Basic research on the auto-transplantation of cryopresedved ovarian tissue - Aiming at the quality of life improvement of the young woman cancer patient.

• Project/Area Number: 20591933
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: St.Marianna University School of Medicine
• Principal Investigator: SUZUKI Nao St.Marianna University School of Medicine, 医学部, 准教授 (90246356)
• Co-Investigator(Kenkyū-buntansha): ISHIZUKA Bunpei 聖マリアンナ医科大学, 医学部, 教授 (80097336)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 卵巣組織凍結 / 若年女性癌患者 / ガラス化法 / カニクイザル / 自家移植 / 卵巣 / 凍結 / 移植 / 若年女性がん

Research Abstract

As for this study, the accomplishment of the study of the basics that intended the quality of life improvement as the woman after the treatment remission of the young woman cancer patient becomes the whole design. We established the new technology regarding the auto-transplantation of cryopreserved ovarian tissue ; the optimal method of cryopreservation and the appropriate site of auto-transplantation. Finally we succeeded to get the fertilized egg from the auto transplant part of the cryopreserved ovary (vitrification) organization in the primate for the first time in the world.

Research Products

• [Journal Article] 若年女性に対する卵巣組織凍結・自家移植の現状とその実際～最新の情報 (2010)
  • Author(s): 鈴木直、橋本周、五十嵐豪、高江正道、杉下陽堂、奥津由記、細井美彦、森本義晴、石塚文平
  • Journal Title: 産婦人科の実際 59 Pages: 1243-1249
• [Journal Article] Cryopreservation of ovarian tissue was possible after pre-treatment with a gonadotropin-releasing hormone agonist. (2010)
  • Author(s): Igarashi S, Suzuki N, Osada M, Takae S, Tarumi W, Ishizuka B
  • Journal Title: Reproductive Medicine and Biology 9
  • Peer Reviewed
• [Journal Article] 特集産婦人科診療~pros and cons~生殖細胞保存の有用性-妊孕性の温存を目的とした生殖細胞の超急速凍結保存- (2010)
  • Author(s): 橋本周、鈴木直、石塚文平、森本義晴
  • Journal Title: 産婦人科の実際 59 Pages: 367-374
• [Journal Article] Heterotopic auto-transplantation of ovarian cortex in cynomolgus monkeys. (2010)
  • Author(s): Igarashi S, Suzuki N, Hashimoto S, Takae S, Takenoshita M, Hosoi Y, Morimoto Y, Ishizuka B.
  • Journal Title: Human Cell 3 Pages: 26-34
  • Peer Reviewed
• [Journal Article] Heterotopic autotransplantation of ovarian cortex in cynomolgus monkeys. (2010)
  • Author(s): Igarashi S, et al
  • Journal Title: Human Cell Volume: 3 Pages: 26-34
  • Peer Reviewed
• [Journal Article] Effects of vitrification solutions and equibiration times on the morphology of cynomolgus ovarian tissues vitrified ultra-rapidly by direct plunging into liquid nitrogen (2010)
  • Author(s): Hashimoto S, et al
  • Journal Title: Reproductive BioMedicine Online Volume: 21 Pages: 501-509
  • Peer Reviewed
• [Journal Article] Cryopreservation of ovarian tissue was possible after pretreatment with a gonadotropin-releasing hormone agonist. (2010)
  • Author(s): Igarashi S, et al
  • Journal Title: Reproductive Medicine and Biology Volume: 9 Pages: 197-203
  • Peer Reviewed
• [Journal Article] 卵巣凍結保存・自家移植の現状 (2009)
  • Author(s): 鈴木直、高江正道、五十嵐豪、杉下陽堂、奥津由記、石塚文平
  • Journal Title: 臨床婦人科産科 63 Pages: 1373-1377
• [Journal Article] 特集妊孕能温存の婦人科がん治療がん化学療法と卵巣組織凍結-最近の話題- (2009)
  • Author(s): 鈴木直、五十嵐豪、高江正道、石塚文平
  • Journal Title: 産婦人科の実際 58 Pages: 309-315
• [Journal Article] 抗がん剤による化学療法が若年女性癌患者の妊孕性に及ぼす影響 (2009)
  • Author(s): 鈴木直、石塚文平
  • Journal Title: 脳神経外科ジャーナル 18 Pages: 361-366
  • Peer Reviewed
• [Presentation] ARTにおける技術革新:若年女性に対する卵巣組織凍結の現状 (2010)
  • Author(s): 鈴木直, 他
  • Organizer: 第13回日本IVF学会
  • Place of Presentation: 大阪府(グランキューブ大阪(大阪国際会議場))
  • Year and Date: 2010-09-19
• [Presentation] 【シンポジウム】ARTにおける技術革新:若年女性に対する卵巣組織凍結の現状 (2010)
  • Author(s): 鈴木直、石塚文平
  • Organizer: 第13回日本IVF学会
  • Place of Presentation: 大阪府(グランキューブ大阪(大阪国際会議場))
  • Year and Date: 2010-09-17
• [Presentation] 【シンポジウム】卵子、卵巣凍結保存の現状と展望:若年婦人患者のQOL向上を目指した卵巣組織凍結・自家移植-基礎から臨床へ (2010)
  • Author(s): 鈴木直、石塚文平
  • Organizer: 第28回日本受精着床学会総会・学術講演会
  • Place of Presentation: 神奈川県(パシフィコ横浜)
  • Year and Date: 2010-07-29
• [Presentation] 卵子、卵巣凍結保存の現状と展望:若年婦人患者のQOL向上を目指した卵巣組織凍結・自家移植-基礎から臨床へ (2010)
  • Author(s): 鈴木直, 他
  • Organizer: 第28回日本受精着床学会総会・学術講演会
  • Place of Presentation: 神奈川県(パシフィコ横浜)
  • Year and Date: 2010-07-29
• [Presentation] 【Selected Oral Presentation】Fertilized-ova from vitrified ovarian grafts in monkeys undergoing heterotopic autotransplantation : Development of a new vitrification technique. (2010)
  • Author(s): Suzuki N, Hashimoto S, Igarashi T, Takae S, Tsuji Y, Yamanaka M, Ohta S, Yamochi T, Takenoshita M, Hosoi Y, Morimoto Y, Ishizuka B.
  • Organizer: The 26th Annual Meeting of European Society of Human Reproduction and Embryo-logy 2010
  • Place of Presentation: Italy
  • Year and Date: 2010-06-29
• [Presentation] Fertilized-ova from vitrified ovarian grafts in monkeys undergoing heterotopic autotransplantation : Development of a new vitrification technique. (2010)
  • Author(s): Suzuki N, et al
  • Organizer: The 26th Annual Meeting of European Society of Human Reproduction and Embryology 2010
  • Place of Presentation: Italy
  • Year and Date: 2010-06-29
• [Presentation] 【Selected Oral Presentation】Heterotopic autotranplantation of ovarian cortex in cynomolgus monkeys. (2009)
  • Author(s): Suzuki N, Hashimoto S, Igarashi, Takae S, Tsuji Y, Ohta S, Yamochi T, Takenoshita M, Hosoi Y, Morimoto Y, Ishizuka B.
  • Organizer: World Congress on Fertility Preservation
  • Place of Presentation: Belgium
  • Year and Date: 2009-12-12
• [Presentation] 卵巣組織凍結の現状とその展望-若年婦人がん患者のQOL向上を目指して (2009)
  • Author(s): 鈴木直
  • Organizer: 第27回日本受精着床学会総会・学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-08-06
• [Presentation] 【プレナリーセッション、招請講演】挙児希望女性のoligodendrogliomaの術後化学療法:抗がん剤による化学療法が若年女性がん患者の妊孕性に及ぼう影響 (2008)
  • Author(s): 鈴木直、石塚文平
  • Organizer: 第28回日本脳神経外科コングレス総会
  • Place of Presentation: 神奈川県(パシフィコ横浜)
  • Year and Date: 2008-05-11
• [Presentation] カニクイザルを用いた卵巣組織自家移植に関する基礎的研究-若年女性がん患者のQOL向上を志向して (2008)
  • Author(s): 鈴木直、橋本周、五十嵐豪、井埜まり絵、高江正道、辻陽子、木口一成、細井美彦、森本義晴、石塚文平
  • Organizer: 第60回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 神奈川県(パシフィコ横浜)
  • Year and Date: 2008-04-13
• [Book] カラーアトラス 不妊診療のための卵子学 鈴木秋悦編 (2010)
  • Author(s): 鈴木直
  • Total Pages: 208
  • Publisher: 医師薬出版株式会社
• [Book] カラーアトラス不妊診療のための卵子学(鈴木秋悦編)(卵巣組織凍結保存法の現状) (2009)
  • Author(s): 鈴木直、橋本周、細井美彦、森本義晴、石塚文平
  • Publisher: 医歯薬出版、東京
• [Remarks] 鈴木直、石塚文平.効くNews Specialヨーロッパ生殖医学会発不妊治療の最前線レポート 卵巣凍結法による妊娠力温存に注目集まる、日経ヘルス、P.58-59、2010.9