Analysis of the eustachian tubal cell secretion in the cell culture and its clinical aspects

• Project/Area Number: 20591968
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: OSHIMA Takeshi Tohoku University, 大学院・医学系・研究科, 准教授 (40241608)
• Co-Investigator(Kenkyū-buntansha): KAWASE Tetsuaki 東北大学, 大学院・医工学研究科, 教授 (50169728)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 耳管開放症 / 鼻すすり / 耳管機能 / 生食点鼻 / 耳管 / 体重減少

Research Abstract

The eustachian tube function was evaluated quantitatively in the rat, and then tubal opening and closing pressure was decreased by postural change and starvation. Primary cell culture of tubal epithelial and gland cells was attempted to examine the effect of the tubal mucosal secretion to the tubal function. Clinically, nasal instillation of saline was shown to be effective to patulous eustachian tube. Its mechanism is considered to be mechanical tubal closure and possible modulation of tubal secretion.

Research Products

• [Journal Article] Management of Patulous Eustachian Tube With Habitual Sniffing. (2011)
  • Author(s): Ikeda R, Oshima T, Kikuchi T, Miyazaki M, Kobayashi T.
  • Journal Title: Otol Neurotol (in press 発行予定)
  • Peer Reviewed
• [Journal Article] Nasal instillation of physiological saline for patulous eustachian tube. (2010)
  • Author(s): Oshima T, Kikuchi T, Kawase T, Kobayashi T
  • Journal Title: Acta Oto-Laryngologica 130 Pages: 550-553
  • Peer Reviewed
• [Journal Article] Nasal instillation of physiological saline for patulous eustachian tube. (2010)
  • Author(s): Oshima T, Kikuchi T, Kawase T, Kobayashi T.
  • Journal Title: Acta Oto-Laryngologica Volume: 130 Pages: 550-553
  • Peer Reviewed
• [Journal Article] 耳管開放症 (2010)
  • Author(s): 大島猛史
  • Journal Title: JOHNS 26 Pages: 327-329
• [Journal Article] Three-dimensional computed tomography imaging of the eustachian tube lumen in patients with patulous eustachian tube (2010)
  • Author(s): Kikuchi T, Oshima T, Hori Y, Kawase T, Kobayashi T
  • Journal Title: ORL 71 Pages: 312-316
  • Peer Reviewed
• [Journal Article] Masked patulous eustachian tube : an important diagnostic precaution before middle ear surgery. (2009)
  • Author(s): Kobayashi T, Hasegawa J, Kikuchi T, Suzuki T, Oshima T, Kawase T
  • Journal Title: Tohoku J Exp Med 218 Pages: 317-324
  • NAID: 10025107141
  • Peer Reviewed
• [Journal Article] Three-dimensional computed tomography imaging of the eustachian tube lumen in patients with patulous eustachian tube. (2009)
  • Author(s): Kikuchi T, Oshima T, Hori Y, Kawase T, Kobayashi T.
  • Journal Title: ORL 71 Pages: 312-316
  • Peer Reviewed
• [Presentation] 鼻すすり型耳管開放症の治療方針 (2010)
  • Author(s): 大島猛史、池田怜吉、菊地俊晶、大島英敏、川瀬哲明、小林俊光
  • Organizer: 第20回日本耳科学会
  • Place of Presentation: 松山
  • Year and Date: 2010-10-08
• [Presentation] 遮蔽型耳管解放症-術前耳管機能検査の重要性- (2010)
  • Author(s): 宮崎真紀子、菊地俊晶、大島英敏、池田怜吉、大島猛史、川瀬哲明、小林俊光、
  • Organizer: 第20回日本耳科学会
  • Place of Presentation: 松山
  • Year and Date: 2010-10-08
• [Presentation] Management of patulous eustachian tube with sniffing habit. (2010)
  • Author(s): Oshima T, Ikeda R, Oshima H, Miyazaki M, Kikuchi T, Kawase T, Kobayashi T
  • Organizer: 13th Korea-Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: Seoul
  • Year and Date: 2010-09-11
• [Presentation] 耳管疾患の最前線 (2010)
  • Author(s): 大島猛史
  • Organizer: 第111回日本耳鼻咽喉科学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-21
• [Presentation] Nasal instillation of physiological saline for patulous eustachian tube. (2009)
  • Author(s): Oshima T, Kikuchi T, Kawase T, Kobayashi T
  • Organizer: 10th Taiwan-Japan Otolaryngology Head & Neck Conference
  • Place of Presentation: Yilan (Taiwan)
  • Year and Date: 2009-12-05
• [Presentation] 体位、血圧変化によるラット耳管機能の変化 (2009)
  • Author(s): 宮崎真紀子、堀容子、大島猛史、千葉敏彦、菊地俊晶、川瀬哲明、小林俊光
  • Organizer: 第19回日本耳科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-10
• [Presentation] Mechanism of eustachian tbe closure evoked by neck compression in patients with patulous eustachan tube. (2009)
  • Author(s): Oshima T, Kikuchi T, Kawase T, Kobayashi T
  • Organizer: 6th extraordinary international symposium on recent advances in otitis media
  • Place of Presentation: Seoul
  • Year and Date: 2009-05-09
• [Presentation] 体重減少に関連した耳管開放症に対する点鼻療法の効果 (2008)
  • Author(s): 大島猛史、菊地俊晶、川瀬哲明、小林俊光
  • Organizer: 第18回日本耳科学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-16
• [Book] ENTONI(耳閉塞感の診断と治療「耳管開放症の診断と治療」 No.119) (2010)
  • Author(s): 大島猛史
  • Publisher: 全日本病院出版会
• [Book] JOHNS 26 (2010)
  • Author(s): 大島猛史
  • Publisher: 東京医学社