| Project/Area Number |
20591946
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kobe University |
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Principal Investigator |
YOSHIDA Shigeki Kobe University, 医学研究科, 准教授 (70294212)
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| Co-Investigator(Kenkyū-buntansha) |
OHARA Noriyuki 神戸大学, 大学院・医学研究科, 医学研究員 (70214210)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 婦人科学 / 子宮内膜症 / 遺伝子多型 / TDT解析 / SNP / 一塩基遺伝子多型 |
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| Research Abstract |
In this project, we investigated whether polymorphisms in several endometriosis candidate genes including TNF-beta, E-cadherin, Transforming growth factor beta1, CYP1B1, tumor necrosis factors-beta, Interleukin-10, were associated with endometriosis in a Japanese population. Genotyping of single nucleotide polymorphisms (SNPs) were performed in endometriosis cases diagnosed by laparoscopy at a university hospitals and controls, by polymerase chain reaction-restriction fragment length polymorphism analysis. We compared the genotype distributions and allele frequency of these polymorphisms between endometriosis patients and controls.
However, no significant differences in the frequency and genotype distributions of all of these polymorphisms were found between the endometriosis patients and controls. Moreover, stratification by disease stage also revealed that there were no significant differences between endometriosis cases and controls in all of these SNPs studied.
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