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Bio-function of glycolipids in uterine endometrial adencarcinoma and cervical carcinoma, and uterine endometrium

Research Project

Project/Area Number 20591962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTokai University

Principal Investigator

MIKAMI Mikio  Tokai University, 医学部, 教授 (30190606)

Research Collaborator IWAMORI Masao  近畿大学, 理工学部, 教授 (90110022)
IWAMORI Masao  国立成育医療センター研究所, 研究部, 部長 (70213486)
MIYAZAWA Masaki  東海大学, 医学部・大学院
GOTO Yumiko  東海大学, 医学部・大学院
NISHIJIMA Yoshihiro  東海大学, 医学部・大学院
SUGIYAMA Taro  東海大学, 医学部, 助教 (90439696)
IKEDA Masae  東海大学, 医学部, 講師 (20365993)
SHIDA Masako  東海大学, 医学部, 講師 (10338717)
HIRASAWA Takeshi  東海大学, 医学部, 講師 (70307289)
MURAMATSU Toshinari  東海大学, 医学部, 准教授 (90266437)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords子宮体癌 / 子宮頸癌 / 子宮内膜 / 分化度 / 腺腔形成 / 糖脂質・硫酸化糖脂質 / スルファチド / レクチンアレイ / 組織分化度 / 糖脂質 / 硫酸化糖脂質 / コレステロール硫酸
Research Abstract

Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. In this study, we have clarified that "sulfation of glycolipid contributes to the differentiation of endometrial cancer, and that by the lectin array evaluating carbohydrate chains of the glycoproteins, the differentiation and staging of endometrial cancer can be correctly diagnosed, and that in uterine cervical cancers, the sulfation of glycolipids occurs only in adenocarcinomas and small cell carcinomas, and CST (Cerebroside sulfotransferase might be involved in cancer invasion.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (37 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (10 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Granulosa cell tumor with activated mTOR-HIF-1α-VEGF pathway2010

    • Author(s)
      Miyazawa M, Mikami M(他)
    • Journal Title

      Journal of Obstetrics Gynaecology Research vol.36

      Pages: 448-453

    • NAID

      10031121639

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of α2,6-sialic acid-containing and Lewis-active glycolipids in several types of human ovarian carcinomas2010

    • Author(s)
      Tanaka K, Mikami M(他)
    • Journal Title

      ONCOLOGY LETTERS vol.1

      Pages: 1061-1066

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the differentiation of cultured endometrial carcinoma cells by type I collagen : Relevance of sulfolipids2010

    • Author(s)
      Mikami M, Iwamori M(他)
    • Journal Title

      ONCOLOGY LETTERS vol.1

      Pages: 113-117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Granulosa cell tumor with activated mTOR-HIF-1α-VEGF pathway2010

    • Author(s)
      Masaki Miyazawa
    • Journal Title

      Journal of Obstetrics Gynaecology Research

      Volume: 36 Pages: 448-453

    • NAID

      10031121639

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of α2, 6-sialic acid-containing and Lewis-active glycolipids in several types of human ovarian carcinomas2010

    • Author(s)
      Kyoko Tanaka
    • Journal Title

      ONCOLOGY LETTERS

      Volume: 1 Pages: 1061-1066

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the differentiation of cultured endometrial carcinoma cells by type I collagen : Relevance of sulfolipids2010

    • Author(s)
      Mikio Mikami
    • Journal Title

      ONWLOGY LETTERS 1

      Pages: 113-117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors : a quantitative analysis of HIF-12009

    • Author(s)
      Miyazawa M, Mikami M(他)
    • Journal Title

      Archives of Gynecology and Obstetrics vol.279

      Pages: 789-796

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clear cell adenocarcinoma arising from adenomyosis2009

    • Author(s)
      Hirabayashi K, Mikami M(他)
    • Journal Title

      International Journal of Gynecological Pathology vol.28

      Pages: 262-266

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic strategy targeting the mTOR-HIF-1α-VEGF pathway in ovarian clear cell adenocarcinoma2009

    • Author(s)
      Miyazawa M, Mikami M(他)
    • Journal Title

      Pathology International vol.59

      Pages: 19-27

    • NAID

      10027378890

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors : a quantitative analysis of HIF-12009

    • Author(s)
      Masaki Miyazawa
    • Journal Title

      Archives of Gynecology and Obstetrics 279

      Pages: 789-796

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clear Cell Adenocarcinoma Arising From Adenomyosis2009

    • Author(s)
      Kenichi Hirabayashi
    • Journal Title

      International Journal of Gynecological Pathology 28

      Pages: 262-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      三上幹男
    • Journal Title

      講義録産科婦人科学(メジカルビュー社)

      Pages: 1-491

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Therapeutic strategy targeting the mTOR-HIF-1α-VEGF pathway in ovarian clear cell adenocarcinoma2009

    • Author(s)
      Masaki Miyazawa
    • Journal Title

      Pathology International 59

      Pages: 19-27

    • NAID

      10027378890

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in Mucin Expression in Ovarian Mucinous Tumors : Immunohistochemical Analysis of MUC2, MUC5AC, MUC6, and CD10 Expression2008

    • Author(s)
      Hirabayashi K, Mikami M(他)
    • Journal Title

      Acta Histochemica et Cytochemica vol.41

      Pages: 15-21

    • NAID

      130000070699

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxic status in ovarian serous and mucinous tumors : Relationship between histological characteristics and HIF-1α/GLUT-1 expression2008

    • Author(s)
      Iida T, Mikami M(他)
    • Journal Title

      Archives of Gynecology and Obstetrics vol.277

      Pages: 539-546

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in Mucin Expression in Ovarian Mucinous Tumors : Immunohistochemical Analysis of MUC2, MUC5AC, MUC6, and CD10 Expression2008

    • Author(s)
      Kenichi Hirabayashi
    • Journal Title

      Aota Histochemica et Cytochemica 41

      Pages: 15-21

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxic status in ovarian serous and mucinous tumors : relationship between histological characteristics and HIF-1α /GLUT-1 expression2008

    • Author(s)
      Tetsuji Iida
    • Journal Title

      Archives of Gynecology and Obstetrics 277

      Pages: 539-546

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] レクチンアレイを用いた子宮内膜・子宮体癌に発現する糖蛋白糖鎖の探索2010

    • Author(s)
      杉山太朗
    • Organizer
      第49回日本臨床細胞学会秋期大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-11-22
    • Related Report
      2010 Final Research Report
  • [Presentation] レクチンアレイを用いた子宮内膜・子宮体癌に発現する糖蛋白糖鎖の探索2010

    • Author(s)
      杉山太朗
    • Organizer
      第49回日本臨床細胞学会秋期大会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2010-11-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] DETECTION OF SUGAR CHAINS OF GLYCOPROTEINS EXPRESSED BY NORMAL ENDMETRIUM AND UTERINE ENDOMETRIAL CANCER (WELL-DIFFERENTIATED AND POORLY-DIFFERENTIATED) WITH THE LECTIN ARRAYS2010

    • Author(s)
      Y.Nishijima
    • Organizer
      13th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Prague
    • Year and Date
      2010-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ENHANCED EXPRESSION OF SULFATIDES IN THE WELL-DIFFERENTIATED TYPE OF HUMAN ENDOMETRIAL ADENOCARCINOMA2010

    • Author(s)
      T.Sugiyama
    • Organizer
      13th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Prague
    • Year and Date
      2010-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] レクチンアレイを用いた子宮内膜・子宮体癌(高分化型・低分化型)に発現する糖蛋白糖鎖の検索2010

    • Author(s)
      西島義博
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮頸部腺癌ではスルファチドの発現が亢進している2010

    • Author(s)
      杉山太朗
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] レクチンアレイを用いた子宮内膜・子宮体癌(高分化型・低分化型)に発現する糖蛋白糖鎖の検索2010

    • Author(s)
      西島義博
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] レクチンアレイを用いた着床期子宮内膜に発現する糖蛋白糖鎖の検索2010

    • Author(s)
      杉山太朗
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 高分化型類内膜子宮体癌ではスルファチドの発現が亢進している2009

    • Author(s)
      杉山太朗
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 高分化型内膜腺癌では硫酸化脂質の合成・発現が亢進している2009

    • Author(s)
      杉山太朗
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-04
    • Related Report
      2010 Final Research Report
  • [Book] OGS NOW No.62010

    • Author(s)
      三上幹男,他
    • Publisher
      メジカルビュー社出版
    • Related Report
      2010 Final Research Report
  • [Book] 講義録産科婦人科学2009

    • Author(s)
      三上幹男,他
    • Publisher
      メジカルビュー社出版
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.u-tokai.ac.jp/daigakuin/pdf/mikami.pdf

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.u-tokai.ac.jp/daigakuin/pdf/mikami.pdf

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.u-tokai.ac.jp/daigakuin/pdf/mikami.pdf

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.u-tokai.ac.jp/daigakuin/pdf/mikami.pdf

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] METHOD FOR DIAGNOSING ENDOMETRIAL CANCER2011

    • Inventor(s)
      三上幹男、梅澤明弘
    • Industrial Property Rights Holder
      東海大学
    • Filing Date
      2011-01-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] METHOD FOR DIAGNOSING ENDOMETRIAL CANCER2011

    • Inventor(s)
      三上幹男, 梅澤明弘
    • Industrial Property Rights Holder
      東海大学
    • Filing Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 子宮体癌の診断方法2010

    • Inventor(s)
      三上幹男、梅澤明弘
    • Industrial Property Rights Holder
      東海大学
    • Filing Date
      2010-07-13
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 子宮体癌の診断方法2010

    • Inventor(s)
      三上幹男, 梅澤明弘
    • Industrial Property Rights Holder
      東海大学
    • Industrial Property Number
      2010-158575
    • Filing Date
      2010-07-13
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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