| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Research Abstract |
The C57BL/6 mouse is used as animal models of the sensorineural deafness by the aging widely. We show the expression of oxidative stress marker reinforcement of the nucleic acid with aging, and oxidative stress is considered to increase. Proteomics analysis revealed the decrease of mitochondria-related proteins and antioxidant enzymes. Using organ culture of the inner ear, we established a method to evaluate signal transduction after the growth factors administration by immunohistochemistry.
|
