• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigate the new serum markers and create clinical guidelines for the diagnosis of amniotic fluid embolism

Research Project

Project/Area Number 20591927
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

OI Hidekazu  Nara Medical University, 医学部, 准教授 (10283368)

Co-Investigator(Kenkyū-buntansha) HIROSHI Kobayashi  奈良県立医科大学, 医学部, 教授 (40178330)
TAKETOSHI Noguchi  奈良県立医科大学, 医学部, 助教 (10464661)
坂田 麻理子  奈良県立医科大学, 医学部, 助教 (00445058)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords産科学 / 血清診断マーカー / Sialyl Tn / 統計 / 致死的因子 / 予後スコア / 羊水塞栓症 / 血清マーカー / 羊水特異マーカー / 低分子STN / 簡易測定キット / 診断基準
Research Abstract

The new serum marker would be identify from the protein specially or exclusively present in amniotic fluid by proteomic analysis. The method for detecting circulating levels of the new marker which is high ratio of amnion/serum level may be a sensitive method for diagnosis of AFE. One hundred and thirty-five patients met the criteria of AFE, which included fatal (n=65) and non-fatal AFE (n=70). Maternal full term gestational weeks, multiparous, non-cesarean sections, Sialyl Tn (STN) levels, IL-8 levels, cardiac arrest, dyspnea and loss of consciousness were the risk factors for death found in this study using by chi-square analysis(p<0.01).In regard to each case, an increase in the proportion of lethal factor will also lead to the increase of mortality. It would be adequate for creating the prognostic score of AFE.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] 帝王切開術中に呼吸困難をきたし母体血清亜鉛コプロポルフィリン1の著名高値を示した1例2010

    • Author(s)
      河元洋、大井豪一(10番目)、小林浩(11番目)
    • Journal Title

      周産期医学 40

      Pages: 1681-1684

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fatal factors of clinical manifestations and laboratory testing in patients with amniotic fluid embolism.2010

    • Author(s)
      大井豪一, 野口武俊(3番目), 小林浩(8番目)
    • Journal Title

      Gynecol Obstet Invest 70(2)

      Pages: 138-144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatal factors of clinical manifestations and laboratory testing in patients with amniotic fluid embolism.2010

    • Author(s)
      Oi H.
    • Journal Title

      Gynecol Obstet Invest.

      Volume: 70(2) Pages: 1245-1254

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 症状別解析からみた羊水塞栓症の致死的因子2009

    • Author(s)
      大井豪一、野口武俊(5番目)、小林浩(8番目)
    • Journal Title

      日本産婦人科・新生児血液学会誌 19(1)

      Pages: 21-22

    • NAID

      10026710122

    • Related Report
      2010 Final Research Report
  • [Journal Article] 症状別解析からみた羊水塞栓症の致死的因子2009

    • Author(s)
      大井豪一
    • Journal Title

      日本産婦人科・新生児血液学会誌 19

      Pages: 21-22

    • NAID

      10026710122

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 会員質問コーナーQ&A 羊水塞栓症の診断に関して2008

    • Author(s)
      大井豪一
    • Journal Title

      産婦人科の進歩 60(3)

      Pages: 301-301

    • Related Report
      2010 Final Research Report
  • [Journal Article] Iron-dependent oxidative stress as a pathogenesis for preterm birth2008

    • Author(s)
      坂田 麻理子
    • Journal Title

      Obstet Gynecol Surv. 63(10)

      Pages: 651-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 会員質問コーナーQ&A羊水塞栓症の診断に関して2008

    • Author(s)
      大井 豪一
    • Journal Title

      産婦人科の進歩 60(3)

      Pages: 301-301

    • Related Report
      2008 Annual Research Report
  • [Presentation] 羊水塞栓症における血清Sialyl Tn値の意義に関して2010

    • Author(s)
      大井豪一
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 羊水塞栓症における血清Sialyl Tn値の意義に関する検討2010

    • Author(s)
      大井豪一
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 症状別解析からみた羊水塞栓症の致死的因子2009

    • Author(s)
      大井豪一
    • Organizer
      日本産婦人科・新生児血液学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-12
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 致死的羊水塞栓症における危険因子の解明2009

    • Author(s)
      大井豪一
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-03
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 妊婦さんが目の前で羊水塞栓症を発症したら 最善の対処法に関して2008

    • Author(s)
      大井豪一
    • Organizer
      第6回三河地区学術研修会
    • Place of Presentation
      岡崎
    • Year and Date
      2008-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊婦さんが目の前で羊水塞栓症を発症したら最善の対処方法に関して2008

    • Author(s)
      大井 豪一
    • Organizer
      第6回三河地区学術研修会
    • Place of Presentation
      岡崎市
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Book] 産婦人科研修ハンドブック 羊水塞栓症2010

    • Author(s)
      大井豪一
    • Publisher
      海馬書房
    • Related Report
      2010 Final Research Report
  • [Book] 医療の最先端-奈良医大からの発信- 羊水塞栓症 まれな病気だが突然死に至ることも2008

    • Author(s)
      大井豪一
    • Publisher
      創元社
    • Related Report
      2010 Final Research Report
  • [Book] 医療の最先端 奈良医大からの発信羊水塞栓症 まれな病気だが突然死に至ることも2008

    • Author(s)
      大井 豪一
    • Total Pages
      5
    • Publisher
      創元社
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 破水および羊水塞栓症の検査方法2010

    • Inventor(s)
      小林浩、大井豪一、成瀬勝彦
    • Industrial Property Rights Holder
      アルフレッサファーマ株式会社
    • Filing Date
      2010-06-23
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 破水および羊水塞栓症の検査方法2009

    • Inventor(s)
      小林浩、大井豪一、成瀬勝彦
    • Industrial Property Rights Holder
      アルフレッサファーマ株式会社
    • Industrial Property Number
      2009-151914
    • Filing Date
      2009-06-26
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi