Uterine leiomyoma and metabolic syndrome-a new therapeutic strategy
| Project/Area Number |
20591945
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
TAKEDA Takashi Tohoku University, 大学院・医学系・研究科, 准教授 (20301260)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
築地 謙治 (築地 賢治) 東北大学, 大学院・医学系研究科, 助手 (40528155)
森重 健一郎 大阪大学, 医学系研究科, 准教授 (90283788)
澤田 健二郎 大阪大学, 医学部・附属病院, 助教 (00452392)
坂田 正博 大阪大学, 医学部・附属病院, 准教授 (10260639)
馬淵 誠士 大阪大学, 医学系・研究科, 助教 (00452441)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 子宮筋腫 / メタボリックシンドローム / アンジオテンシン / アルドステロン / アディポネクチン / クルクミン / 移植モデル / ヒト子宮筋腫モデル / メトホルミン / PPARγ / AMPK / mTOR / スピロノラクトン / アンギオテンシン / ELT-3細胞 / ヌードマウス / 高血圧 |
|---|
| Research Abstract |
We have shown that Ang II and aldosterone could potentiate the proliferation of leiomyoma cells. We have further shown that adiponectin, genistein and curcumin repressed the proliferation of leiomyoma cells. We have also established a novel xenograft model for uterine leiomyoma.
|
Report
(4 results)
Research Products
(30 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Up-regulation of{alpha}5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.2009
Author(s)
Arimoto-Ishida E, Sakata M, Sawada K, Nakayama M, Nishimoto F, Mabuchi S, Takeda T, Yamamoto T, Isobe A, Okamoto Y, Lengyel E, Suehara N, Morishige KI, Kimura T.
-
Journal Title
Endocrinology. 150
Pages: 4306-43115
Related Report
Peer Reviewed
-
[Journal Article] Metal Transcription Factor-1 is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells.2009
Author(s)
Nishimoto F, Sakata M, Minekawa R, Okamoto Y, Miyake A, Isobe A, Yamamoto T, Takeda T, Ishida E, Sawada K, Morishige KI, Kimura T.
-
Journal Title
Endocrinology. 150
Pages: 1801-1808
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation2008
Author(s)
Isobe, S. Takeda, T. Sakata, M. Miyake, A. Yamamoto, T. Minekawa, R. Nishimoto, F. Okamoto, Y. Walker, L. Kimura, T.
-
Journal Title
Hum Reprod 23
Pages: 440-446
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
