Influence on allergic rhinitis of the endocrine disruptor
| Project/Area Number |
20591998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
YAMAMOTO Hideyuki University of Fukui, 医学部附属病院, 助教 (50345691)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIEDA Shigeharu 福井大学, 医学部, 教授 (30238539)
YAMADA Takechiyo 福井大学, 医学部附属病院, 講師 (70283182)
YAMAMOTO Takehito 福井大学, 医学部附属病院, 講師 (80303379)
KIMURA Yuichi 福井大学, 医学部, 助教 (50281035)
OKAMOTO Masayuki 福井大学, 医学部附属病院, 医員 (90464057)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 鼻科学 / アレルギー性鼻炎 / 内分泌撹乱物質 / PD-ECGF / IgE / STAT6 / TPI / 血管新生 / SNP / DEPs / CYP1A1 / genotyping / 酸化ストレス / スギ花粉症 / 末梢血単核球 / ビスフェノールA / ノニルフェノール / スチレンモノマー / 低用量効果 |
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| Research Abstract |
I examined it with IgE production culture system of human peripheral blood mononuclear cells (PBMC) about the influence on allergic rhinitis of the endocrine disruptor. It became clear, although there is the difference by a material ,that the endocrine disruptor was proved IgE production enhancement as a low-dose effect. In addition, I understood that there was individual difference in the reaction. I accepted a meaningful correlation of SNP and adult cedar pollinosis onset of gene CYP1A1 about environmental chemical substance metabolism. Platelet-derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase (TP) is a potent angiogenic factor. Our results suggest TP involvement in the enhancement of IgE production and suggest that Thymidine phosphorylase inhibitor (TPI) might be a novel strategy against IgE-related allergic disease.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Efficacy of oral olopatadine hydrochloride for the treatment of seasonal allergic rhinitis2010
Author(s)
Hideyuki Yamamoto, Takechiyo Yamada, Seita Kubo, Yoko Osawa, Yuichi Kimura, Myonmi Oh, Dai Susuki, Tetsuji Takabayashi, Masayuki Okamoto, Shigeharu Fujieda.
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Journal Title
A randomized, double-blind, placebo-controlled study. 31(4)
Pages: 296-303
Related Report
Peer Reviewed
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[Presentation] Clinical efficacy and QOL assessment of olopatadine hydrochloride in the Japanese cedar pollinosis (JCP) Treatment.2009
Author(s)
Hideyuki Yamamoto, Shigeharu Fujieda, Takechiyo Yamada, Takehito Yamamoto, Yuchi Kimura, Hiroshi Sunaga, Yoko Osawa, Masayuki Okamoto, Seita Kubo, Myongmi Oh, Dai Susuki, Kazuhiro Ogi, Akihiro Kojima.
Organizer
XIX WORLD CONGRESS OF OTO-RHINO-LARYNGOLOGY
Place of Presentation
Sao Paulo
Year and Date
2009-06-03
Related Report
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