 weeks gestation between subsequent live birth and miscarriage groups. However, the concentration in chemical pregnancy and miscarriage with normal embryonic karyotype tended to be higher than that with abnormal embryonic karyotype.
SYCP3 mutation was found in one of 101 patients and one of 82 fertile women and may not be associated with recurrent miscarriage caused by aneuploidy.
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