Investigation of pathology of age-related hearing loss and noise-induced hearing loss and application for treatment using gene modification animals
Project/Area Number |
20591979
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Nagoya University |
Principal Investigator |
TERANISHI Masaaki Nagoya University, 医学系研究科, 講師 (20335037)
|
Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Tsutomu 名古屋大学, 大学院・医学系研究科, 教授 (30180277)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 蝸牛 / 加齢 / シグナル伝達 / 培養 / 難聴 / C57BL / 6 |
Research Abstract |
The C57BL/6 mouse is used as animal models of the sensorineural deafness by the aging widely. We show the expression of oxidative stress marker reinforcement of the nucleic acid with aging, and oxidative stress is considered to increase. Proteomics analysis revealed the decrease of mitochondria-related proteins and antioxidant enzymes. Using organ culture of the inner ear, we established a method to evaluate signal transduction after the growth factors administration by immunohistochemistry.
|
Report
(4 results)
Research Products
(85 results)
-
-
[Journal Article] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.2011
Author(s)
Furuta T, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sugiura M, Sone M, Hiramatsu M, Sugiura S, Ando F, Shimokata H, Nakashima T
-
Journal Title
Int J Immunogenet in press
Related Report
Peer Reviewed
-
-
[Journal Article] Association of Interleukin-1 Gene polyxnorphisms with Sudden Sensorineural Hearing Loss and Meniere's disease.2011
Author(s)
Furuta T, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sugiura M, Sone M, Hiramatsu M, Sugiura S, Ando F, Shimokata H, Nakashima T
-
Journal Title
International Journal of Immunogenetics
Volume: 未定(In press)
Related Report
Peer Reviewed
-
-
-
[Journal Article] Relationship between the Degree of Endolymphatic Hydrops and Electrocochleography.2010
Author(s)
Yamamoto M, Teranishi M, Naganawa S, Otake H, Sugiura M, Iwata T, Yoshida T, Katayama N, Nakata S, Sone M, Nakashima T
-
Journal Title
Audiol Neurootol 15
Pages: 254-260
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Relationship between the degree of endolymphatic hydrops and electrocochleography.2010
Author(s)
Yamamoto M, Teranishi M, Naganawa S, Otake H, Sugiura M, Iwata T, Yoshida T, Katayama N, Nakata S, Sone M, Nakashima T
-
Journal Title
Audiol Neurootol
Volume: 16
Pages: 254-260
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] 3D computerized model of endolymphatic hydrops from specimens of temporal bone.2009
Author(s)
Teranishi M., Yoshida, T., Katayama, N., Hayashi, H., Otake, H., Nakata, S., Sone, M., Schachern, P.A., Paparella, M.M., Nakashima T.
-
Journal Title
Acta Otolaryngol Suppl 560
Pages: 43-47
Related Report
Peer Reviewed
-
-
[Journal Article] Endolymphatic space imaging in patients with delayed endolymphatic hydrops.2009
Author(s)
Kasai, S., Teranishi M., Katayama, N., Sugiura,M., Nakata, S., Sone, M., Naganawa, S., Nakashima T.
-
Journal Title
Acta Otolaryngol 129
Pages: 1169-1174
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Journal Article] Endolymphatic space imaging in patients with delayed endolymphatic hydrops.2009
Author(s)
Kasai, S., Teranishi, M., Katayama, N., Sugiura, M., Nakata, S., Sone, M., Naganawa, S., Nakashima, T.
-
Journal Title
Acta Otolaryngol (in press)
Related Report
Peer Reviewed
-
-
-
[Journal Article] Grading of endolymphatic hydrops using magnetic resonance imaging.2009
Author(s)
Nakashima, T., Naganawa, S., Pyykko, I., Gibson, W. P. R., Sone, M., Nakata, S., Teranishi, M.
-
Journal Title
Acta Otolaryngol Suppl 560
Pages: 5-8
Related Report
Peer Reviewed
-
[Journal Article] Clinical significance of endolymphatic imaging after intratympanic gadolinium injection.2009
Author(s)
Nakashima, T., Naganawa, S., Katayama, N., Teranishi, M., Nakata, S., Sugiura, M., Sone, M., Kasai, S., Yoshioka, M., Yamamoto, M.
-
Journal Title
Acta Otolaryngol Suppl 560
Pages: 9-14
Related Report
Peer Reviewed
-
[Journal Article] 3D computerized model of endolymphatic hydrops from specimens of temporal bone.2009
Author(s)
Teranishi, M., Yoshida, T., Katayama, N., Hayashi, H., Otake, H., Nakata, S., Sone, M., Schachern, P. A., Paoarella. M. M., Nakashima, T.
-
Journal Title
Acta Otolaryngol Suppl 560
Pages: 43-47
Related Report
Peer Reviewed
-
-
[Journal Article] Vestibular aqueduct in sudden sensorineural hearing loss.2008
Author(s)
Sugiura, M., Naganawa, S., Ishida, I. M., Teranishi, M., Nakata, S., Yoshida, T., Nakashima, T.
-
Journal Title
J Laryngol Otol 122
Pages: 887-892
Related Report
Peer Reviewed
-
-
[Journal Article] Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings and prognosis in sudden sensorineural hearing loss.2008
Author(s)
Yoshida, T., Sugiura, M., Naganawa, S., Teranishi, M., Nakata, S., Nakashima, T.
-
Journal Title
Laryngoscope 118
Pages: 1433-1437
Related Report
Peer Reviewed
-
-
-
[Presentation] 突発性難聴とメニエール病におけるインターロイキン1遺伝子多型の関連2010
Author(s)
古田敏章, 杉浦真, 平松真理子, 寺西正明, 加藤健, 鈴木秀典, 大竹宏直, 吉田忠雄, 鈴木宏和, 曾根三千彦, 中島務, 内田育恵, 杉浦彩子, 安藤富士子, 下方浩史, 西尾直樹, 多賀谷満彦
Organizer
第143回東海地方部会連合講演会
Place of Presentation
岐阜
Year and Date
2010-12-12
Related Report
-
-
-
-
-
[Presentation] 補体因子Hと突発性難聴との関連について.2010
Author(s)
西尾直樹, 寺西正明, 内田育恵, 杉浦彩子, 安藤富士子, 下方浩史, 曾根三千彦, 大竹宏直, 加藤健, 吉田忠雄, 多賀谷満彦, 日比達也, 中島務
Organizer
第20回日本耳科学会総会・学術講演会
Place of Presentation
松山
Year and Date
2010-10-09
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 3D-computer model of endolymphatic and perilymphatic spaces.2009
Author(s)
Nakata, S., Teranishi, M., Katayama, N., Yoshida, T., Hayashi, H., Otake, H., Sone, M., Nakashima, T.
Organizer
Annual Mid Winter Research Meeting of the Association for Research in Otolaryngology
Place of Presentation
Baltimore, Maryland, USA
Related Report
-
-
-
[Presentation] 3D-Computer model of endolymphatic hydrops.2008
Author(s)
Teranishi M., Yoshida T., Katayama N., Hayashi, H., Otake H., Nakata, S., Sone M., Nakashima T.
Organizer
45th Inner Ear Biology Workshop
Place of Presentation
Ferrara, Italy
Related Report
-
[Presentation] 3D-Computer model of endolymphatic hydrops.2008
Author(s)
Teranishi, M., Yoshida, T., Katayama, N., Hayashi, H., Otake, H., Nakata, S., Sone, M., Nakashima, T.
Organizer
45^<th> Inner Ear Biology Workshop
Place of Presentation
Ferrara, Italy
Related Report
-
[Presentation] Endolymphatic imaging in patients with inner ear diseases.2008
Author(s)
Nakashima, T., Naganawa, S., Teranishi, M., Sone, M., Nakata, S., Sugiura, M., Katayama, N., Yoshida, T., Kasai, S., Yoshioka, M., Yamamoto, M.
Organizer
45^<th> Inner Ear Biology Workshop
Place of Presentation
Ferrara, Italy
Related Report
-
-
[Presentation] 3D-computer model of endolymphatic hydrops from temporal bone specimens.2008
Author(s)
Teranishi, M., Hayashi, H., Sone, M., Nakata, S., Katayama, N., Nakashima, T.
Organizer
2008 Nagoya Symposium on Endolymphatic and Perilymphatic Imaging for Management of Inner Ear Diseases
Place of Presentation
Nagoya
Related Report
-
-
-
-
-
-
-
-