Investigate the new serum markers and create clinical guidelines for the diagnosis of amniotic fluid embolism
| Project/Area Number |
20591927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nara Medical University |
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Principal Investigator |
OI Hidekazu Nara Medical University, 医学部, 准教授 (10283368)
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| Co-Investigator(Kenkyū-buntansha) |
HIROSHI Kobayashi 奈良県立医科大学, 医学部, 教授 (40178330)
TAKETOSHI Noguchi 奈良県立医科大学, 医学部, 助教 (10464661)
坂田 麻理子 奈良県立医科大学, 医学部, 助教 (00445058)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 産科学 / 血清診断マーカー / Sialyl Tn / 統計 / 致死的因子 / 予後スコア / 羊水塞栓症 / 血清マーカー / 羊水特異マーカー / 低分子STN / 簡易測定キット / 診断基準 |
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| Research Abstract |
The new serum marker would be identify from the protein specially or exclusively present in amniotic fluid by proteomic analysis. The method for detecting circulating levels of the new marker which is high ratio of amnion/serum level may be a sensitive method for diagnosis of AFE. One hundred and thirty-five patients met the criteria of AFE, which included fatal (n=65) and non-fatal AFE (n=70). Maternal full term gestational weeks, multiparous, non-cesarean sections, Sialyl Tn (STN) levels, IL-8 levels, cardiac arrest, dyspnea and loss of consciousness were the risk factors for death found in this study using by chi-square analysis(p<0.01).In regard to each case, an increase in the proportion of lethal factor will also lead to the increase of mortality. It would be adequate for creating the prognostic score of AFE.
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Report
(4 results)
Research Products
(19 results)
