Study on regulation of gene expression of a novel female reproductive organ-specific Type I interferon

• Project/Area Number: 20591934
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Hirosaki University
• Principal Investigator: MATSUMIYA Tomoh Hirosaki University, 大学院・医学研究科, 助教 (30344592)
• Co-Investigator(Kenkyū-buntansha): IMAIZUMI Tadaatsu 弘前大学, 大学院・医学研究科, 助教 (90232602) ; YOSHIDA Hidemi 弘前大学, 大学院・医学研究科, 講師 (40201008) ; SATOH Kei 弘前大学, 大学院・医学研究科, 教授 (20125438)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 婦人科学 / 婦人科免疫学 / 免疫応答 / 女性生殖器 / IFN-ε / 転写後調節

Research Abstract

IFN (interferon)-εhas recently found as a female reproductive-specific Type I IFN. From a point of view including sexually transmitted disease, it is important to understand local immune response in female-reproductive organs such as uterus and ovary ; however, it is incompletely understood. We elucidated a part of the mechanism of IFN-εgene expression. This result is expected to understand the local immune response in the female reproductive tissue.

Research Products

• [Journal Article] Antiviral signaling through retinoic acid-inducible gene-I-like receptors. (2011)
  • Author(s): Matsumiya T, Imaizumi T, Yoshida H, Satoh K
  • Journal Title: Arch Immunol Ther Exp(Warsz) 59(1) Pages: 41-8
• [Journal Article] IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells. (2010)
  • Author(s): Imaizumi T, Matsumiya T, 他
  • Journal Title: Am J Nephrol 32(5) Pages: 462-8
• [Journal Article] Function and regulation of retinoicacid-inducible gene-I. (2010)
  • Author(s): Matsumiya T, Stafforini DM
  • Journal Title: Crit Rev Immunol 30(6) Pages: 489-513
• [Journal Article] Characterization of synergistic induction of CX3CL1/fractalkine by TNF-α and IFN-γ in vascular endothelial cells: an essential role for TNF-α in post-transcriptional regulation of CX3CL1. (2010)
  • Author(s): Matsumiya T, Ota K, Imaizumi T, Yoshida H, Kimura H, Satoh K
  • Journal Title: J Immunol 184(8) Pages: 4205-14
• [Journal Article] Retinoic acid-inducible gene-I(RIG-I) is induced by IFN-gamma in human mesangial cells in culture : possible involvement of RIG-I in the inflammation in lupus nephritis. (2010)
  • Author(s): Imaizumi T, Tanaka H, Tajima A, Tsuruga K, Oki E, Sashinami H, Matsumiya T, Yoshida H, Inoue I, Ito E
  • Journal Title: Lupus 19(7) Pages: 830-6
• [Journal Article] Interferon-α2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells. (2010)
  • Author(s): Ota K, Matsumiya T, Sakuraba H, Imaizumi T, Yoshida H, Kawaguchi S, Fukuda S, Satoh K
  • Journal Title: Cell Cycle 9(1) Pages: 131-9
• [Journal Article] Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation. (2010)
  • Author(s): Yoshida H, Metoki N, Ishikawa A, Imaizumi T, Matsumiya T, Tanji K, Ota K, Ohyama C, Satoh K
  • Journal Title: Neurosci Res 66(3) Pages: 284-9
  • NAID: 10027501032
• [Journal Article] Characterization of Synergistic Induction of CX3CL1/Fractalkine by TNF-a and IFN-y in Vascular Endothelial Cells An Essential Role for TNF-o in Post-Transcrintiona1 Reeulation of CX3CL1. (2010)
  • Author(s): Matsumiya T, et al.
  • Journal Title: J Immunol Volume: 184 Pages: 4205-4214
  • Peer Reviewed
• [Journal Article] Interferon-alpha2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells. (2010)
  • Author(s): Ota K, et al.
  • Journal Title: Cell Cycle Volume: 9 Pages: 131-139
  • Peer Reviewed
• [Journal Article] The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha. (2009)
  • Author(s): Matsumiya T, Imaizumi T, Yoshida H, Satoh K, Topham MK, Stafforini DM
  • Journal Title: J Immunol 182(5) Pages: 2717-25
• [Journal Article] Tumor-necrosis factor-alpha induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes. (2009)
  • Author(s): Imaizumi T, Matsumiya T, Yoshida H, Naraoka T, Uesato R, Ishibashi Y, Ota K, Toh S, Fukuda S, Satoh K
  • Journal Title: Immunol Lett. 122(1) Pages: 89-93
• [Journal Article] The levels of Retinoic acid-inducible gene-I are regulated by heat shock protein 90-alpha (2009)
  • Author(s): Matsumiya T et at.
  • Journal Title: J.Immunol. 182 Pages: 2717-2725
  • Peer Reviewed
• [Journal Article] Expression of interferon-stimulated gene 20 in vascular endothelial cells. (2008)
  • Author(s): Imaizumi T, Mechti N, Matsumiya T, Sakaki H, Kubota K, Yoshida H, Kimura H, Satoh K
  • Journal Title: Microbiol Immunol 52(1) Pages: 30-35
  • NAID: 10025691025
• [Journal Article] Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells. (2008)
  • Author(s): Yuzawa E, Imaizumi T, Matsumiya T, Yoshida H, Fukuhara R, Kimura H, Fukui A, Tanji K, Mori F, Wakabayashi K, Fujii S, Mizunuma H, Satoh K
  • Journal Title: Life Sci 82(11-12) Pages: 670-5
• [Presentation] HuR regulates synergistic induction of CX3CL1 by TNF-alpha and IFN-gamma in vascular endothelial cells. (2010)
  • Author(s): Matsumiya T, Imaizumi T, Yoshida H,Satoh K
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe Japan
  • Year and Date: 2010-08-24
• [Presentation] HuR regulates synergistic induction of CX3CL1 by TNF-alpha and IFN gamma in vascular endothelial cells. (2010)
  • Author(s): Matsumiya T, et al.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場(神戸市)
  • Year and Date: 2010-08-24
• [Presentation] Heat shock protein 90 protects degradation of retinoic acid-inducible gene-I. (2009)
  • Author(s): Matsumiya T, Imaizumi T, Yoshida H, Topham MK, Stafforini DM, Satoh K
  • Organizer: 96^<th> Annual meeting of the American Association of Immunologist.
  • Place of Presentation: Seattle, USA
  • Year and Date: 2009-05-11
• [Remarks] ホームページ等