A fundamental study for the degeneration site of Bell's palsy

• Project/Area Number: 20591986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Ehime University
• Principal Investigator: WAKISAKA Hiroyuki Ehime University, 大学院・医学系研究科, 准教授 (30304611)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ベル麻痺 / HSV-1 / 電子顕微鏡 / HDV-1 / ルートエントリーゾーン / 中枢感染 / 顔面神経核

Research Abstract

HSV-1 infected to the geniculate ganglion, the root entry zone, facial nucleus in the HSV-1 primary infected mouse facial palsy model. Therefore, these three sites are thought as HSV-1 latency sites. Moreover, HSV replicated in the neuron of the the geniculate ganglion and facial nucleus in the HSV-1 reactivated mouse facial palsy model. These facts suggested that the nerve degenelation at these two sites may occur the facial palsy with HSV-1 reactivation.

Research Products

• [Journal Article] Clinical features and outcomes of four patients with invasive fungal sinusitis. (2011)
  • Author(s): Takahashi H, Hinohira Y, Hato N, Wakisaka H, Hyodo J, Ugumori T, Gyo K.
  • Journal Title: Auris Nasus Larynx. 38(2) Pages: 289-294
  • Peer Reviewed
• [Journal Article] Incidence of long-term ipsilateral and contralateral ototoxicity following radiotherapy for nasopharyngeal carcinoma. (2011)
  • Author(s): Wakisaka H, Yamada H, Motoyoshi K, Ugumori T, Takahashi H, Hyodo M.
  • Journal Title: Auris Nasus Larynx. Volume: 38 Pages: 95-100
  • Peer Reviewed
• [Journal Article] A case of a wooden foreign bodypenetrating the oral cavity and reaching the posterior neck (2010)
  • Author(s): Wakisaka H, Takahashi H, Ugumori T, Motoyoshi K, Takagi D
  • Journal Title: Injury Extra. [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Incidence of long-term ipsilateral and contralateral ototoxicity following radiotherapy for nasopharyngeal carcinoma. (2010)
  • Author(s): Wakisaka H, Yamada H, Motoyoshi K, Ugumori T, Takahashi H, Hyodo M.
  • Journal Title: Auris Nasus Larynx. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Facial synkinesis after experimental compression of the facial nerve comparing intratemporal and extratemporal lesions. (2010)
  • Author(s): Yamada H, Hato N, Murakami S, Honda N, Wakisaka H, Takahashi H, Gyo K.
  • Journal Title: Laryngoscope. 120(5) Pages: 1022-1027
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor combined with biodegradable hydrogel promotes healing of facial nerve after compression injury : an experimental study. (2010)
  • Author(s): Komobuchi H, Hato N, Teraoka M, Wakisaka H, Takahashi H, Tabata Y, Yamamoto M.
  • Journal Title: Acta Otolaryngol. 130(1) Pages: 173-178
  • Peer Reviewed
• [Journal Article] 顔面像センシング技術OKAO VISIONを用いた顔面神経麻痺の新しい客観的評価法の開発 (2010)
  • Author(s): 澤井尚樹, 羽藤直人, 寺岡正人, 高橋宏尚, 脇坂浩之, 飴矢美里, 暁清文
  • Journal Title: Facial Nerve Research 29巻 Pages: 68-70
  • Peer Reviewed
• [Journal Article] Facial synkinesis after experimental compression of the facial nerve comparing intratemporal and extratemporal lesions. (2010)
  • Author(s): Yamada H, Hato N, Murakami S, Honda N, Wakisaka H, Takahashi H, Gyo K.
  • Journal Title: Laryngoscope Volume: 120(5) Pages: 1022-7
  • Peer Reviewed
• [Journal Article] A case of a wooden foreign bodypenetrating the oral cavity and reaching the posterior neck (2010)
  • Author(s): Wakisaka H, Takahashi H, Ugumori T, Motoyoshi K, Takagi D
  • Journal Title: Injury Extra. Volume: June 23.(epub)
  • Peer Reviewed
• [Journal Article] The effects of a novel local ventilation system to reduce the health hazard to students during gross anatomy courses (2009)
  • Author(s): Matsuda S, Hasegawa M, Muro H, Asano H, Hamada F, Shimokawa T, Miyawaki K, Nabeka H, Wakisaka H, Hamai M, Kobayashi N.
  • Journal Title: Kaibogaku Zasshi. 84(4) Pages: 103-109
  • NAID: 10026095003
  • Peer Reviewed
• [Journal Article] 当科における両側性および反復性顔面神経麻痺症例の検討 (2009)
  • Author(s): 澤井尚樹, 羽藤直人, 寺岡正人, 脇坂浩之, 高橋宏尚, 暁清文
  • Journal Title: Facial Nerve Research 28巻 Pages: 54-57
  • NAID: 10026102798
  • Peer Reviewed
• [Journal Article] HSV-1再活性化時の神経軸索および終末におけるHSV-1の輸送と成熟 (2009)
  • Author(s): 脇坂浩之
  • Journal Title: JHIF 15 Pages: 120-124
  • Peer Reviewed
• [Journal Article] Valacyclovir for the treatment of Bell's palsy. (2008)
  • Author(s): Hato N, Sawai N, Teraoka M, Wakisaka H, Takahashi H, Hinohira Y, Gyo K.
  • Journal Title: Expert Opin Pharmacother. 9(14) Pages: 2531-2536
  • Peer Reviewed
• [Presentation] HSV-1再活性化時の神経軸索および終末におけるHSV-1の輸送と成熟 (2009)
  • Author(s): 脇坂浩之
  • Organizer: 日本解剖学会中国四国連合会学術講演会
  • Place of Presentation: 高知県
  • Year and Date: 2009-11-29
• [Presentation] Distribution of herpes simplex virus type 1 in mouse model of bell's palsy (2009)
  • Author(s): Matsumoto S, Hato N, Kohno H, Yamada Y, Kisaki H, Wakisaka H, Takahashi H, Honda N, Gyo K
  • Organizer: XI International Facial Nerve Symposium Roma Italy
• [Presentation] The real time objective and quick evaluation of facial paralysis (2009)
  • Author(s): Sawai N, Hato N, Teraoka M, Takahashi H, Wakisaka H, Gyo K
  • Organizer: XI International Facial Nerve Symposium Roma Italy
• [Presentation] 神経終末におけるHSV-1増殖成熟メカニズムに関する研究 (2008)
  • Author(s): 脇坂浩之
  • Organizer: 日本ヘルペスウイルス感染症フォーラム
  • Place of Presentation: 札幌
  • Year and Date: 2008-08-16