Evaluation of the role of self-reactive T cells in liver dysfunction during pregnancy
| Project/Area Number |
20591932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Toshiyuki 日本医科大学, 大学院・医学研究科, 教授 (60188175)
SATOMI Misao 日本医科大学, 医学部, 助教 (80318500)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 産科学 / B7-H1 / 4-1BB / 妊娠 / 胎盤 / 流産 / 共刺激分子 / 自己傷害性T細胞 / Regulatory T cell |
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| Research Abstract |
In the liver of the B7-H1 knockout mouse, PD-1poitive T cell had accumulated and have potential to cause liver damage. However, those cells did not change the number during the pregnancy and did not seem to be associated with the liver damage. On the other hand, B7-H1 molecules on the placenta in mouse model could play a role in feto-maternal tolerance, because the group which was administered with anti-B7-H1 blocking antibody and anti-4-1BB antibody shows miscarriage in 22.2% compared with the control in 4.1%.
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Report
(4 results)
Research Products
(5 results)
