| Project/Area Number |
20591992
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
FURUKAWA Masayuki Juntendo University, 医学部, 准教授 (20359524)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IKEDA Katuhisa 順天堂大学, 医学部, 教授 (70159614)
KUSUNOKI Takeshi 順天堂大学, 医学部, 准教授 (30248025)
YOKOI Hidenori 順天堂大学, 医学部, 准教授 (80317487)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | DNA microarray / 中耳粘膜肥厚 / 中耳炎 / Haemophilus influenzae / 中耳粘膜 / Haemophilus influenza / DNA array / 中耳炎モデル動物 |
|---|
| Research Abstract |
We used gene array to assess gene expression in the mouse middle ear in the first 24h following exposure to Haemophilus influenzae. We observed 513 transcripts that were significantly up-regulated 3h after inoculation, while only 2 transcripts were down-regulated. At 6h, 658 up-regulated transcripts were noted, as compared to 188 down-regulated genes. By 24h after bacterial exposure, 1350 transcripts showed increased expression while 1632 exhibited reduced expression.
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