Vestibular plasticity-a role of vestibular ganglion-
| Project/Area Number |
20591984
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
SHIMOGORI Hiroaki Yamaguchi University, 大学院・医学系研究科, 准教授 (70226273)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | 前庭神経系 / 前庭神経節 / CREB / 抗うつ薬 / VOR / BDNF / ロリプラム / roripram |
|---|
| Research Abstract |
I evaluated patterns of p-CREB induction in guinea pig vestibular ganglion cells after various kinds of vestibular disorders. In each model, p-CREB had disappeared within 8 hours after disorder. On the basis of this fact, I found that direct inner ear infusion of rolipram, one of antidepressants, induced p-CREB up-regulation in vestibular ganglion cells. While, rolipram also induced some damage on vestibular ganglion cells morphologically. Next, amitriptyline, a tricyclic antidepressant, was applied systemically to guinea pig with vestibular disorder, and facilitated vestibular functional recovery.
|
Report
(4 results)
Research Products
(22 results)
-
-
[Presentation] 抗うつ剤と前庭神経系の可塑性2010
Author(s)
下郡博明, 豊田英樹, 菅原一真, 橋本誠, 山下裕司
Organizer
第69回日本めまい平衡医学会総会・学術講演会
Place of Presentation
京都 国立京都国際会館
Year and Date
2010-11-18
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
