| Project/Area Number |
20591953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Kyushu University |
|---|
Principal Investigator |
小川 伸二 Kyushu University, 大学病院, 助教 (60380391)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hiroaki 九州大学, 大学病院, 准教授 (70260700)
SONODA Kenzo 九州大学, 大学病院, 講師 (30294929)
YAHATA Hideaki 九州大学, 大学病院, 助教 (30404065)
OKUGAWA Kaoru 九州大学, 大学病院, 助教 (90452789)
KANEKI Eisuke 九州大学, 大学病院, 助教 (90423508)
ABE Koichiro 九州大学, 大学病院, 助教 (00380387)
WAKE Norio 九州大学, 医学研究院, 教授 (50158606)
谷口 秀一 九州大学, 大学病院, 助教 (70452711)
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|---|
| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 子宮頸癌 / センチネルリンパ節 / SNNS / 外科 / 縮小手術 / sentinel node navigation surgery |
|---|
| Research Abstract |
We assessed feasibility andaccuracy of sentinel lymph nodes (SN) detection using 99mTc phytate in patients with cervical cancer. A total of 157 lymph nodes were detected asSNs in 72 of 82 patients. SN detection rate was 95% for the subgroups of patients withstage Ia-Ib1 disease and smaller tumor size (3 cm in maximal diameter).
Lymph node metastasis was found in 15 patients. In 3 of them, no SLNs were detected. In theremaining 12 patients, each ipsilateral SLN contained metastasis when the pelvic lymph nodes contained metastases. Sensitivity was 100%, the false negative rate was0%, and the negative predictive value of SLN was 100%. SN detection using 99mTc labeled phytate is satisfactory to assess pelvic nodes in patients with early cervical cancer.
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