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Study on regulation of gene expression of a novel female reproductive organ-specific Type I interferon

Research Project

Project/Area Number 20591934
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHirosaki University

Principal Investigator

MATSUMIYA Tomoh  Hirosaki University, 大学院・医学研究科, 助教 (30344592)

Co-Investigator(Kenkyū-buntansha) IMAIZUMI Tadaatsu  弘前大学, 大学院・医学研究科, 助教 (90232602)
YOSHIDA Hidemi  弘前大学, 大学院・医学研究科, 講師 (40201008)
SATOH Kei  弘前大学, 大学院・医学研究科, 教授 (20125438)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords婦人科学 / 婦人科免疫学 / 免疫応答 / 女性生殖器 / IFN-ε / 転写後調節
Research Abstract

IFN (interferon)-εhas recently found as a female reproductive-specific Type I IFN. From a point of view including sexually transmitted disease, it is important to understand local immune response in female-reproductive organs such as uterus and ovary ; however, it is incompletely understood. We elucidated a part of the mechanism of IFN-εgene expression. This result is expected to understand the local immune response in the female reproductive tissue.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Antiviral signaling through retinoic acid-inducible gene-I-like receptors.2011

    • Author(s)
      Matsumiya T, Imaizumi T, Yoshida H, Satoh K
    • Journal Title

      Arch Immunol Ther Exp(Warsz) 59(1)

      Pages: 41-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells.2010

    • Author(s)
      Imaizumi T, Matsumiya T, 他
    • Journal Title

      Am J Nephrol 32(5)

      Pages: 462-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Function and regulation of retinoicacid-inducible gene-I.2010

    • Author(s)
      Matsumiya T, Stafforini DM
    • Journal Title

      Crit Rev Immunol 30(6)

      Pages: 489-513

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of synergistic induction of CX3CL1/fractalkine by TNF-α and IFN-γ in vascular endothelial cells: an essential role for TNF-α in post-transcriptional regulation of CX3CL1.2010

    • Author(s)
      Matsumiya T, Ota K, Imaizumi T, Yoshida H, Kimura H, Satoh K
    • Journal Title

      J Immunol 184(8)

      Pages: 4205-14

    • Related Report
      2010 Final Research Report
  • [Journal Article] Retinoic acid-inducible gene-I(RIG-I) is induced by IFN-gamma in human mesangial cells in culture : possible involvement of RIG-I in the inflammation in lupus nephritis.2010

    • Author(s)
      Imaizumi T, Tanaka H, Tajima A, Tsuruga K, Oki E, Sashinami H, Matsumiya T, Yoshida H, Inoue I, Ito E
    • Journal Title

      Lupus 19(7)

      Pages: 830-6

    • Related Report
      2010 Final Research Report
  • [Journal Article] Interferon-α2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells.2010

    • Author(s)
      Ota K, Matsumiya T, Sakuraba H, Imaizumi T, Yoshida H, Kawaguchi S, Fukuda S, Satoh K
    • Journal Title

      Cell Cycle 9(1)

      Pages: 131-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.2010

    • Author(s)
      Yoshida H, Metoki N, Ishikawa A, Imaizumi T, Matsumiya T, Tanji K, Ota K, Ohyama C, Satoh K
    • Journal Title

      Neurosci Res 66(3)

      Pages: 284-9

    • NAID

      10027501032

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of Synergistic Induction of CX3CL1/Fractalkine by TNF-a and IFN-y in Vascular Endothelial Cells An Essential Role for TNF-o in Post-Transcrintiona1 Reeulation of CX3CL1.2010

    • Author(s)
      Matsumiya T, et al.
    • Journal Title

      J Immunol

      Volume: 184 Pages: 4205-4214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-alpha2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells.2010

    • Author(s)
      Ota K, et al.
    • Journal Title

      Cell Cycle

      Volume: 9 Pages: 131-139

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.2009

    • Author(s)
      Matsumiya T, Imaizumi T, Yoshida H, Satoh K, Topham MK, Stafforini DM
    • Journal Title

      J Immunol 182(5)

      Pages: 2717-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tumor-necrosis factor-alpha induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes.2009

    • Author(s)
      Imaizumi T, Matsumiya T, Yoshida H, Naraoka T, Uesato R, Ishibashi Y, Ota K, Toh S, Fukuda S, Satoh K
    • Journal Title

      Immunol Lett. 122(1)

      Pages: 89-93

    • Related Report
      2010 Final Research Report
  • [Journal Article] The levels of Retinoic acid-inducible gene-I are regulated by heat shock protein 90-alpha2009

    • Author(s)
      Matsumiya T et at.
    • Journal Title

      J.Immunol. 182

      Pages: 2717-2725

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of interferon-stimulated gene 20 in vascular endothelial cells.2008

    • Author(s)
      Imaizumi T, Mechti N, Matsumiya T, Sakaki H, Kubota K, Yoshida H, Kimura H, Satoh K
    • Journal Title

      Microbiol Immunol 52(1)

      Pages: 30-35

    • NAID

      10025691025

    • Related Report
      2010 Final Research Report
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells.2008

    • Author(s)
      Yuzawa E, Imaizumi T, Matsumiya T, Yoshida H, Fukuhara R, Kimura H, Fukui A, Tanji K, Mori F, Wakabayashi K, Fujii S, Mizunuma H, Satoh K
    • Journal Title

      Life Sci 82(11-12)

      Pages: 670-5

    • Related Report
      2010 Final Research Report
  • [Presentation] HuR regulates synergistic induction of CX3CL1 by TNF-alpha and IFN-gamma in vascular endothelial cells.2010

    • Author(s)
      Matsumiya T, Imaizumi T, Yoshida H,Satoh K
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe Japan
    • Year and Date
      2010-08-24
    • Related Report
      2010 Final Research Report
  • [Presentation] HuR regulates synergistic induction of CX3CL1 by TNF-alpha and IFN gamma in vascular endothelial cells.2010

    • Author(s)
      Matsumiya T, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Heat shock protein 90 protects degradation of retinoic acid-inducible gene-I.2009

    • Author(s)
      Matsumiya T, Imaizumi T, Yoshida H, Topham MK, Stafforini DM, Satoh K
    • Organizer
      96^<th> Annual meeting of the American Association of Immunologist.
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2009-05-11
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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