| Project/Area Number |
20591926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUZUKI Yoshikatsu Nagoya City University, 大学院・医学研究科, 研究員 (30254288)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tamao 名古屋市立大学, 大学院・医学研究科, 研究員 (20405210)
ITOH Takeo 名古屋市立大学, 大学院・医学研究科, 教授 (70159888)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 妊娠高血圧症候群 / 血管内皮機能 / L-アルギニン / 葉酸 / 発症予知 / 予防 / 血管内皮障害 / 血管内皮 |
|---|
| Research Abstract |
Preeclampsia causes to increase vascular tone and permeability due to the activation of endothelial function. In the present study, we investigated whether an oral supplementation of L-arginine plus folic acid could improve it and prevent from developing preeclampsia. The concentration of L-arginine in RBC had been increasing in normal pregnant women, while it was reduced in preeclamptic women. Flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in high risk women at early pregnancy. The reduction could be improved by the contentious administration of L-arginine 1g plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might improve the endothelial dysfunction seen in high risk group and prevent onset of preeclampsia.
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