| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Research Abstract |
I evaluated patterns of p-CREB induction in guinea pig vestibular ganglion cells after various kinds of vestibular disorders. In each model, p-CREB had disappeared within 8 hours after disorder. On the basis of this fact, I found that direct inner ear infusion of rolipram, one of antidepressants, induced p-CREB up-regulation in vestibular ganglion cells. While, rolipram also induced some damage on vestibular ganglion cells morphologically. Next, amitriptyline, a tricyclic antidepressant, was applied systemically to guinea pig with vestibular disorder, and facilitated vestibular functional recovery.
|
