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The role of water channel of aquaporins and water pump of Na-K-2Cl co-transporter on the water homeostasis of the inner ear.

Research Project

Project/Area Number 20591987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKochi University

Principal Investigator

TAKEDA Taizo (2008, 2010)  Kochi University, 名誉教授 (50115763)

竹田 泰三 (2009)  Kochi University, 名誉教授 (50115705)

Co-Investigator(Kenkyū-buntansha) NISHIOKA Rie  高知大学, 教育研究部・医療学系, 助教 (20398051)
KAKIGI Akinobu  東京大学, 医学部, 講師 (60243820)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsaquaporin / イオン共輸送体 / 血管条 / 内リンパ嚢 / vasopressin / 水チャネル / NKCC1 / NKCC2 / stria vascularis / endolymphatic sac / bumetanide / 内耳水代謝
Research Abstract

The expressions of many subtypes of aquaporins (AQP) including AQP-2, vasopressin type 2 receptor, and NKCC1 were molecular biologically and immunohistochemically evaluated. Since the application of vasopressin, bumetanide, and OPC-31260 exerted the morphological influence on the intrastrial space, AQP2-vasopressin mediated water transport and water flow through the Na-K-Cl co-transporter might work actively in the inner ear fluid homeostasis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Hormonal Aspects of Meniere's Disease on the Basis of Clinical and Experimental Studies.2010

    • Author(s)
      Taizo Takeda, Setsuko Takeda, Akinobu Kakigi, Rie Nishioka, Daizo Taguchi, Masahiko Nishimura, Hiroaki Nakatani.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec 71(Suppl 1)

      Pages: 1-9

    • Related Report
      2010 Final Research Report
  • [Journal Article]2010

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Okada T, Doi K.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 71(Suppl 1)

      Pages: 10-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of Aquaporins and Vasopressin type 2 receptor in the stria vascularis of the cochlea.2010

    • Author(s)
      Nishioka R, Takeda T, Kakigi A, Okada T, Takebayashi S, Nishimura M, Taguchi D, Hyodo M.
    • Journal Title

      Hear Res. 260

      Pages: 11-19

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hormonal Aspects of Meniere's Disease on the Basis of Clinical and Experimental Studies2010

    • Author(s)
      Taizo Takeda, Setsuko Takeda, Akinobu Kakigi, Rie Nishioka, Daizo Taguchi, Masahiko Nishimura, Hiroaki Nakatani
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 71 Suppl 1 Pages: 1-9

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Bumetanide-Induced Enlargement of the Rat Intrastrial Space and Effects of a Vasopressin Type 2 Antagonist2010

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Okada T, Doi K
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 71 Suppl 1 Pages: 10-15

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Expression of Aquaporins and Vasopressin type 2 receptor in the stria vascularis of the cochlea2010

    • Author(s)
      Nishioka R, Takeda T, Kakigi A, Okada T, Takebayashi S, Nishimura M, Taguchi D, Hyodo M
    • Journal Title

      Hear Res

      Volume: 260 Pages: 11-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Aquaporin1, 3, and 4, NKCC1, and NKCC2 in the Human Endolymphatic Sac.2009

    • Author(s)
      Kakigi A, Nishimura M, Takeda T, Taguchi D, Nishimura R.
    • Journal Title

      Auris Nasus Larynx. 36

      Pages: 135-139

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist.2009

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Okada T, Doi K.
    • Journal Title

      Acta Otolaryngol 129

      Pages: 709-715

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Aquaporin1, 3, and 4, NKCC1, and NKCC2 in the Human Endolymphatic Sac2009

    • Author(s)
      Kakigi A, Nishimura M, Takeda T, Taguchi D, Nishimura R
    • Journal Title

      Auris Nasus Larynx 36

      Pages: 135-139

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time course changes of vasopressin-induced enlargement of the rat intrastrial space amd the effects of a vasopressin type 2 antagonist2009

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Okada T, Doi K
    • Journal Title

      Acta Otolaryngol 129

      Pages: 709-715

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and immunelocalization of Aquaporin-6 (Aqp6) in the rat inner ear.2008

    • Author(s)
      Taguchi D, Takeda T, Kakigi A, Okada T, Nishioka R, Kitano H.
    • Journal Title

      Acta Otolaryngol 128

      Pages: 832-840

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and immunolocalization of Aquaporin-6 (Aqp6) in the rat inner ear2008

    • Author(s)
      Taguchi D, Takeda T, Kakigi A, Okada T, Nishioka R, Kitano H
    • Journal Title

      Acta Otolaryngol 128

      Pages: 832-840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of aquaporins, vasopressin type 2receptor and Na+-K+-Cl- cotransporters in the rat endolymphatic sac

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Takeda S, Doi K
    • Journal Title

      Acta Otolaryngol (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Aquaporins as Potentials Drug Targets for Meniere's Disease and Its Related Diseases2010

    • Author(s)
      Takeda T, Kakigi A
    • Organizer
      6th International Symposium on Meniere's disease and Inner Ear Disorders
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression of aquaporin1, 2, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac.2008

    • Author(s)
      Kakigi A, Nishimura M, Takeda T, Taguchi D, Nishioka R.
    • Organizer
      45^<th> Inner Ear Biology Workshop
    • Place of Presentation
      Ferrara, Italy.
    • Year and Date
      2008-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of aquaporin1, 2, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac2008

    • Author(s)
      Kakigi A, Nishimura M, Takeda T, Taguchi D, Nishioka R
    • Organizer
      45^<th> Inner Ear Biology Workshop
    • Place of Presentation
      Ferrara, Italy
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression of aquaporins, vasopressin type 2 receptor, and Na+-K+-Cl cotransporters in the rat endolymphatic sac.2008

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Takeda S, Nishioka R, Doi K.
    • Organizer
      45th Inner Ear Biology Workshop.
    • Place of Presentation
      Ferrara, Italy.
    • Year and Date
      2008-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of aquaporins, vasopressin type 2 receptor, and Na+-K+-Cl cotransporters in the rat endolymphatic sac2008

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Takeda S, Nishioka R, Doi K
    • Organizer
      45th Inner Ear Biology Workshop.
    • Place of Presentation
      Ferrara, Italy
    • Year and Date
      2008-09-22
    • Related Report
      2008 Annual Research Report
  • [Book] Handbook of Experimental Pharmacology 190, Aquaporins (ed. by Beit E). Aquaporins as potential drug targets for Meniere's disease and its related diseases2009

    • Author(s)
      Takeda T, et al.
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Handbook of Experimental Pharmacology 190, Aquaporins (ed. by Beit E). Aquaporins as potential drug targets for Meniere's disease and its related diseases2009

    • Author(s)
      Takeda T, Taguchi D
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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