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Uterine leiomyoma and metabolic syndrome-a new therapeutic strategy

Research Project

Project/Area Number 20591945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

TAKEDA Takashi  Tohoku University, 大学院・医学系・研究科, 准教授 (20301260)

Co-Investigator(Kenkyū-buntansha) 築地 謙治 (築地 賢治)  東北大学, 大学院・医学系研究科, 助手 (40528155)
森重 健一郎  大阪大学, 医学系研究科, 准教授 (90283788)
澤田 健二郎  大阪大学, 医学部・附属病院, 助教 (00452392)
坂田 正博  大阪大学, 医学部・附属病院, 准教授 (10260639)
馬淵 誠士  大阪大学, 医学系・研究科, 助教 (00452441)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords子宮筋腫 / メタボリックシンドローム / アンジオテンシン / アルドステロン / アディポネクチン / クルクミン / 移植モデル / ヒト子宮筋腫モデル / メトホルミン / PPARγ / AMPK / mTOR / スピロノラクトン / アンギオテンシン / ELT-3細胞 / ヌードマウス / 高血圧
Research Abstract

We have shown that Ang II and aldosterone could potentiate the proliferation of leiomyoma cells. We have further shown that adiponectin, genistein and curcumin repressed the proliferation of leiomyoma cells. We have also established a novel xenograft model for uterine leiomyoma.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (6 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Inhibitory effect of curcumin on uterine leiomyoma cell proliferation.2011

    • Author(s)
      Tsuiji K, Takeda T, Li B, Wakabayashi A, Kondo A, Kimura T, Yaegashi N.
    • Journal Title

      Gynecol Endocrinol.

      Volume: 27 Pages: 512-517

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells.2011

    • Author(s)
      Wakabayashi A, Takeda T, Tsuiji K, Li B, Sakata M, Morishige KI, Yaegashi N, Kimura T.
    • Journal Title

      Gynecol Endocrinol.

      Volume: 27 Pages: 33-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Novel Xenograft Model for Human Uterine Leiomyoma in Immunodeficient2010

    • Author(s)
      Mice Tsuiji K, Takeda T, Li B, Kondo A, Ito M, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med. 222(1)

      Pages: 55-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of curcumin on uterine leiomyoma cell proliferation.2010

    • Author(s)
      Tsuiji K, Takeda T, Li B, Wakabayashi A, Kondo A, Kimura T, Yaegashi N
    • Journal Title

      Gynecol Endocrinol. Jul 30(Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells.2010

    • Author(s)
      Wakabayashi A, Takeda T, Tsuiji K, Li B, Sakata M, Morishige KI, Yaegashi N, Kimura T.
    • Journal Title

      Gynecol Endocrinol. May 26(Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone stimulates the proliferation of uterine leiomyoma2010

    • Author(s)
      Isobe A, Takeda T, Wakabayashi A, Tsuiji K, Li B, Sakata M, Yaegashi N, Kimura T
    • Journal Title

      Gynecol Endocrinol. 26(5)

      Pages: 372-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Novel Xenograft Model for Human Uterine Leiomyoma in Immunodeticient Mice2010

    • Author(s)
      Tsuiji K, Takeda T, Li B, Kondo A, Ito M, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 222 Pages: 55-61

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone stimulates the proliferation of uterine leiomyoma2010

    • Author(s)
      Isobe A, Takeda T, Wakabayashi A, Tsuiji K, Li B, Sakata M, Yaegashi N, Kimura T.
    • Journal Title

      Gynecol Endocrinol. (未定, 印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation2009

    • Author(s)
      Miyake A, Takeda T,他
    • Journal Title

      Gynecol Endocrinol. 25(6)

      Pages: 403-409

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation2009

    • Author(s)
      Miyake A, Takeda T, Isobe A, Wakabayashi A, Nishimoto F, Morishige KI, Sakata M, Kimura T.
    • Journal Title

      Gynecological Endocrinology. 25

      Pages: 403-409

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of{alpha}5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.2009

    • Author(s)
      Arimoto-Ishida E, Sakata M, Sawada K, Nakayama M, Nishimoto F, Mabuchi S, Takeda T, Yamamoto T, Isobe A, Okamoto Y, Lengyel E, Suehara N, Morishige KI, Kimura T.
    • Journal Title

      Endocrinology. 150

      Pages: 4306-43115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal Transcription Factor-1 is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells.2009

    • Author(s)
      Nishimoto F, Sakata M, Minekawa R, Okamoto Y, Miyake A, Isobe A, Yamamoto T, Takeda T, Ishida E, Sawada K, Morishige KI, Kimura T.
    • Journal Title

      Endocrinology. 150

      Pages: 1801-1808

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated level of plasma vascular endothelial growth factor after gonadotropin-releasing hormone agonist treatment for leiomyomata.2008

    • Author(s)
      Takeda T,他
    • Journal Title

      Gynecol Endocrinol. 24(12)

      Pages: 724-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful management of a leiomyomatosis peritonealis disseminata with aromatase inhibitor2008

    • Author(s)
      Takeda T, Masuhara K, Kamiura S
    • Journal Title

      Obstetrics & Gynecology 112(2Pt2)

      Pages: 491-493

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between metabolic syndrome and uterine leiomyomata : a case-control study2008

    • Author(s)
      Takeda, T. Sakata, M. Isobe, A. Miyake, A. Nishimoto, F. Ota, Y. Kamiura, S. Kimura, T.
    • Journal Title

      Gynecol Obstet Invest 66

      Pages: 14-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation2008

    • Author(s)
      Isobe, S. Takeda, T. Sakata, M. Miyake, A. Yamamoto, T. Minekawa, R. Nishimoto, F. Okamoto, Y. Walker, L. Kimura, T.
    • Journal Title

      Hum Reprod 23

      Pages: 440-446

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful management of a leiomyomatosis peritonealis disseminata with aromatase inhibitor2008

    • Author(s)
      Takeda, T. Masuhara, K. Kamiura, S.
    • Journal Title

      Obstetrics & Gynecology 112

      Pages: 491-493

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of the Herbal Medicine, Daikenchuto, for Radiation-Induced Enteritis2008

    • Author(s)
      Takeda T, Kamiura S, Kimura T
    • Journal Title

      Journal of Alternative and Complementary Medicine 66

      Pages: 14-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 特別講演「メタボリックシンドロームからみた子宮筋腫に対する新しい治療戦略」2011

    • Author(s)
      武田卓
    • Organizer
      日本産科婦人科学会岩手地方部会学術講演会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-01-15
    • Related Report
      2010 Final Research Report
  • [Presentation] メタボリックシンドロームからみた子宮筋腫に対する新しい治療戦略2011

    • Author(s)
      武田卓
    • Organizer
      日本産科婦人科学会岩手地方部会学術講演会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-01-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] <招待講演>「子宮筋腫モデル開発にむけて」2009

    • Author(s)
      武田卓
    • Organizer
      東北大学・実験動物中央研究所組織的連携 第1回シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] アディポネクチンは子宮筋腫細胞増殖を抑制する2009

    • Author(s)
      若林敦子、武田卓、三宅麻子、磯部晶、石田絵美、西本文人、森重健一郎、坂田正博、木村正
    • Organizer
      第61回日本産科婦人科学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-03
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 子宮筋腫における新しい細胞増殖シグナル伝達機構解析(子宮筋腫に対する子宮動脈塞栓術から分子標的療法へ)2008

    • Author(s)
      武田卓
    • Organizer
      第6回愛知子宮筋腫塞栓療法検討会特別講演
    • Place of Presentation
      名古屋
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] メタボリックシンドロームは子宮筋腫発症の危険因子か?2008

    • Author(s)
      武田卓、坂田正博、三宅麻子、磯部晶、西本文人、太田行信、森重健一郎、上浦祥司、木村正
    • Organizer
      第60回日本産科婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-12
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.ob-gy.med.tohoku.ac.jp/laboratory/t-takeda.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ob-gy.med.tohoku.ac.jp/laboratory/t-takeda.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kanpou.med.tohoku.ac.jp/study1.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒト子宮筋腫モデル動物の作製方法2009

    • Inventor(s)
      武田卓
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2009-297958
    • Filing Date
      2009-12-25
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 子宮筋腫細胞増殖抑制剤及びこれを含む子宮筋腫の予防又は治療薬2009

    • Inventor(s)
      武田卓
    • Industrial Property Rights Holder
      武田卓
    • Filing Date
      2009-12-11
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 子宮筋腫細胞増殖抑制剤及びこれを含む子宮筋腫の予防又は治療薬2008

    • Inventor(s)
      武田卓
    • Industrial Property Rights Holder
      大阪大学
    • Filing Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
    • Overseas

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Published: 2008-04-01   Modified: 2016-04-21  

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