Elucidation of pathophysiology for abnormal decidualization and development of its treatment
| Project/Area Number |
20591928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
KAJIHARA Takeshi Saitama Medical University, 医学部, 准教授 (80286103)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Osamu 埼玉医科大学, 医学部, 教授 (70176212)
ITAKURA Atsuo 埼玉医科大学, 医学部, 教授 (70262897)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 子宮内膜脱落膜化 / 子宮内膜 / 脱落膜化 / SOD2 / 酸化ストレス / HCG / ヒト子宮内膜間質細胞 / フォークヘッド転写因子 / hCG |
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| Research Abstract |
To test this hypothesis, primary HESCs cultures were decidualized with 8-bromo-cAMP and medroxyprogesterone acetate in the presence or absence of rhCG at various concentrations. Hydrogen peroxide was used as a source of reactive oxygen species (ROS). rhCG conferred additional protection to oxidative cell death in decidualizing HESCs in a dose-dependent manner. In parallel, rhCG augmented the expression of the decidual transcription factor FOXO1 and its downstream target, the ROS scavenger superoxide dismutase 2 (SOD2). These results suggest that hCG improves the uterine environment upon implantation by suppressing apoptotic responses the maternal decidua under oxidative stress conditions.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Fezleabas ATProteomic analysis of endometrium fromfertile and infertile patients suggests arole for apolipoprotein A-1 in embryoimplantation failure and endometrium.2010
Author(s)
Brosens JJ, Hodgetts A, Feroze-Zaidi F, Sherwin JR, Fusi L, Salker MS, Higham J, Rose GL, Kajihara T, Young SL, Lessey BA, Henriet P, Langford PR
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Journal Title
Mol Hum Reprod 16
Pages: 273-285
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