Treatment strategy for intractable otitis media to elucidate an etiology of eosinophilic otitis media

• Project/Area Number: 20591995
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Fukuoka University
• Principal Investigator: NAKAGAWA Takashi Fukuoka University, 医学部, 教授 (70274470)
• Co-Investigator(Renkei-kenkyūsha): HIROMATSU Kenji 福岡大学, 医学部, 教授 (80252237)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 耳科学 / 免疫学 / 好酸球性中耳炎 / サイトカイン / 診断基準 / Th2関連炎症 / 自然免疫系 / IL5 / IL13 / Th2細胞性炎症 / Th1細胞性炎症 / 自然免疫 / IL-5 / IL-13

Research Abstract

Etiology of eosinophilic otitis media (EOM) was elucidated. Th2-related inflammation is dominant in middle ear cavity of EOM patient. When otorrhea increases, Thl-related reaction accompanies. Innate immune reaction is activated more than that of chronic otitis media. Diagnostic criteria was determined by a cooperation with other facilities.

Research Products

• [Journal Article] Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease. (2011)
  • Author(s): Iino Y, Tomioka-Matsutani S, Matsubara A, Nakagawa T, Nonaka M
  • Journal Title: Auris Nasus Larynx 38巻 Pages: 456-461
  • Peer Reviewed
• [Journal Article] Diagnostic criteria of eosinophilic otitis media, a newly recognizedmiddle ear disease (2011)
  • Author(s): Iino, Tomioka-Matsutani, Matsubara, Nakagawa, Nonaka
  • Journal Title: Auris Nasus Larynx Volume: 印刷中
  • Peer Reviewed
• [Presentation] 気管支喘息の有無における好酸球性中耳炎臨床像の比較検討 (2010)
  • Author(s): 松原篤、飯野ゆき子、松谷幸子、中川尚志、野中学、新川秀一
  • Organizer: 第20回日本耳科学会総会学術講演会
  • Place of Presentation: 松山
  • Year and Date: 2010-10-07
• [Presentation] 好酸球性中耳炎診断基準2009の検証 (2010)
  • Author(s): 飯野ゆき子、松谷幸子、松原篤、中川尚志、野中学
  • Organizer: 第28回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 福井
  • Year and Date: 2010-02-18
• [Presentation] 好酸球性中耳炎における聴力障害 (2009)
  • Author(s): 中川尚志
  • Organizer: 第54回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] 好酸球性中耳炎における聴力障害 (2009)
  • Author(s): 中川尚志
  • Organizer: 第54回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 横浜, 新横浜プリンスホテル
  • Year and Date: 2009-10-23
• [Book] 症例から見る難治性疾患の診断と治療-耳科領域編- (2011)
  • Author(s): 中川尚志、小宗静男
  • Publisher: 国際医学出版
• [Book] EBM耳鼻咽喉科・頭頸部外科の治療2010-2011 (2010)
  • Author(s): 中川尚志
  • Publisher: 中外医学社
• [Book] 今日の耳鼻咽喉科・頭頸部外科治療指針 第3版 (2008)
  • Author(s): 中川尚志
  • Total Pages: 163
  • Publisher: 医学書院
• [Book] 好酸球性中耳炎. 今日の耳鼻咽喉科・頭頚部外科治療指針. 第3版 (2008)
  • Author(s): 中川尚志
  • Total Pages: 1
  • Publisher: 医学書院